NEUROD1
Encyclopedia
Neurogenic differentiation 1 (NeuroD1), also called β2 is a transcription factor
of the NeuroD
-type. It is encoded by the human gene NEUROD1.
It is a member of the NeuroD family of basic-helix-loop-helix
(bHLH) transcription factor
s. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.
with MAP3K10
, MAFA
and Cyclin D1
.
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
of the NeuroD
NeuroD
NeuroD, also called Beta2, is a basic helix loop helix transcription factor expressed in certain parts of brain, beta pancreatic cells and enteroendocrine cells. It is involved in the differentiation of nervous system and development of pancreas...
-type. It is encoded by the human gene NEUROD1.
It is a member of the NeuroD family of basic-helix-loop-helix
Basic-helix-loop-helix
A basic helix-loop-helix is a protein structural motif that characterizes a family of transcription factors.- Structure :The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino...
(bHLH) transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.
Interactions
NEUROD1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with MAP3K10
MAP3K10
Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.-Interactions:MAP3K10 has been shown to interact with NEUROD1, Huntingtin, MAPK8IP1, KIF3A, CDC42 and MAPK8IP2.-Further reading:...
, MAFA
MAFA (gene)
Transcription factor MafA is a protein that in humans is encoded by the MAFA gene.-Interactions:MAFA has been shown to interact with NEUROD1 and Pdx1.-Further reading:...
and Cyclin D1
Cyclin D1
G1/S-specific cyclin-D1 is a protein that in humans is encoded by the CCND1 gene.Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma.-Interactions:...
.