Pho4
Encyclopedia
Pho4 is a basic-helix-loop-helix
(bHLH) transcription factor
found in S. cerevisiae
and other yeasts.
The Pho4 homodimer binds to DNA
sequences containing the bHLH binding site 5'-CACGTG-3'. This sequence is found in the promoters of genes upregulated in response to phosphate
availability such as the PHO5 gene.
Basic-helix-loop-helix
A basic helix-loop-helix is a protein structural motif that characterizes a family of transcription factors.- Structure :The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino...
(bHLH) transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
found in S. cerevisiae
Saccharomyces cerevisiae
Saccharomyces cerevisiae is a species of yeast. It is perhaps the most useful yeast, having been instrumental to baking and brewing since ancient times. It is believed that it was originally isolated from the skin of grapes...
and other yeasts.
The Pho4 homodimer binds to DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
sequences containing the bHLH binding site 5'-CACGTG-3'. This sequence is found in the promoters of genes upregulated in response to phosphate
Phosphate
A phosphate, an inorganic chemical, is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry and biogeochemistry or ecology. Inorganic phosphates are mined to obtain phosphorus for use in...
availability such as the PHO5 gene.