PATRIC
Encyclopedia
PATRIC, the Pathosystems Resource Integration Center, is one of the four Bioinformatics Resource Centers
(BRC) funded by the National Institutes of Allergy and Infectious Diseases, NIAID a component of the National Institutes of Health
(NIH), which is an agency of the United States Department of Health and Human Services
. PATRIC integrates information and tools for all bacterial species in the selected NIAID category A-C priority pathogens list to help researchers analyze genomic, proteomic and other data arising from infectious disease research.
Bioinformatics Resource Centers
The Bioinformatics Resource Centers are a group of five Internet-based research centers established in 2004 and funded by NIAID The BRCs were formed in response to the threats posed by emerging and re-emerging pathogens, particularly CDC Category A, B, and C pathogens, and their potential use in...
(BRC) funded by the National Institutes of Allergy and Infectious Diseases, NIAID a component of the National Institutes of Health
National Institutes of Health
The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
(NIH), which is an agency of the United States Department of Health and Human Services
United States Department of Health and Human Services
The United States Department of Health and Human Services is a Cabinet department of the United States government with the goal of protecting the health of all Americans and providing essential human services. Its motto is "Improving the health, safety, and well-being of America"...
. PATRIC integrates information and tools for all bacterial species in the selected NIAID category A-C priority pathogens list to help researchers analyze genomic, proteomic and other data arising from infectious disease research.
Bacterial organisms covered in the PATRIC database
- BacillusBacillusBacillus is a genus of Gram-positive, rod-shaped bacteria and a member of the division Firmicutes. Bacillus species can be obligate aerobes or facultative anaerobes, and test positive for the enzyme catalase. Ubiquitous in nature, Bacillus includes both free-living and pathogenic species...
- BartonellaBartonellaBartonella is a genus of Gram-negative bacteria. Facultative intracellular parasites, Bartonella species can infect healthy people but are considered especially important as opportunistic pathogens. Bartonella are transmitted by insect vectors such as ticks, fleas, sand flies and mosquitoes...
- BorreliaBorreliaBorrelia is a genus of bacteria of the spirochete phylum. It causes borreliosis, a zoonotic, vector-borne disease transmitted primarily by ticks and some by lice, depending on the species...
- BrucellaBrucellaBrucella is a genus of Gram-negative bacteria. They are small , non-motile, non-encapsulated coccobacilli, which function as facultative intracellular parasites....
- BurkholderiaBurkholderiaBurkholderia is a genus of proteobacteria probably best known for its pathogenic members:Burkholderia mallei, responsible for glanders, a disease that occurs mostly in horses and related animals;...
- CampylobacterCampylobacterCampylobacter is a genus of bacteria that are Gram-negative, spiral, and microaerophilic. Motile, with either unipolar or bipolar flagella, the organisms have a characteristic spiral/corkscrew appearance and are oxidase-positive. Campylobacter jejuni is now recognized as one of the main causes...
- ChlamydophilaChlamydophilaChlamydophila is a bacterial genus belonging to the family Chlamydiaceae, order Chlamydiales, class/phylum Chlamydiae.-Taxonomy:Chlamydophila was recognized in 1999, with six species in Chlamydophila and three in the original genus, Chlamydia...
- ClostridiumClostridiumClostridium is a genus of Gram-positive bacteria, belonging to the Firmicutes. They are obligate anaerobes capable of producing endospores. Individual cells are rod-shaped, which gives them their name, from the Greek kloster or spindle...
- CoxiellaCoxiellaCoxiella refers to a genus of Gram-negative bacteria in the family Coxiellaceae. It is named after Harold Herald Rea Cox , an American bacteriologist. Coxiella burnetii is the only member of this genus...
- EhrlichiaEhrlichiaEhrlichia is a genus of rickettsiales bacteria. They are transmitted by ticks. Several species can cause infection in humans. The genus is named after German microbiologist Paul Ehrlich...
- EscherichiaEscherichiaEscherichia is a genus of Gram-negative, non-spore forming, facultatively anaerobic, rod-shaped bacteria from the family Enterobacteriaceae. In those species which are inhabitants of the gastrointestinal tracts of warm-blooded animals, Escherichia species provide a portion of the...
- FrancisellaFrancisellaFrancisella is a genus of pathogenic, Gram-negative bacteria. They are small coccobacillary or rod-shaped, non-motile organisms, which are also facultative intracellular parasites of macrophages...
- HelicobacterHelicobacterHelicobacter is a genus of Gram-negative bacteria possessing a characteristic helix shape. They were initially considered to be members of the Campylobacter genus, but since 1989 they have been grouped in their own genus...
- Lysteria
- MycobacteriumMycobacteriumMycobacterium is a genus of Actinobacteria, given its own family, the Mycobacteriaceae. The genus includes pathogens known to cause serious diseases in mammals, including tuberculosis and leprosy...
- RickettsiaRickettsiaRickettsia is a genus of non-motile, Gram-negative, non-sporeforming, highly pleomorphic bacteria that can present as cocci , rods or thread-like . Being obligate intracellular parasites, the Rickettsia survival depends on entry, growth, and replication within the cytoplasm of eukaryotic host cells...
- SalmonellaSalmonellaSalmonella is a genus of rod-shaped, Gram-negative, non-spore-forming, predominantly motile enterobacteria with diameters around 0.7 to 1.5 µm, lengths from 2 to 5 µm, and flagella which grade in all directions . They are chemoorganotrophs, obtaining their energy from oxidation and reduction...
- ShigellaShigellaShigella is a genus of Gram-negative, nonspore forming, non-motile, rod-shaped bacteria closely related to Escherichia coli and Salmonella. The causative agent of human shigellosis, Shigella causes disease in primates, but not in other mammals. It is only naturally found in humans and apes. During...
- StaphylococcusStaphylococcusStaphylococcus is a genus of Gram-positive bacteria. Under the microscope they appear round , and form in grape-like clusters....
- VibrioVibrioVibrio is a genus of Gram-negative bacteria possessing a curved rod shape, several species of which can cause foodborne infection, usually associated with eating undercooked seafood. Typically found in saltwater, Vibrio are facultative anaerobes that test positive for oxidase and do not form...
- YersiniaYersiniaYersinia is a genus of bacteria in the family Enterobacteriaceae. Yersinia are Gram-negative rod shaped bacteria, a few micrometers long and fractions of a micrometer in diameter, and are facultative anaerobes. Some members of Yersinia are pathogenic in humans; in particular, Y. pestis is the...
- Other BacteriaBacteriaBacteria are a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals...
Tools available through the PATRIC site
- Genome browser
- Comparative Pathway Tool
- Protein Family Sorter
- BLAST
- RAST prokaryotic genome annotation service
- KLEIO advanced MedLine search tool
External links
- Bioinformatics Resource Centers The NIAID page describing the goals and activities of the BRCs
- Pathogen Portal Hub site for the five BRCs; provides cross-BRC summary information