Piers David Nash is a scientist

Scientist

A scientist in a broad sense is one engaging in a systematic activity to acquire knowledge. In a more restricted sense, a scientist is an individual who uses the scientific method. The person may be an expert in one or more areas of science. This article focuses on the more restricted use of the word...

 who investigates protein-protein interactions involved in signal transduction

Signal transduction

Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor. In turn, this receptor alters intracellular molecules creating a response...

, and the molecular mechanisms by which cells respond to external cues. He is the son of Roger Nash

Roger Nash

Roger Nash BA, MA, PhD is a Canadian philosopher and poet. He was born in Maidenhead, Berkshire, England on November 3, 1942. He grew up in England, Egypt, Cyprus, Singapore and Hong Kong. He has a B.A. from the University of Wales , an M.A. from McMaster University and a Ph.D...

 and Chris Nash (Bronwen Christine Harrhy), and brother of Caedmon Nash.

He is an Assistant Professor in The Ben May Department for Cancer Research and a Scientist of the Comprehensive Cancer Center at The University of Chicago since 2004. His work focuses on understanding the SH2 domain

SH2 domain

The SH2 domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins...

 at a systems level and investigating the role of ubiquitination in controlling endocytosis

Endocytosis

Endocytosis is a process by which cells absorb molecules by engulfing them. It is used by all cells of the body because most substances important to them are large polar molecules that cannot pass through the hydrophobic plasma or cell membrane...

 and modulating signal transduction

Signal transduction

Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor. In turn, this receptor alters intracellular molecules creating a response...

.

Born in Exeter

Exeter

Exeter is a historic city in Devon, England. It lies within the ceremonial county of Devon, of which it is the county town as well as the home of Devon County Council. Currently the administrative area has the status of a non-metropolitan district, and is therefore under the administration of the...

, England

England

England is a country that is part of the United Kingdom. It shares land borders with Scotland to the north and Wales to the west; the Irish Sea is to the north west, the Celtic Sea to the south west, with the North Sea to the east and the English Channel to the south separating it from continental...

, he received a B.Sc.

Bachelor of Science

A Bachelor of Science is an undergraduate academic degree awarded for completed courses that generally last three to five years .-Australia:In Australia, the BSc is a 3 year degree, offered from 1st year on...

 in Biochemistry from the University of Guelph

University of Guelph

The University of Guelph, also known as U of G, is a comprehensive public research university in Guelph, Ontario, Canada. It was established in 1964 after the amalgamation of Ontario Agricultural College, the Macdonald Institute, and the Ontario Veterinary College...

. He received a Ph.D

Doctor of Philosophy

Doctor of Philosophy, abbreviated as Ph.D., PhD, D.Phil., or DPhil , in English-speaking countries, is a postgraduate academic degree awarded by universities...

 in 1999 from the University of Alberta

University of Alberta

The University of Alberta is a public research university located in Edmonton, Alberta, Canada. Founded in 1908 by Alexander Cameron Rutherford, the first premier of Alberta and Henry Marshall Tory, its first president, it is widely recognized as one of the best universities in Canada...

 working in the laboratory of Dr. Grant McFadden investigating poxviral immunomodulatory proteins. His doctoral thesis focused on the enzymology and biological properties of the Myxoma virus

Myxomatosis

Myxomatosis is a disease that affects rabbits and is caused by the Myxoma virus. It was first observed in Uruguay in laboratory rabbits in the late 19th century. It was introduced into Australia in 1950 in an attempt to control the rabbit population...

 encoded serine proteinase inhibitor (serpin

Serpin

Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases .The first members of the serpin superfamily to be extensively...

), SERP-1. He completed postdoctoral research with Dr. Tony Pawson

Anthony Pawson

Anthony 'Tony' James Pawson, OC, OOnt, CH, FRS, FRSC , British-born Canadian scientist whose research has revolutionized the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other...

 at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital

Mount Sinai Hospital (Toronto)

Mount Sinai Hospital is a hospital in Toronto, Ontario, Canada. Although it is physically linked by bridges and tunnels to two University Health Network hospitals , Mount Sinai is an independently operated facility...

 and the University of Toronto

University of Toronto

The University of Toronto is a public research university in Toronto, Ontario, Canada, situated on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution of higher learning in Upper Canada...

 from June 1999 to December 2003.

