Protein K is a human

Human

Humans are the only living species in the Homo genus...

 protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 found in the cell nucleus

Cell nucleus

In cell biology, the nucleus is a membrane-enclosed organelle found in eukaryotic cells. It contains most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. The genes within these...

 that binds to pre-messenger RNA

Messenger RNA

Messenger RNA is a molecule of RNA encoding a chemical "blueprint" for a protein product. mRNA is transcribed from a DNA template, and carries coding information to the sites of protein synthesis: the ribosomes. Here, the nucleic acid polymer is translated into a polymer of amino acids: a protein...

 (mRNA) as a component of heterogeneous ribonucleoprotein particle

Heterogeneous ribonucleoprotein particle

Heterogeneous nuclear ribonucleoproteins are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA . The presence of the proteins bound to a pre-mRNA molecule serves as a signal that the...

s. The simian

Simian

The simians are the "higher primates" familiar to most people: the Old World monkeys and apes, including humans, , and the New World monkeys or platyrrhines. Simians tend to be larger than the "lower primates" or prosimians.- Classification and evolution :The simians are split into three groups...

 homolog

Homology (biology)

Homology forms the basis of organization for comparative biology. In 1843, Richard Owen defined homology as "the same organ in different animals under every variety of form and function". Organs as different as a bat's wing, a seal's flipper, a cat's paw and a human hand have a common underlying...

 is known as protein H16. Both proteins bind to single-stranded DNA

DNA

Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...

 as well as to RNA

RNA

Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....

 and can stimulate the activity of RNA polymerase II

RNA polymerase II

RNA polymerase II is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase...

, the protein responsible for most gene transcription

Transcription (genetics)

Transcription is the process of creating a complementary RNA copy of a sequence of DNA. Both RNA and DNA are nucleic acids, which use base pairs of nucleotides as a complementary language that can be converted back and forth from DNA to RNA by the action of the correct enzymes...

. The relative affinities of the proteins for DNA and RNA vary with solution conditions and are inversely correlated, so that conditions promoting strong DNA binding result in weak RNA binding.

RNA binding protein domains in other proteins that are similar to the RNA binding domain of protein K are called K-homology or KH domains.

Protein K has been the subject of study related to colorectal cancer

Colorectal cancer

Colorectal cancer, commonly known as bowel cancer, is a cancer caused by uncontrolled cell growth , in the colon, rectum, or vermiform appendix. Colorectal cancer is clinically distinct from anal cancer, which affects the anus....

, in which an RNA editing

RNA editing

The term RNA editing describes those molecular processes in which the information content in an RNA molecule is altered through a chemical change in the base makeup. To date, such changes have been observed in tRNA, rRNA, mRNA and microRNA molecules of eukaryotes but not prokaryotes...

 event inducing the expression

Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as ribosomal RNA , transfer RNA or small nuclear RNA genes, the product is a functional RNA...

 of an isoform containing a point mutation

Point mutation

A point mutation, or single base substitution, is a type of mutation that causes the replacement of a single base nucleotide with another nucleotide of the genetic material, DNA or RNA. Often the term point mutation also includes insertions or deletions of a single base pair...

 was found to be specific to cancerous cells.

Human proteins containing KH domain

AKAP1

AKAP1

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.-Interactions:AKAP1 has been shown to interact with MYCBP, C3orf15, PRKAR1A, PRKAR2A and PRKAR1B.-Further reading:...

; ANKHD1

ANKHD1

Ankyrin repeat and KH domain-containing protein 1 is a protein that in humans is encoded by the ANKHD1 gene.-Further reading:...

; ANKRD17

ANKRD17

Ankyrin repeat domain-containing protein 17 is a protein that in humans is encoded by the ANKRD17 gene.-Further reading:...

; ASCC1; BICC1; DDX43

DDX43

Probable ATP-dependent RNA helicase DDX43 is an enzyme that in humans is encoded by the DDX43 gene.-Further reading:...

; DDX53; DPPA5;
FMR1

FMR1

FMR1 is a human gene that codes for a protein called fragile X mental retardation protein, or FMRP. This protein, most commonly found in the brain, is essential for normal cognitive development and female reproductive function...

; FUBP1; FUBP3; FXR1

FXR1

Fragile X mental retardation syndrome-related protein 1 is a protein that in humans is encoded by the FXR1 gene.-Interactions:FXR1 has been shown to interact with FXR2 and FMR1.-Further reading:...

; FXR2

FXR2

Fragile X mental retardation syndrome-related protein 2 is a protein that in humans is encoded by the FXR2 gene.-Interactions:FXR2 has been shown to interact with FXR1, LCMT1, FMR1 and CYFIP1.-Further reading:...

; HDLBP

HDLBP

Vigilin is a protein that in humans is encoded by the HDLBP gene.-Further reading:...

; HNRPK

HNRPK

Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene.-Interactions:HNRPK has been shown to interact with KHDRBS1, PCBP2, PTBP1, DDX1, PRMT1, HNRNPL and C-src tyrosine kinase.-Further reading:...

; IGF2BP1

IGF2BP1

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.-Further reading:...

;
IGF2BP2

IGF2BP2

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.-Further reading:...

; IGF2BP3

IGF2BP3

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.-Further reading:...

; KHDRBS1

KHDRBS1

KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene.-Further reading:...

; KHDRBS2; KHDRBS3

KHDRBS3

KH domain-containing, RNA-binding, signal transduction-associated protein 3 is a protein that in humans is encoded by the KHDRBS3 gene.-Further reading:...

; KHSRP

KHSRP

Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene.-Further reading:...

; KRR1

KRR1

KRR1 small subunit processome component homolog is a protein that in humans is encoded by the KRR1 gene.-Further reading:...

; MEX3A;
MEX3B

MEX3B

RNA-binding protein MEX3B is a protein that in humans is encoded by the MEX3B gene.-Further reading:...

; MEX3C; MEX3D

MEX3D

Mex-3 homolog D , also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.- Function :MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2...

; NOVA1

NOVA1

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.-Further reading:...

; NOVA2; PCBP1

PCBP1

Poly-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.-Further reading:...

; PCBP2

PCBP2

Poly-binding protein 2 is a protein that in humans is encoded by the PCBP2 gene.In humans, the PCBP2 gene overlaps with TUC338, a transcribed ultra-conserved element implicated in Hepatocellular carcinoma.-Interactions:...

; PCBP3

PCBP3

Poly-binding protein 3 is a protein that in humans is encoded by the PCBP3 gene.-Further reading:...

;
PCBP4

PCBP4

Poly-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.-Further reading:...

; PNO1

PNO1

RNA-binding protein PNO1 is a protein that in humans is encoded by the PNO1 gene.-Further reading:...

; PNPT1; QKI

QKI

Quaking homolog, KH domain RNA binding , also known as QKI, is a protein which in humans is encoded by the QKI gene.QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA. They have an HNRNPK homology domain embedded in a 200-amino acid...

; SF1

SF1 (gene)

Splicing factor 1 also known as zinc finger protein 162 is a protein that in humans is encoded by the SF1 gene.Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.-Interactions:...

; TDRKH

TDRKH

Tudor and KH domain-containing protein is a protein that in humans is encoded by the TDRKH gene.-Further reading:...

;