NCK1
Encyclopedia
Cytoplasmic protein NCK1 is a protein
that in humans is encoded by the NCK1 gene
.
with DNM1
, EIF2B2
, KHDRBS1
, Lymphocyte cytosolic protein 2
, EPH receptor B1
, SOCS7
, MINK1
, MAP4K1
, MAP4K4
, Abl gene
, WIPF1
, RRAS
, Wiskott-Aldrich syndrome protein
, Epidermal growth factor receptor
, PDGFRB
, PTK2
, NCKIPSD
, RICS
, Cbl gene
, TANK-binding kinase 1
, SOS1
, Dystroglycan
, PAK1
, PKN2
, NEDD9
, WASL
and RASA1.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the NCK1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
NCK1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with DNM1
DNM1
Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.-Interactions:DNM1 has been shown to interact with Amphiphysin, FNBP1, NCK1, PACSIN1, Grb2 and SH3GL2.-Further reading:...
, EIF2B2
EIF2B2
Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.-Interactions:EIF2B2 has been shown to interact with EIF2B5 and NCK1.-Further reading:...
, KHDRBS1
KHDRBS1
KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene.-Further reading:...
, Lymphocyte cytosolic protein 2
Lymphocyte cytosolic protein 2
Lymphocyte cytosolic protein 2 , also known as LCP2 or SLP-76, is a gene that encodes a signal-transducing adaptor protein.-Interactions:...
, EPH receptor B1
EPH receptor B1
Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.-Interactions:EPH receptor B1 has been shown to interact with GRB7, ACP1 and NCK1.-Further reading:...
, SOCS7
SOCS7
Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.-Further reading:...
, MINK1
MINK1
Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.- Function :Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct...
, MAP4K1
MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.. It is also known as HPK1 .-Interactions:...
, MAP4K4
MAP4K4
Mitogen-activated protein kinase kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP4K4 gene.-Interactions:MAP4K4 has been shown to interact with NCK1 and CD29.-Further reading:...
, Abl gene
Abl gene
V-abl Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9.- Function :...
, WIPF1
WIPF1
WAS/WASL-interacting protein family member 1 is a protein that in humans is encoded by the WIPF1 gene.-Interactions:WIPF1 has been shown to interact with Wiskott-Aldrich syndrome protein, Cortactin and NCK1.-Further reading:...
, RRAS
RRAS
Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene.-Interactions:RRAS has been shown to interact with RASSF5, NCK1, Bcl-2, ARAF and RALGDS.-Further reading:...
, Wiskott-Aldrich syndrome protein
Wiskott-Aldrich syndrome protein
The Wiskott–Aldrich Syndrome Protein is a 502-amino acid protein that is expressed in cells of the hematopoietic system. In the inactive state, WASp exists in an auto-inhibited conformation with sequences near its C-terminus binding to a region near its N-terminus...
, Epidermal growth factor receptor
Epidermal growth factor receptor
The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands...
, PDGFRB
PDGFRB
Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.-Interactions:PDGFRB has been shown to interact with PTPN11, NCK1, Grb2, Caveolin 1, PDGFRA, Sodium-hydrogen antiporter 3 regulator 1, RAS p21 protein activator 1, CRK, SHC1 and...
, PTK2
PTK2
PTK2 protein tyrosine kinase 2 , also known as Focal Adhesion Kinase , is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes...
, NCKIPSD
NCKIPSD
NCK-interacting protein with SH3 domain is a protein that in humans is encoded by the NCKIPSD gene.-Interactions:NCKIPSD has been shown to interact with Grb2 and NCK1.-Further reading:...
, RICS
RICS (gene)
Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene. RICS has two known isoforms, RICS that are expressed primarily at neurite growth cones, and at the post synaptic membranes, and PX-RICS which is more widely expressed in the endoplasmic reticulum, Golgi...
, Cbl gene
Cbl gene
Cbl is a mammalian gene encoding several proteins including E3 ubiquitin-protein ligase CBL involved in cell signalling and protein ubiquitination...
, TANK-binding kinase 1
TANK-binding kinase 1
Serine/threonine-protein kinase TBK1 is an enzyme that in humans is encoded by the TBK1 gene.-Interactions:TANK-binding kinase 1 has been shown to interact with NCK1, TRAF2 and TANK.-Further reading:...
, SOS1
SOS1
Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.Recent studies also show that mutations in Sos1 can cause Noonan syndrome and hereditary gingival fibromatosis type 1. Noonan syndrome has also been shown to be caused by mutations in KRAS and PTPN11 genes...
, Dystroglycan
Dystroglycan
Dystroglycan is a protein that in humans is encoded by the DAG1 gene.Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in Homo sapiens by chromosome 3. There are two exons that are separated by a large intron...
, PAK1
PAK1
Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene.-Interactions:PAK1 has been shown to interact with C-Raf, NCK1, LIMK1, RAC1, ARHGEF2, BMX, ARPC1B, DYNLL1, Cyclin-dependent kinase 5, PAK1IP1 and CDC42....
, PKN2
PKN2
Serine/threonine-protein kinase N2 is an enzyme that in humans is encoded by the PKN2 gene.-Interactions:PKN2 has been shown to interact with Phosphoinositide-dependent kinase-1, AKT1, NCK1, PTPN13 and RHOA.-Further reading:...
, NEDD9
NEDD9
Enhancer of filamentation 1 is a protein that in humans is encoded by the NEDD9 gene.-Interactions:NEDD9 has been shown to interact with ID2, LYN, NCK1, MICAL1, CDH1, Abl gene, PTK2, CRKL, CRK and Mothers against decapentaplegic homolog 3....
, WASL
WASL (gene)
Neural Wiskott-Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene.The Wiskott-Aldrich syndrome family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton...
and RASA1.
External links
- Nck1 Info with links in the Cell Migration Gateway