Prostaglandin E synthase
Encyclopedia
Prostaglandin E synthase (or PGE synthase) is an enzyme
involved in eicosanoid
and glutathione
metabolism, a member of MAPEG family
. It generates prostaglandin E
(PGE) from prostaglandin H2
.
The synthase generating PGE2 is a membrane-associated protein.
s, each encoded by a separate gene:
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
involved in eicosanoid
Eicosanoid
In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, ....
and glutathione
Glutathione
Glutathione is a tripeptide that contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side-chain...
metabolism, a member of MAPEG family
MAPEG family
MAPEG family of transmembrane proteins with highly divergent functions...
. It generates prostaglandin E
Prostaglandin E
Prostaglandin E is a family of naturally occurring prostaglandins and may be used pharmaceutically in medicine.Types include:* Prostaglandin E1 also termed Alprostadil* Prostaglandin E2 also termed DinoprostoneIt is created from prostaglandin E synthase....
(PGE) from prostaglandin H2
Prostaglandin H2
Prostaglandin H2 is a type of Prostaglandin which is derived from arachidonic acid and is a precursor for many other biologically significant molecules.It is acted upon by:* prostacyclin synthase to create prostacyclin...
.
The synthase generating PGE2 is a membrane-associated protein.
Isozymes
Humans express three prostaglandin-E synthase isozymeIsozyme
Isozymes are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. These enzymes usually display different kinetic parameters Isozymes (also known as isoenzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. These enzymes...
s, each encoded by a separate gene: