ROCK1
Encyclopedia
Rho-associated, coiled-coil containing protein kinase 1, also known as ROCK1, is a protein serine/threonine kinase, but also denotes the human gene
encoding it.
It is activated when bound to the GTP-bound form of Rho GTPase
. This protein is thus a downstream effector of Rho. It phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin
, inhibiting its actin-depolymerizing activity. Thus, ROCK1 contributes to actin
-stability.
with PFN2
and RHOA
.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
encoding it.
It is activated when bound to the GTP-bound form of Rho GTPase
Rho GTPase
A Rho GTPase may refer to:*Any member of the Rho family of GTPases*The members of the Rho family of GTPases belonging to the Rho subclass*RhoA, the most-studied member of the Rho subclass of the Rho family of GTPases...
. This protein is thus a downstream effector of Rho. It phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin
Cofilin
ADF/cofilin is a family of actin-binding proteins which disassembles actin filaments.Three highly conserved and highly identical genes belonging to this family have been described in human and mice:...
, inhibiting its actin-depolymerizing activity. Thus, ROCK1 contributes to actin
Actin
Actin is a globular, roughly 42-kDa moonlighting protein found in all eukaryotic cells where it may be present at concentrations of over 100 μM. It is also one of the most highly-conserved proteins, differing by no more than 20% in species as diverse as algae and humans...
-stability.
Interactions
ROCK1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with PFN2
PFN2
Profilin-2 is a protein that in humans is encoded by the PFN2 gene.-Interactions:PFN2 has been shown to interact with ROCK1, Vasodilator-stimulated phosphoprotein and FMNL1.-Further reading:...
and RHOA
RHOA
Ras homolog gene family, member A is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. In humans, it is encoded by the gene RHOA....
.
External links
- ROCK1 Info with links in the Cell Migration Gateway