Research Papers

• Nash, P. (1984). "Differential Effects of Wind Speed on Low Temperature Evaporation", Chinook 6: 92-93.
• Nash, C. H., and Nash, P. (1986). "Correlates of Colour Memory: A Neglected Field of Research", Future Health 8: 15-16.
• Nash, P., and Davison, L. (1989). "What gifted secondary school students tell about their school programs", Canadian Journal of Education. 14: 109-118.
• Maksymowych, W. P., Nation, N., Nash, P., Macen, J., McFadden, G., Lucas, A., and Russell, A. S. (1996). Amelioration of established antigen-induced arthritis in rabbits treated with a secreted viral serine proteinase inhibitor. Journal of Rheumatology 23 (5): 878-882.
• Lucas, A., Liu, L., Macen, J. L., Nash, P., Dai, E., Stewart, M., Yan, W., Graham, K., Etches, W., Boshkov, L., Nation, P. N., Humen, D., Hobman, M., and McFadden, G. (1996). A virus-encoded serine proteinase inhibitor, SERP-1, inhibits atherosclerotic plaque development following balloon angioplasty. Circulation, 94 (11): 2890-2900.
• Nash, P., Whitty, A., Handwerker, J., Macen, J., and McFadden, G. (1998) Inhibitory specificity of the anti-inflammatory myxoma virus serpin, SERP-1. Journal of Biological Chemistry
  Journal of Biological Chemistry
  The Journal of Biological Chemistry is a weekly peer-reviewed scientific journal that was established in 1905. Since 1925 it is published by the American Society for Biochemistry and Molecular Biology. It covers research in any area of biochemistry or molecular biology. The editor-in-chief is...
  
   273 (33): 20982-20991. http://www.jbc.org/cgi/content/full/273/33/20982
• Christov, A., Dai, E., Liu, L., Miller, L.W., Nash, P., Lalani, A., McFadden, G., Nation, P.N., Tulip, J., and Lucas, A. (1999). Detection of transplant vasculopathy in a rat aortic allograft model by fluorescence spectroscopic optical analysis. Lasers in Surgery and Medicine 24: 346-359.
• Miller, L., Dai, E., Nash, P., Liu, L., Icton, C., Klironomous, D., Fan, L., Nation, P. N., Zhong, R., McFadden, G., Lucas, A. (2000) Inhibition of transplant vasculopathy in a rat aortic model after infusion of an anti-inflammatory viral serpin. Circulation 101: 1598-1605.
• Lucas, A., Dai, E., Liu, L., Guan, H., Nash, P., Mcfadden, G., Miller, L. (2000) Transplant vasculopathy: viral anti-inflammatory serpin regulation of atherogenesis. The Journal of Heart and Lung Transplantation 19: 1029-1038.
• Nash, P., Barry, M., Seet, B., Jahns, K., Hota, S., Heger, J., Hodgkinson, C., Graham, K., Jackson, R., McFadden, G. (2000) Post-translational modification of the myxoma virus anti-inflammatory serpin, SERP-1. Biochemical Journal 347: 375-382.
• Christov, A., Dai, E., Drangova, M., Liu, L., Abela, G.S., Nash, P., McFadden, G. and Lucas, A. (2000) Optical Detection of Triggered Atherosclerotic Plaque Disruption by Fluorescence Emission Analysis. Photochemistry and Photobiology, 72 (2): 242–252
• Nash, P., McFadden, G. and Whitty, A. (2000) The application of linear free energy relationships to SERPIN mechanism. FEBS Letters 475: 1-6.
• Nash, P., Tang, X., Orlicky, S., Chen, Q., Gertler, F.B., Mendenhall, M.D., Sicheri, F., Pawson, T., Tyers, M. (2001) Multi-site phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature
  Nature (journal)
  Nature, first published on 4 November 1869, is ranked the world's most cited interdisciplinary scientific journal by the Science Edition of the 2010 Journal Citation Reports...
  
   414: 514-521. http://www.nature.com/nature/journal/v414/n6863/abs/414514a.html

This article was the focus of the following reviews and comments:
Ferrell, J. E. Jr. (2001) Six steps to destruction Nature 414: 498-499. http://www.nature.com/nature/journal/v414/n6863/full/414498b.html
Deshaies, R.J. and Ferrell, J. E. Jr. (2002) Multisite Phosphorylation and the Countdown to S Phase. Cell

Cell (journal)

Cell is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research,...

 107: 819-822. http://www.cell.com/content/article/abstract?uid=PIIS0092867401006201
Harper, J. W. (2002) A phosphorylation-driven ubiquitination switch for cell-cycle control. Trends in Cell Biology 12(3): 104-107.
Tromans, A. (2001) Highlights of the Week: Switching on S-Phase. Nature Reviews Molecular Cell Biology 2:873.
Adler, E.M. Gough, N.R., Ray, L.B. (2004) 2003:Signaling Breakthroughs of the Year. Sci. STKE 2004: 214, eg1.

