MAP4K1
Encyclopedia
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase
that in humans is encoded by the MAP4K1 gene
.. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).
with B-cell linker
, Grb2
, CRKL
, Drebrin-like
, CRK
, Linker of activated T cells
, NCK1
and GRAP2
.
Protein kinase
A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them . Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins...
that in humans is encoded by the MAP4K1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1).
Interactions
MAP4K1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with B-cell linker
B-cell linker
The B-cell linker protein is encoded by the BLNK gene and is an adaptor protein also known as SLP-65, BASH, and BCA. BLNK is expressed in B cells and macrophages and plays a large role in B cell receptor signalling, in a fashion analogous to the role its paralogue SLP-76 plays in T cell receptor...
, Grb2
Grb2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene....
, CRKL
CRKL
Crk-like protein is a protein that in humans is encoded by the CRKL gene.CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.-Interactions:...
, Drebrin-like
Drebrin-like
Drebrin-like protein is a protein that in humans is encoded by the DBNL gene.-Interactions:Drebrin-like has been shown to interact with Cyclin-dependent kinase 4, MAP4K1 and ZAP-70.-Further reading:...
, CRK
CRK (gene)
Adapter molecule crk also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene.- Function :...
, Linker of activated T cells
Linker of activated T cells
Linker of Activated T cells, also known as LAT, is a protein which in humans is encoded by the LAT gene. Alternative splicing results in multiple transcript variants encoding different isoforms.-Function:...
, NCK1
NCK1
Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.-Interactions:NCK1 has been shown to interact with DNM1, EIF2B2, KHDRBS1, Lymphocyte cytosolic protein 2, EPH receptor B1, SOCS7, MINK1, MAP4K1, MAP4K4, Abl gene, WIPF1, RRAS, Wiskott-Aldrich syndrome protein,...
and GRAP2
GRAP2
GRB2-related adapter protein 2 is a protein that in humans is encoded by the GRAP2 gene.-Interactions:GRAP2 has been shown to interact with CD28, STAMBP, CCNDBP1, Linker of activated T cells, Lymphocyte cytosolic protein 2 and MAP4K1....
.