Protein subfamily
Encyclopedia
Protein subfamily is a level of protein classification, especially protein 3D structures. It is under protein family. Protein family
Protein family
A protein family is a group of evolutionarily-related proteins, and is often nearly synonymous with gene family. The term protein family should not be confused with family as it is used in taxonomy....

 in SCOP
SCOP
SCOP may refer to:* Structural Classification of Proteins* Suprachiasmatic nucleus circadian oscillatory protein, a member of the leucine-rich repeat protein family* Société coopérative, a type of corporation in France...

(Structural Classification of Proteins) means the members are all related evolutionarily and they share very similar structures with functional similarities. Protein subfamily is when the family members share the same interaction interfaces and interaction partners. This more strict criterion forces that all the subfamily members have to share functionally related.

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