• Nash, P., Berry, D., Liu, S., Pawon, T., McGlade, J. (2002). A high affinity Arg-X-X-Lys SH3-binding motif confers specificity for the interaction between Gads and SLP-76 in T-cell signaling. Current Biology 12: 1336-1341.
• Tong, J., Elowe, S., Nash, P., Pawson, T. (2003) Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAP kinase signaling and biological activity. Journal of Biological Chemistry 278: 6111-6119.
• Bladt, F., Aippersbach, E., Gelkop, S., Strasser, G. A., Nash, P., Tafuri, A., Gertler, F., Pawson, T. (2003) The murine Nck SH2/SH3 adaptors regulate mesoderm-derived embryonic structures in vivo and the cellular actin network. Molecular and Cellular Biology 23 (13): 4586-4597.
• Liu, Q., Nash, P., Berry, D., Pawson, T., McGlade, J., Li, S. (2003) Structural Basis for Specific Binding of the Gads SH3 domain to an RXXK Motif-containing Slp-76 Peptide: A Novel Mode of Peptide Recognition. Molecular Cell 11: 471-481.
• Leong, H., Sloan, J.R., Nash, P.D. and Greene, G.L. (2005) Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha. Molecular Endocrinology 19(12): 2930-42.
• Dai E, Viswanathan K, Sun YM, Li X, Liu L, Togonu-Bickersteth B, Richardson J, Macaulay C, Nash P, Turner P, Nazarian SH, Moyer R, McFadden G, Lucas AR. (2006) Identification of myxomaviral serpin reactive site loop sequences that regulate innate immune responses. Journal of Biological Chemistry 281(12):8041-50.
• Liu, B.A., Jablonowski, K., Raina, M., Arcé, M., Pawson, T., and Nash, P.D. (2006) The Human and Mouse Complement of SH2 Domain Proteins – establishing the boundaries of phosphotyrosine signaling. Molecular Cell 22: 851-868. http://www.molecule.org/content/article/abstract?uid=PIIS1097276506003741
• Zhang M, Veselits M, O'Neill S, Hou P, Reddi AL, Berlin I, Ikeda M, Nash PD, Longnecker R, Band H, Clark MR. (2007) Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor. Journal of Immunology
  Journal of Immunology
  The Journal of Immunology is a peer-reviewed academic journal that publishes basic and clinical studies in all aspects of immunology. It was founded by Arthur Fernandez Coca in 1915 . It is the official journal of The American Association of Immunologists and published by The American Association...
  
   179(7):4435-43.http://www.jimmunol.org/cgi/content/full/179/7/4435
• Machida K, Thompson CM, Dierck K, Jablonowski K, Kärkkäinen S, Liu B, Zhang H, Nash PD, Newman DK, Nollau P, Pawson T, Renkema GH, Saksela K, Schiller MR, Shin DG, Mayer BJ. (2007) High-throughput phosphotyrosine profiling using SH2 domains. Molecular Cell 26(6):899-915. http://www.molecule.org/content/article/abstract?uid=PIIS1097276507003346
• Sierra MI, Wright MH, Nash PD.(2010) AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. J. Biol Chem. 2010 Apr 30;285(18):13990-4004. http://www.jbc.org/content/285/18/13990.abstract
• Liu BA, Jablonowski K, Shah EE, Engelmann BW, Jones RB, Nash PD. (2010) SH2 domains recognize contextual peptide sequence information to determine selectivity. Molecular & Cellular Proteomics, 9, 2391-2404. http://www.mcponline.org/content/9/11/2391
• Berlin I, Schwartz H, Nash PD. (2010) Regulation of the epidermal growth factor receptor ubiquitination and trafficking by the USP8/STAM complex. J. Biol Chem. 285: 34909-34921. http://www.jbc.org/content/285/45/34909.abstract
• Berlin, I., Higginbotham, K.M. Dise, R.S. Sierra, M.I. and Nash, P.D. (2010) The Deubiquitinating Enzyme USP8 Promotes Trafficking and Degradation of the Chemokine Receptor at the Sorting Endosome. J. Biol. Chem. 285: 37895-37908. http://www.jbc.org/content/285/48/37895.abstract

Book Chapters

• Nash, P., Lucas, A., and McFadden, G. SERP-1, A Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection. "The SERPINS", Plenum Press, New York. Chapter 19: 195-205 (1997).
• Lalani, A., Nash, P., Seet, B., Robichaud, J. and McFadden, G. (1999) Interaction of DNA virus proteins with host cytokines. In DNA Viruses: A Practical Approach. Chapter 7, pages 177-208 Ed. A. Cann. Practical Approach Series. Oxford University Press.
• Zalai, C. V., Nash, P., Dai, E., Liu, L., Lucas, A. The Potential Role of Serine Proteinase Inhibitors for the Prevention of Plaque Rupture. Cardiovascular Plaque Rupture. DL Brown (editor), Marcel Dekker, Inc., New York, NY 1999.
• Pawson, T., and Nash, P. (2003) Modular protein interaction domains in cellular communication. Handbook of Cell Signaling. Volume 1. Chapter 67, pages 379-385.
• Pawson, T., Gish, G.D., and Nash, P. (2004) The SH2 domain: a prototype for protein interaction domains. In “Modular Protein Domains” ed. Cesareni, G. et al. Chapter 1, pages 5–36, Wiley VCH Press.
• Pawson, T., and Nash, P. (2009) Modular protein interaction domains in cellular communication. Handbook of Cell Signaling 2nd edition. Ralph Bradshaw & Edward Dennis (Editors). Volume 1. Chapter 57.

