RNA-binding protein
Encyclopedia
RNA-binding proteins are proteins that bind to RNA
. They bind to either double-strand or single-strand RNA
s through RNA
recognition motif (RRM). RNA-binding proteins (often abbreviated as RBP) may regulate the translation of RNA
, and post-transcriptional events, such as RNA
splicing, editing.
They are cytoplasm
ic and nuclear
proteins. However, since most mature RNA is exported from the nucleus relatively quickly, most RBPs in the nucleus exist as complexes of protein and pre-mRNA
called heterogeneous ribonucleoprotein particles
(hnRNPs).
s, ADAR
, etc.
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
. They bind to either double-strand or single-strand RNA
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
s through RNA
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
recognition motif (RRM). RNA-binding proteins (often abbreviated as RBP) may regulate the translation of RNA
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
, and post-transcriptional events, such as RNA
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
splicing, editing.
They are cytoplasm
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
ic and nuclear
Cell nucleus
In cell biology, the nucleus is a membrane-enclosed organelle found in eukaryotic cells. It contains most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. The genes within these...
proteins. However, since most mature RNA is exported from the nucleus relatively quickly, most RBPs in the nucleus exist as complexes of protein and pre-mRNA
Precursor mRNA
Precursor mRNA is an immature single strand of messenger ribonucleic acid . pre-mRNA is synthesized from a DNA template in the cell nucleus by transcription. Pre-mRNA comprises the bulk of heterogeneous nuclear RNA...
called heterogeneous ribonucleoprotein particles
Heterogeneous ribonucleoprotein particle
Heterogeneous nuclear ribonucleoproteins are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA . The presence of the proteins bound to a pre-mRNA molecule serves as a signal that the...
(hnRNPs).
Examples
Some examples include: translation initiation factors that bind RNA, polyA-binding proteins, snRNPSnRNP
snRNPs , or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs...
s, ADAR
ADAR
Double-stranded RNA-specific adenosine deaminase is an enzyme that in humans is encoded by the ADAR gene.-Further reading:...
, etc.
External links
- starBase database: a database for decoding binding sites of RNA binding proteins (RBPs) from CLIP-SeqCLIP-SeqCLIP-Seq, also called HITS-CLIP, is a method in molecular biology, used for finding which RNA species interact with a particular RNA-binding protein...
(HITS-CLIP, PAR-CLIP, iCLIP) data. - RBPDB database: a database of RNA binding proteins.