Rev-ErbA
Encyclopedia
The Rev-ErbA proteins are members of the nuclear receptor
family of intracellular
transcription factor
s. There are two forms of the receptor, alpha
and beta
, each encoded by a separate gene ( and respectively).
The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor
(TR) gene.
The rev-Erb-α protein is a key regulatory component of the circadian clock. In addition, rev-Erb-α appears also to regulate the breakdown of cartilage
.
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...
family of intracellular
Intracellular
Not to be confused with intercellular, meaning "between cells".In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".It is used in contrast to extracellular...
transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s. There are two forms of the receptor, alpha
Rev-ErbA alpha
Rev-ErbA alpha also known as NR1D1 , is a protein that in humans is encoded by the NR1D1 gene.Rev-erbα is member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor...
and beta
Rev-ErbA beta
Rev-ErbA beta also known as NR1D2 is a protein that in humans is encoded by the NR1D2 gene.Rev-erbβ is a member of the Rev-ErbA family of transcription factors...
, each encoded by a separate gene ( and respectively).
The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor
Thyroid hormone receptor
The thyroid hormone receptor is a type of nuclear receptor that is activated by binding thyroid hormone.-Function:Amongst the most important functions of thyroid hormone receptors are regulation of metabolism and heart rate...
(TR) gene.
The rev-Erb-α protein is a key regulatory component of the circadian clock. In addition, rev-Erb-α appears also to regulate the breakdown of cartilage
Cartilage
Cartilage is a flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs...
.