North China Pharmaceutical Group Corp
Encyclopedia
North China Pharmaceutical Group Corp. (NCPC), is a leading pharmaceutical manufacturer in China
. NCPC, in its early days, was one of the key construction projects during Chinese First Five-Year Plan
. After fiver years of construction from the foundation date in June 1953, the successful operation started in June 1958. Being one of the world leading antibiotic
producers both in technology and production scale at that time, NCPC created a history of commercial production of antibiotics in China. With 45 years development, NCPC has been continually growing and taking the lead in China pharmaceutical industry in key economic indexes, ranking one of the Top500 Enterprises and the best profit-makers in China. By the end of 2002, the total assets is USD2 billion, number of employees 18500. In 2002, NCPC achieved domestic sales revenue USD 700million and export sales USD100million. Sticking to the spirit of "Service for Life ", NCPC is willing to build bright future for all the people.
with 59.87% of shaires held by NCPC. NCPC is one of the four groups of the candidate enterprises approved by China Securities Regulatory Commission
for overseas listing. Keeping in close cooperation with foreign companies and institutions, NCPC has established 16 joint ventures and cooperative ventures.
s, semi-synthetic antibiotics, pharmaceutical intermediates, vitamin
s, biotechnology
products, veterinary and neutraceuticals both in bulk and in finished products. NCPC sells bulk antibiotics 7000 tons, vitamins 10000 tons, antibiotic intermediates 7500 tons, powder for injection 1.8 billion vials, capsules 1.03 billion grains annually. The capacity of penicillin
, streptomycin
, 6-APA
, amoxycillin, cefaradine, vitamin B100 are in the lead worldwide. NCPC's next development focus is on biotechnology products, bio-pesticides and animal products. Since 1984, NCPC has initiated research on modern biotechnology and formed the system for developing generic drug
involving new products R&D, pilot production and commercial production. In cooperation with the foreign companies, NCPC has completed the design and construction of GeneTech Biotechnology Co., Ltd. who is now a modern biotechnology production base in line with international practice and standards. There are rhGM-CSF, rhG-CSF, EPO
and Hepatitis B Vaccine
(CHO
) on market at present.
and quality assurance
system. All of the processes in the production comply with the current GMP. The major production lines have passed the national GMP
audit
. The technology of NCPC's main products is in the leading position in China. Application of the latest technology and international advanced equipment ensures the stability of the production process and the product quality. NCPC was the first one in China who applied computer aided production management to fermentation
process control. The CIMS Project of NCPC Beta Co., Ltd. has been awarded the National Model Project. NCPC has a Central QC Center of 7000 square meters with the advanced equipment and methods to control the quality in every production section. Through 20 years of TQM
and unremitting efforts in quality improvement, an efficient quality assurance system has been established to guarantee the best quality of the products. In 2001, the trademark
of NCPC was evaluated to be worth USD461million.
, kasugamycin
, bleomycin
, amphotericin B
, lindomycin, clindamycin
, clindamycin phosphate and norvancomycin. NCPC New Drug R&D Co., Ltd. is responsible for the new drug and technology development of the whole NCPC Group. Nearly 300 experts and technicians, advanced instruments and integrated pilot unit make it possible to transform laboratory reactions into large-scale production. In recent 10 years, R&D investment of NCPC kept occupying over 30% of sales volume annually. Based on the long-term abundant input, NCPC has new products put into market every year. NCPC has been transferring from generic imitation into original research in new drug development and forming a development platform of its own. Its original research focuses on the natural and small molecular drugs screening, combinatorial chemical technology and modern biotechnology.
China
Chinese civilization may refer to:* China for more general discussion of the country.* Chinese culture* Greater China, the transnational community of ethnic Chinese.* History of China* Sinosphere, the area historically affected by Chinese culture...
. NCPC, in its early days, was one of the key construction projects during Chinese First Five-Year Plan
Five-Year Plans of China
The five-year plans of People's Republic of China are a series of economic development initiatives. The economy was shaped by the Communist Party of China through the plenary sessions of the Central Committee and national congresses...
