Septin-9 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the SEPT9 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Interactions

SEPT9 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with SEPT2

SEPT2

Septin 2, also known as SEPT2, is a protein which in humans is encoded by the SEPT2 gene.- Function :SEPT2 can hetero-oligomerize with SEPT6 and SEPT7 to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. Knockdown of SEPT2, SEPT6, and SEPT7 in causes actin...

 and SEPT7

SEPT7

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.-Interactions:SEPT7 has been shown to interact with SEPT2 and SEPT9.-Further reading:...

.

Biology

Along with AHNAK

AHNAK

Neuroblast differentiation-associated protein AHNAK is a protein that in humans is encoded by the AHNAK gene.-Further reading:...

, eIF4E

EIF4E

Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein which in humans is encoded by the eIF4E gene.- Function :...

 and S100A11

S100A11

Protein S100-A11 is a protein that in humans is encoded by the S100A11 gene.-Interactions:S100A11 has been shown to interact with Nucleolin and S100B.-Further reading:...

, SEPT9 has been shown to be essential for pseudopod protrusion, tumor cell migration and invasion.

Clinical Significance

The v2 region of the SEPT9 promoter has been shown to be methylated in colorectal cancer

Colorectal cancer

Colorectal cancer, commonly known as bowel cancer, is a cancer caused by uncontrolled cell growth , in the colon, rectum, or vermiform appendix. Colorectal cancer is clinically distinct from anal cancer, which affects the anus....

tissue compared with normal colonic mucosa. Using highly sensitive real time PCR assays, methylated SEPT9 was detected in the blood of colorectal cancer patients.

Further reading