Ocinaplon
Encyclopedia
Ocinaplon is an anxiolytic
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...

 drug in the pyrazolopyrimidine
Pyrazolopyrimidine
Pyrazolopyrimidine is a heterocyclic chemical compound with the molecular formula C6H5N3. It forms the central core of a variety of more complex chemical compounds including some pharmaceuticals and pesticides.-Pharmaceuticals:...

 family of drugs. Other pyrazolopyrimidine drugs include zaleplon
Zaleplon
Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. In terms of adverse effects zaleplon appears to offer little improvement compared to both benzodiazepines and other non-benzodiazepine Z-drugs.Sonata is manufactured by...

 and indiplon
Indiplon
Indiplon is a nonbenzodiazepine, hypnotic sedative being developed in 2 formulations - an immediate release product for sleep onset and a modified-release version for sleep maintenance.- Mode of action :...

.

Ocinaplon has a similar pharmacological profile to the benzodiazepine
Benzodiazepine
A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...

 family of drugs, but with mainly anxiolytic properties and relatively little sedative
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....

 or amnestic effect.

Mechanism of action

The mechanism of action by which ocinaplon produces its anxiolytic effects is by modulating GABAA receptors, although ocinaplon is more subtype-selective than most benzodiazepines.

Availability

Development of ocinaplon is discontinued due to liver complications that occurred in one of the Phase III subjects.
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