Nuclear pore complex protein Nup214 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the NUP214 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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The nuclear pore

Nuclear pore

Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus. There are about on average 2000 nuclear pore complexes in the nuclear envelope of a vertebrate cell, but it varies depending on cell type and the stage in...

 complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecule

Macromolecule

A macromolecule is a very large molecule commonly created by some form of polymerization. In biochemistry, the term is applied to the four conventional biopolymers , as well as non-polymeric molecules with large molecular mass such as macrocycles...

s between the nucleus and the cytoplasm

Cytoplasm

The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...

. Nucleoporin

Nucleoporin

The nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the...

s are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle

Cell cycle

The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...

 progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene

DEK (gene)

Protein DEK is a protein that in humans is encoded by the DEK gene.-Interactions:DEK has been shown to interact with TFAP2A.-Further reading:...

 on chromosome 6 in a t(6,9) translocation

Chromosomal translocation

In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise separated genes, the occurrence of which is common in cancer. It is detected on...

 associated with acute myeloid leukemia

Acute myeloid leukemia

Acute myeloid leukemia , also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute...

 and myelodysplastic syndrome

Myelodysplastic syndrome

The myelodysplastic syndromes are a diverse collection of hematological medical conditions that involve ineffective production of the myeloid class of blood cells....

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Interactions

NUP214 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with NXF2

NXF2

Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.-Further reading:...

, ZFP36

ZFP36

Tristetraprolin also known as zinc finger protein 36 homolog is a protein that in humans is encoded by the ZFP36 gene....

 and NXF1

NXF1

Nuclear RNA export factor 1, also known as NXF1, is a protein which in humans is encoded by the NXF1 gene.-Function:This gene is one member of a family of nuclear RNA export factor genes...

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Further reading