A Pre-B cell is a precursor to the development of B cell

B cell

B cells are lymphocytes that play a large role in the humoral immune response . The principal functions of B cells are to make antibodies against antigens, perform the role of antigen-presenting cells and eventually develop into memory B cells after activation by antigen interaction...

s.

Certain leukemias/lymphomas are associated with immature B cell

B cell

B cells are lymphocytes that play a large role in the humoral immune response . The principal functions of B cells are to make antibodies against antigens, perform the role of antigen-presenting cells and eventually develop into memory B cells after activation by antigen interaction...

s, and observing pre-B cell populations can be useful in the identification of these conditions.

It expresses CD19

CD19

B-lymphocyte antigen CD19 also known as CD19 , is a protein that in humans is encoded by the CD19 gene.- Function :...

 and CD127

Interleukin-7 receptor

The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α and common-γ chain receptor . The common-γ chain receptors is shared with various...

, and the immunoglobulin heavy chain is rearranged, but the immunoglobulin light chain

Immunoglobulin light chain

]The immunoglobulin light chain is the small polypeptide subunit of an antibody .A typical antibody is composed of two immunoglobulin heavy chains and two Ig light chains.-In humans:...

is not yet rearranged at this stage.