. After fiver years of construction from the foundation date in June 1953, the successful operation started in June 1958. Being one of the world leading antibiotic
Antibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
producers both in technology and production scale at that time, NCPC created a history of commercial production of antibiotics in China. With 45 years development, NCPC has been continually growing and taking the lead in China pharmaceutical industry in key economic indexes, ranking one of the Top500 Enterprises and the best profit-makers in China. By the end of 2002, the total assets is USD2 billion, number of employees 18500. In 2002, NCPC achieved domestic sales revenue USD 700million and export sales USD100million. Sticking to the spirit of "Service for Life ", NCPC is willing to build bright future for all the people.
Organization
NCPC now has 29 subsidiaries. Among which North China Pharmaceutical Co., Ltd. is a listed company at Shanghai Stock ExchangeShanghai Stock Exchange
The Shanghai Stock Exchange , abbreviated as 上证所/上證所 or 上交所, is a stock exchange that is based in the city of Shanghai, China. It is one of the two stock exchanges operating independently in the People's Republic of China, the other is the Shenzhen Stock Exchange...
with 59.87% of shaires held by NCPC. NCPC is one of the four groups of the candidate enterprises approved by China Securities Regulatory Commission
China Securities Regulatory Commission
The China Securities Regulatory Commission is an institution of the State Council of the People's Republic of China , with ministry-level rank...
for overseas listing. Keeping in close cooperation with foreign companies and institutions, NCPC has established 16 joint ventures and cooperative ventures.
Products
NCPC currently produces over 430 kinds of antibioticAntibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
s, semi-synthetic antibiotics, pharmaceutical intermediates, vitamin
Vitamin
A vitamin is an organic compound required as a nutrient in tiny amounts by an organism. In other words, an organic chemical compound is called a vitamin when it cannot be synthesized in sufficient quantities by an organism, and must be obtained from the diet. Thus, the term is conditional both on...
s, biotechnology
Biotechnology
Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bioproducts. Biotechnology also utilizes these products for manufacturing purpose...
products, veterinary and neutraceuticals both in bulk and in finished products. NCPC sells bulk antibiotics 7000 tons, vitamins 10000 tons, antibiotic intermediates 7500 tons, powder for injection 1.8 billion vials, capsules 1.03 billion grains annually. The capacity of penicillin
Penicillin
Penicillin is a group of antibiotics derived from Penicillium fungi. They include penicillin G, procaine penicillin, benzathine penicillin, and penicillin V....
, streptomycin
Streptomycin
Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin is a bactericidal antibiotic. Streptomycin cannot be given...
, 6-APA
6-APA
6-APA is the chemical compound -6-aminopenicillanic acid.-Use:6-APA is the core of penicillins. It is obtained from the fermentation brew of the Penicillium mold and used as the main starting block for the preparation of numerous semisynthetic penicillins.-Manufacture:This useful compound is made...
, amoxycillin, cefaradine, vitamin B100 are in the lead worldwide. NCPC's next development focus is on biotechnology products, bio-pesticides and animal products. Since 1984, NCPC has initiated research on modern biotechnology and formed the system for developing generic drug
Generic drug
A generic drug is a drug defined as "a drug product that is comparable to brand/reference listed drug product in dosage form, strength, route of administration, quality and performance characteristics, and intended use." It has also been defined as a term referring to any drug marketed under its...
involving new products R&D, pilot production and commercial production. In cooperation with the foreign companies, NCPC has completed the design and construction of GeneTech Biotechnology Co., Ltd. who is now a modern biotechnology production base in line with international practice and standards. There are rhGM-CSF, rhG-CSF, EPO
Erythropoietin
Erythropoietin, or its alternatives erythropoetin or erthropoyetin or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production...
and Hepatitis B Vaccine
Hepatitis B vaccine
Hepatitis B vaccine is a vaccine developed for the prevention of hepatitis B virus infection. The vaccine contains one of the viral envelope proteins, hepatitis B surface antigen . It is produced by yeast cells, into which the genetic code for HBsAg has been inserted...
