Rs7997012
Encyclopedia
In genetics
, rs7997012 is a gene variation—a single nucleotide polymorphism
(SNP)—in intron
2 of the human HTR2A gene
that codes for the 5-HT2A receptor
.
The SNP varies between adenine
(A) and guanine
(G) DNA bases with the G-allele being most frequent.
A research study found it to be related to antidepressant
treatment.
The research group reported that a polymorphism (rs1954787
) on another gene, the GRIK4
, has also shown a treatment-response-association in this kind of treatment.
In a Japanese study rs7997012 was not associated with neither major depressive disorder nor bipolar disorder
.
Rs6311
, rs6313
and His452Tyr (rs6314) are other SNPs in the HTR2A gene.
There are many more, even in intron 2 alone.
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....
, rs7997012 is a gene variation—a single nucleotide polymorphism
Single nucleotide polymorphism
A single-nucleotide polymorphism is a DNA sequence variation occurring when a single nucleotide — A, T, C or G — in the genome differs between members of a biological species or paired chromosomes in an individual...
(SNP)—in intron
Intron
An intron is any nucleotide sequence within a gene that is removed by RNA splicing to generate the final mature RNA product of a gene. The term intron refers to both the DNA sequence within a gene, and the corresponding sequence in RNA transcripts. Sequences that are joined together in the final...
2 of the human HTR2A gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
that codes for the 5-HT2A receptor
5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor . This is the main excitatory receptor subtype among the GPCRs for serotonin , although 5-HT2A may also have an inhibitory effect on certain areas such...
.
The SNP varies between adenine
Adenine
Adenine is a nucleobase with a variety of roles in biochemistry including cellular respiration, in the form of both the energy-rich adenosine triphosphate and the cofactors nicotinamide adenine dinucleotide and flavin adenine dinucleotide , and protein synthesis, as a chemical component of DNA...
(A) and guanine
Guanine
Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine . In DNA, guanine is paired with cytosine. With the formula C5H5N5O, guanine is a derivative of purine, consisting of a fused pyrimidine-imidazole ring system with...
(G) DNA bases with the G-allele being most frequent.
A research study found it to be related to antidepressant
Antidepressant
An antidepressant is a psychiatric medication used to alleviate mood disorders, such as major depression and dysthymia and anxiety disorders such as social anxiety disorder. According to Gelder, Mayou &*Geddes people with a depressive illness will experience a therapeutic effect to their mood;...
treatment.
The research group reported that a polymorphism (rs1954787
Rs1954787
Rs1954787 is a gene variation, a single nucleotide polymorphism in the GRIK4 gene.A study has reported that this polymorphism is associated with success of antidepressant treatment....
) on another gene, the GRIK4
GRIK4
GRIK4 is a kainate receptor subtype belonging to the family of ligand-gated ion channels which is encoded by the gene.-Function:...
, has also shown a treatment-response-association in this kind of treatment.
In a Japanese study rs7997012 was not associated with neither major depressive disorder nor bipolar disorder
Bipolar disorder
Bipolar disorder or bipolar affective disorder, historically known as manic–depressive disorder, is a psychiatric diagnosis that describes a category of mood disorders defined by the presence of one or more episodes of abnormally elevated energy levels, cognition, and mood with or without one or...
.
Rs6311
Rs6311
In genetics rs6311 is a gene variation—a single nucleotide polymorphism —in the human HTR2A gene that codes for the 5-HT2A receptor. 5-HT2A is neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with...
, rs6313
Rs6313
In genetics, rs6313 also called T102C or C102T is a gene variation—a single nucleotide polymorphism —in the human HTR2A gene that codes for the 5-HT2A receptor....
and His452Tyr (rs6314) are other SNPs in the HTR2A gene.
There are many more, even in intron 2 alone.