Review Articles

• Nash, P. D., Opas, M., and Michalak, M. (1994) Calreticulin: not just another calcium binding protein. Molecular and Cellular Biochemistry 135: 71-78.
• McFadden, G., Graham, K., Ellison, K., Barry, M., Macen, J., Schreiber, M., Mossman, K., Nash, P., Lalani, A., and Everett, H. (1995). Interruption of cytokine networks by poxviruses: lessons from myxoma virus. Journal of Leukocyte Biology 57: 731-738.
• McFadden, G., Lalani, A., Everett, H., Nash, P., and Xu, X. (1998) Virus-encoded receptors for cytokines and chemokines. Seminars in Cell and Developmental Biology 9: 359-368.
• Nash, P., Barrett, J., Cao, J., Hota-Mitchell, S., Lalani, A., Everett, H., Xu, X., Robichaud, J., Hnatiuk, S., Ainslie, C., Seet, B., and McFadden, G. (1999) Poxvirus immunomodulatory proteins are a window to the immune system: the myxoma virus story. Immunological Reviews 168: 103-120. http://www.blackwell-synergy.com/doi/abs/10.1111/j.1600-065X.1999.tb01286.x
• Xu, X., Nash, P., McFadden, G. (2000) Myxoma virus expresses a TNF receptor homolog with two distinct functions. Virus Genes 21 (1/2): 97-104.
• Pawson, T. and Nash, P. (2000) Protein-protein interactions define specificity in signal transduction. Genes & Development 14 (9): 1027–1047.
• Pawson, T., Gish, G., Nash, P. (2001). SH2 domains, interaction modules and cellular wiring. Trends in Cell Biology 11(12): 504-511.
• Pawson, T., Raina, M., Nash, P. (2002). Interaction domains: From simple binding events to complex cellular behaviour. FEBS Letters
  Federation of European Biochemical Societies
  The Federation of the European Biochemical Societies, frequently abbreviated FEBS is an international scientific society promoting activities in biochemistry, molecular biology and molecular biophysics in Europe...
  
   513: 2-10.
• Pawson, T. & Nash, P. (2003) Assembly of cell regulatory systems through protein interaction domains. Science
  Science (journal)
  Science is the academic journal of the American Association for the Advancement of Science and is one of the world's top scientific journals....
  
  300: 445-452. http://www.sciencemag.org/cgi/content/abstract/300/5618/445

This was the focus of the following review:
Gough, N.R., Adler, E.A., & Ray, L. B., Cellular Regulation through Protein Interaction Domains. An Editorial Guide appearing in Science magazine’s Signal Transduction Knowledge Environment (STKE) Vol. 2003, Issue 179, 22 April 2003.
Wright MH, Berlin I, Nash PD. (2010) Regulation of Endocytic Sorting by ESCRT-DUB-Mediated Deubiquitination. Cell Biochem Biophys. 60(1-2):39-46. http://www.ncbi.nlm.nih.gov/pubmed/21448666

Honors and awards

1992-1994 NSERC Graduate Fellowship

1992-1994 University of Alberta Walter Johns Award

1992-1997 AHFMR Graduate Fellowship

1996-1997 University of Alberta Walter Johns Award

1997-1998 University of Alberta Dissertation Scholarship

1999 NSERC Postdoctoral Fellowship (declined)

1999-2002 MRC/CIHR Postdoctoral Fellowship Award http://webapps.cihr-irsc.gc.ca/funding/detail_e?pResearchId=854490&p_version=CIHR&p_language=E&p_session_id=341818

2002 NCIC Postdoctoral Fellowship (declined)

2002-2004 CIHR Senior Research Fellowship http://webapps.cihr-irsc.gc.ca/funding/detail_e?pResearchId=860683&p_version=CIHR&p_language=E&p_session_id=341818

2005 Cancer Research Foundation Young Investigator Award http://www.cancerresearchfdn.org/newsletter/spring05/youth.shtml

2005-2006 Leukemia Research Foundation New Investigator Award

2006-2008 Jimmy V Foundation Scholar http://www.jimmyv.org/news.cfm?newsid=235

External links

• SH2 domain website (produced and maintained by the Nash Lab)
• The Ben May Institute for Cancer Research
• Molecular Biosciences at University of Chicago
• Publications noted on PubMed (NCBI)