(CHO
Cho
Cho or CHO can refer to several things:Cho can refer to the following people, real or fictional:-People:Given name* Cho Ramaswamy, an actor, columnist, and political commentator in Tamil Nadu, India* Cho U, a Chinese Go playerSurname...
) on market at present.
QC & QA
NCPC established a rigorous and efficient quality controlQuality control
Quality control, or QC for short, is a process by which entities review the quality of all factors involved in production. This approach places an emphasis on three aspects:...
and quality assurance
Quality Assurance
Quality assurance, or QA for short, is the systematic monitoring and evaluation of the various aspects of a project, service or facility to maximize the probability that minimum standards of quality are being attained by the production process...
system. All of the processes in the production comply with the current GMP. The major production lines have passed the national GMP
Good Manufacturing Practice
"Good manufacturing practice" or "GMP" are practices and the systems required to be adapted in pharmaceutical manufacturing, quality control, quality system covering the manufacture and testing of pharmaceuticals or drugs including active pharmaceutical ingredients, diagnostics, foods,...
audit
Audit
The general definition of an audit is an evaluation of a person, organization, system, process, enterprise, project or product. The term most commonly refers to audits in accounting, but similar concepts also exist in project management, quality management, and energy conservation.- Accounting...
. The technology of NCPC's main products is in the leading position in China. Application of the latest technology and international advanced equipment ensures the stability of the production process and the product quality. NCPC was the first one in China who applied computer aided production management to fermentation
Industrial fermentation
Industrial fermentation is the intentional use of fermentation by microorganisms such as bacteria and fungi to make products useful to humans. Fermented products have applications as food as well as in general industry.- Food fermentation :...
process control. The CIMS Project of NCPC Beta Co., Ltd. has been awarded the National Model Project. NCPC has a Central QC Center of 7000 square meters with the advanced equipment and methods to control the quality in every production section. Through 20 years of TQM
Total Quality Management
Total quality management or TQM is an integrative philosophy of management for continuously improving the quality of products and processes....
and unremitting efforts in quality improvement, an efficient quality assurance system has been established to guarantee the best quality of the products. In 2001, the trademark
Trademark
A trademark, trade mark, or trade-mark is a distinctive sign or indicator used by an individual, business organization, or other legal entity to identify that the products or services to consumers with which the trademark appears originate from a unique source, and to distinguish its products or...
of NCPC was evaluated to be worth USD461million.
R&D
R&D As an enterprise with excellent abilities for independent research and development, NCPC was the first in China to succeed in developing dozen of new products: such as bacitracinBacitracin
Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, isolation of which was first reported in 1945....
, kasugamycin
Kasugamycin
Kasugamycin is an aminoglycoside antibiotic that was originally isolated in 1965, from Streptomyces kasugaensis, a Streptomyces strain found near the Kasuga shrine in Nara, Japan. Kasugamycin was discovered by Hamao Umezawa, who also discovered kanamycin and bleomycin, as a drug which could...
, bleomycin
Bleomycin
Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. Bleomycin refers to a family of structurally related compounds. When used as an anticancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2. It works by causing breaks in DNA...
, amphotericin B
Amphotericin B
Amphotericin B is a polyene antifungal drug, often used intravenously for systemic fungal infections...
, lindomycin, clindamycin
Clindamycin
Clindamycin rINN is a lincosamide antibiotic. It is usually used to treat infections with anaerobic bacteria but can also be used to treat some protozoal diseases, such as malaria...
, clindamycin phosphate and norvancomycin. NCPC New Drug R&D Co., Ltd. is responsible for the new drug and technology development of the whole NCPC Group. Nearly 300 experts and technicians, advanced instruments and integrated pilot unit make it possible to transform laboratory reactions into large-scale production. In recent 10 years, R&D investment of NCPC kept occupying over 30% of sales volume annually. Based on the long-term abundant input, NCPC has new products put into market every year. NCPC has been transferring from generic imitation into original research in new drug development and forming a development platform of its own. Its original research focuses on the natural and small molecular drugs screening, combinatorial chemical technology and modern biotechnology.