Pennsylvania Route 49 is a 53 miles (85.3 km) long state highway

State highway

State highway, state road or state route can refer to one of three related concepts, two of them related to a state or provincial government in a country that is divided into states or provinces :#A...

 located in northern Pennsylvania

Pennsylvania

The Commonwealth of Pennsylvania is a U.S. state that is located in the Northeastern and Mid-Atlantic regions of the United States. The state borders Delaware and Maryland to the south, West Virginia to the southwest, Ohio to the west, New York and Ontario, Canada, to the north, and New Jersey to...

. The western terminus of the route is at Pennsylvania Route 44

Pennsylvania Route 44

Pennsylvania Route 44 is a -long state highway in the U.S. state of Pennsylvania. The route is designated from Interstate 80 and Pennsylvania Route 42 in Buckhorn to the New York state line near New York State Route 417 in Ceres Township....

 three miles (5 km) north of Coudersport

Coudersport, Pennsylvania

Coudersport is a borough in Potter County, Pennsylvania, east by south of Erie on the Allegheny River. The populations were these: 1,530 in 1890; 3,217 in 1900; and 3,100 in 1910. The population was 2,650 at the 2000 census...

. The eastern terminus is at PA 287

Pennsylvania Route 287

Pennsylvania Route 287 is a long state highway in the Tioga Valley of Pennsylvania. Route 287 begins at an intersection with U.S. Route 220 in the community of Larrys Creek in Piatt Township, Lycoming County to an intersection with Pennsylvania Route 49 just south of the New York state line...

 in Lawrenceville

Lawrenceville, Pennsylvania

Lawrenceville is a borough in Tioga County, Pennsylvania, in the United States. The population was 627 at the 2000 census.-Geography:Lawrenceville is located at . It is at the intersection of Pennsylvania Route 287 and Pennsylvania Route 49. The only traffic light in town can be found at this...

 less than 300 yards (274.3 m) south of the New York-Pennsylvania border. PA 49 serves as North Street, North Main Street, and Northern Potter Road in Ulysses

Ulysses, Pennsylvania

Ulysses is a borough in Potter County, Pennsylvania, United States. The population was 684 at the 2000 census. When first settled, in 1831, Ulysses was named Lewisville, after an early settler, Orange Lewis. Orange Lewis was a prominent farmer who later became Justice of the Peace, and then county...

, as Cowanesque Street in Lawrenceville, and as both East and West Main Street for Harrison Valley, Westfield

Westfield, Pennsylvania

Westfield is a borough in Tioga County, Pennsylvania, in the United States. The population was 1,190 at the 2000 census.-Geography:Westfield is located at ....

, Knoxville

Knoxville, Pennsylvania

Knoxville is a borough in Tioga County, Pennsylvania, in the United States. The population was 617 at the 2000 census.-Geography:Knoxville is located at ....

, and Elkland

Elkland, Pennsylvania

Elkland is a borough in Tioga County, Pennsylvania, in the United States. The population was 1,786 at the 2000 census.-Geography:Elkland is located at ....

. It is concurrent with PA 249

Pennsylvania Route 249

Pennsylvania Route 249 is an long state highway located in Tioga county in Pennsylvania. The southern terminus is at PA 287 in Middlebury Township...

 for 2.5 miles (4 km) between Cowanesque and Knoxville.

Major intersections