RIP-Chip is immunoprecipitation

Immunoprecipitation

Immunoprecipitation is the technique of precipitating a protein antigen out of solution using an antibody that specifically binds to that particular protein. This process can be used to isolate and concentrate a particular protein from a sample containing many thousands of different proteins...

 of an RNA-binding protein coupled to reverse transcription and a microarray

DNA microarray

A DNA microarray is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome...

. It has been used to find interactions between RNA

RNA

Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....

 and protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 (one protein but many RNA species per analysis).

A similar technique is ChIP-on-chip

ChIP-on-chip

ChIP-on-chip is a technique that combines chromatin immunoprecipitation with microarray technology . Like regular ChIP, ChIP-on-chip is used to investigate interactions between proteins and DNA in vivo...

, which detects the binding of proteins to genomic DNA rather than RNA. A competing technique is CLIP-Seq

CLIP-Seq

CLIP-Seq, also called HITS-CLIP, is a method in molecular biology, used for finding which RNA species interact with a particular RNA-binding protein...

 (also called RIP-Seq), where high-throughput sequencing replaces the microarray.