Peroxin
Encyclopedia
Peroxin is a protein found in peroxisome
s.
Deficiencies are associated with several peroxisomal disorder
s.
Numerous peroxin proteins serve several functions including the recognition of cytoplasmic proteins that contain peroxisomal targeting signals (PTS) that tag them for transport by peroxisomal proteins to the peroxisome.
"PEX2" is now known as "peroxisomal membrane protein 3", or .
Peroxisome
Peroxisomes are organelles found in virtually all eukaryotic cells. They are involved in the catabolism of very long chain fatty acids, branched chain fatty acids, D-amino acids, polyamines, and biosynthesis of plasmalogens, etherphospholipids critical for the normal function of mammalian brains...
s.
Deficiencies are associated with several peroxisomal disorder
Peroxisomal disorder
Peroxisomal disorders represent a class of medical conditions caused by defects in peroxisome functions. This may be due to defects in single enzymes important for peroxisome function or in peroxins, proteins encoded by PEX genes that are critical for normal peroxisome assembly and...
s.
Numerous peroxin proteins serve several functions including the recognition of cytoplasmic proteins that contain peroxisomal targeting signals (PTS) that tag them for transport by peroxisomal proteins to the peroxisome.
Genes
- PEX1PEX1Peroxisome biogenesis factor 1, also known as PEX1, is a protein which in humans is encoded by the PEX1 gene.This gene encodes a member of the AAA protein family, a large group of ATPases associated with diverse cellular activities...
- PEX3PEX3Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the PEX3 gene.-External Links:* *...
- PEX5PEX5Peroxisomal targeting signal 1 receptor is a protein that in humans is encoded by the PEX5 gene.-Interactions:PEX5 has been shown to interact with PEX12, PEX13 and PEX14.-External Links:* *...
- PEX6PEX6Peroxisome assembly factor 2 is a protein that in humans is encoded by the PEX6 gene.-Interactions:PEX6 has been shown to interact with PEX1 and PEX26.-External Links:* *...
- PEX7 (see also peroxin-7Peroxin-7Peroxin-7 is a receptor associated with Refsum's disease and rhizomelic chondrodysplasia punctata type 1.-External links:* *...
) - PEX10PEX10Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene.- Function :Peroxisome biogenesis factor 10 os involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane...
- PEX11APEX11APeroxisomal membrane protein 11A is a protein that in humans is encoded by the PEX11A gene.-Further reading:...
, PEX11BPEX11BPeroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene. It is involved in the regulation of peroxisome abundance.-Related gene problems:*TAR syndrome*1q21.1 deletion syndrome*1q21.1 duplication syndrome...
, PEX11GPEX11GPEX11G is a human gene that encodes the peroxisomal biogenesis factor 11 gamma for peroxisomes. It is located on chromosome 19.... - PEX12PEX12Peroxisome assembly protein 12 is a protein that in humans is encoded by the PEX12 gene.- Function :The peroxisome biogenesis disorders are a group of genetically heterogeneous diseases that are usually lethal in early infancy...
- PEX13PEX13Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene.. It located on chromosome 2 next to KIAA1841-Interactions:PEX13 has been shown to interact with PEX14, PEX5 and PEX19.-External Links:* *...
- PEX14PEX14Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.-Interactions:PEX14 has been shown to interact with* PEX5* PEX7* PEX13-External Links:* *...
- PEX16PEX16Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.- Function :The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the...
- PEX19PEX19Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.-Interactions:PEX19 has been shown to interact with PEX10, PEX12, PEX13, ABCD3, ABCD1, PEX3, ABCD2, PEX11B and PEX16.-External Links:* *...
- PEX26PEX26Peroxisome assembly protein 26 is a protein that in humans is encoded by the PEX26 gene.-Interactions:PEX26 has been shown to interact with PEX1, PEX6 and SUFU.-External Links:* *...
"PEX2" is now known as "peroxisomal membrane protein 3", or .