Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the NOS1AP gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase

NOS1

Nitric oxide synthase 1 , also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.- Function :Nitric oxide is a messenger molecule with diverse functions throughout the body...

 (nNOS). This protein has a C-terminal PDZ

PDZ domain

The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals...

-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1

RASD1

Dexamethasone-induced Ras-related protein 1 is a protein that in humans is encoded by the RASD1 gene.-Further reading:...

. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsin

Synapsin

The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at synapses. Specifically, they are thought to be involved in regulating the number of synaptic vesicles available for release via exocytosis at any one time.Current studies suggest...

s. NOS1AP polymorphisms has been associated with the QT interval

QT interval

In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle. In general, the QT interval represents electrical depolarization and repolarization of the left and right ventricles...

 length.

Interactions

NOS1AP has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with:

• LRP1
  LRP1
  Low density lipoprotein receptor-related protein 1 , also known as alpha-2-macroglobulin receptor , apolipoprotein E receptor or cluster of differentiation 91 , is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis...
  
  ,
• LRP2
  LRP2
  Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.-Function:...
  
  ,
• NOS1
  NOS1
  Nitric oxide synthase 1 , also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.- Function :Nitric oxide is a messenger molecule with diverse functions throughout the body...
  
  ,
• RASD1
  RASD1
  Dexamethasone-induced Ras-related protein 1 is a protein that in humans is encoded by the RASD1 gene.-Further reading:...
  
  ,
• SYN1