NAPA (gene)
Encyclopedia
N-ethylmaleimide-sensitive factor attachment protein, alpha, also known as NAPA or alpha-SNAP, is a human gene
.
It is abnormally expressed in fetuses of both IVF and ICSI
, which may contribute to the increase risk of birth defects in these ART
.
with STX4
, SNAP23
, STX1A
, N-ethylmaleimide sensitive fusion protein
and STX5
.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
It is abnormally expressed in fetuses of both IVF and ICSI
Intracytoplasmic sperm injection
Intracytoplasmic sperm injection is an in vitro fertilization procedure in which a single sperm is injected directly into an egg.-Indications:...
, which may contribute to the increase risk of birth defects in these ART
Assisted reproductive technology
Assisted reproductive technology is a general term referring to methods used to achieve pregnancy by artificial or partially artificial means. It is reproductive technology used primarily in infertility treatments. Some forms of ART are also used in fertile couples for genetic reasons...
.
Interactions
NAPA (gene) has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with STX4
STX4
Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.-Interactions:STX4 has been shown to interact with SNAP-25, NAPA, STXBP5, SNAP23, Vesicle-associated membrane protein 8, RAB4A, TXLNB, VAMP2, VAMP3, STXBP1 and Syntaxin binding protein 3.-Further reading:...
, SNAP23
SNAP23
Synaptosomal-associated protein 23 is a protein that in humans is encoded by the SNAP23 gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.- Function :...
, STX1A
STX1A
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.- Function :Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to...
, N-ethylmaleimide sensitive fusion protein
N-ethylmaleimide sensitive fusion protein
N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene.- Function :...
and STX5
STX5
Syntaxin-5 is a protein that in humans is encoded by the STX5 gene.-Interactions:STX5 has been shown to interact with NAPA, GOSR1, GOSR2, BET1L and USO1.-Further reading:...
.