CRKL - AbsoluteAstronomy.com

Crk-like protein is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

that in humans is encoded by the CRKL gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.
CrkL together with Crk

CRK (gene)

Adapter molecule crk also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene.- Function :...

participates in the Reelin

Reelin

Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...

signaling cascade downstream of DAB1

DAB1

The Disabled-1 gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathway...

Interactions

CRKL has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

with GAB2

GAB2

GRB2-associated-binding protein 2 is a protein that in humans is encoded by the GAB2 gene.The protein encoded by this gene, GAB2 is an adaptor protein serving as principal activator of Phosphatidylinositol 3-kinase...

, CD34

CD34

CD34 molecule is a cluster of differentiation molecule present on certain cells within the human body. It is a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells...

, CD117

CD117

Mast/stem cell growth factor receptor also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117 is a protein that in humans is encoded by the KIT gene...

, MAP4K5

MAP4K5

Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.-Interactions:MAP4K5 has been shown to interact with CRKL and TRAF2.-Further reading:...

, MAP4K1

MAP4K1

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.. It is also known as HPK1 .-Interactions:...

, Syk

Syk

Spleen tyrosine kinase, also known as Syk, is an enyzme which in humans is encoded by the SYK gene.- Function :SYK, along with Zap-70, is a member of the Syk family of tyrosine kinases...

, RAPGEF1

RAPGEF1

Rap guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the RAPGEF1 gene.-Interactions:RAPGEF1 has been shown to interact with BCAR1, Grb2, HCK, CRKL and CRK.-External links:* Info with links in the...

, Abl gene

Abl gene

V-abl Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene located on chromosome 9.- Function :...

, BCAR1

BCAR1

Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.-External links:* Info with links in the...

, STAT5A

STAT5A

Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. STAT5A orthologs have been identified in several placentals for which complete genome data are available.-Interactions:...

, Wiskott-Aldrich syndrome protein

Wiskott-Aldrich syndrome protein

The Wiskott–Aldrich Syndrome Protein is a 502-amino acid protein that is expressed in cells of the hematopoietic system. In the inactive state, WASp exists in an auto-inhibited conformation with sequences near its C-terminus binding to a region near its N-terminus...

, RICS

RICS (gene)

Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene. RICS has two known isoforms, RICS that are expressed primarily at neurite growth cones, and at the post synaptic membranes, and PX-RICS which is more widely expressed in the endoplasmic reticulum, Golgi...

, CBLB

CBLB

E3 ubiquitin-protein ligase CBL-B is an enzyme that in humans is encoded by the CBLB gene.-Interactions:CBLB has been shown to interact with Epidermal growth factor receptor, Grb2, PIK3R1, SH3KBP1, CRKL and NEDD4.-Further reading:...

, Erythropoietin receptor

Erythropoietin receptor

The erythropoietin receptor is a protein that in humans is encoded by the EPOR gene. EpoR is a 59 kDa peptide and is a member of the cytokine receptor family. EpoR pre-exists as dimers...

, BCR gene

BCR gene

The BCR gene is one of the two genes in the bcr-abl complex, which is associated with the Philadelphia chromosome.-Pathology:...

, Cbl gene

Cbl gene

Cbl is a mammalian gene encoding several proteins including E3 ubiquitin-protein ligase CBL involved in cell signalling and protein ubiquitination...

, INPP5D

INPP5D

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 is an enzyme that in humans is encoded by the INPP5D gene.-Interactions:INPP5D has been shown to interact with DOK2, LYN, CD22, Grb2, CRKL, CD31, DOK1 and SHC1.-Further reading:...

, Dock2

DOCK2

Dock2 , also known as DOCK2, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins...

, NEDD9

NEDD9

Enhancer of filamentation 1 is a protein that in humans is encoded by the NEDD9 gene.-Interactions:NEDD9 has been shown to interact with ID2, LYN, NCK1, MICAL1, CDH1, Abl gene, PTK2, CRKL, CRK and Mothers against decapentaplegic homolog 3....

, PIK3R2

PIK3R2

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.-Interactions:PIK3R2 has been shown to interact with FYN, HER2/neu, Epidermal growth factor, Cbl gene, PIK3CD, CRKL and Macrophage colony-stimulating factor.-Further reading:...

, Paxillin

Paxillin

Paxillin is a signal transduction adaptor protein discovered in 1990 in the laboratory of Keith Burridge and should not be confused with the neurotoxin paxilline. The C-terminal region of paxillin contains four LIM domains that target paxillin to focal adhesions, it is presumed through a direct...

and GAB1

GAB1

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.-Interactions:GAB1 has been shown to interact with Grb2, PIK3R1, PTPN11, CRKL, PLCG1 and MAP3K3.-Further reading:...