Phosphofructokinase, platelet, also known as PFKP is an enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

 which in humans is encoded by the PFKP gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

The PFKP gene encodes the platelet isoform of phosphofructokinase

Phosphofructokinase

Phosphofructokinase-1 is the most important regulatory enzyme of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by many activators and inhibitors...

 (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose 6-phosphate

Fructose 6-phosphate

Fructose 6-phosphate is fructose sugar phosphorylated on carbon 6 . The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to this at some point...

 to fructose 1,6-bisphosphate

Fructose 1,6-bisphosphate

Fructose 1,6-bisphosphate is fructose sugar phosphorylated on carbons 1 and 6 . The β-D-form of this compound is very common in cells...

 and is a key regulatory enzyme in glycolysis

Glycolysis

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+...

. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM

PFKM

6-phosphofructokinase, muscle type is an enzyme that in humans is encoded by the PFKM gene.-Further reading:...

) and liver (PFKL

PFKL

6-phosphofructokinase, liver type is an enzyme that in humans is encoded by the PFKL gene.-Further reading:...

) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.

Further reading