SEPT2
Encyclopedia
Septin 2, also known as SEPT2, is a protein
which in humans is encoded by the SEPT2 gene
.
and SEPT7
to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. Knockdown
of SEPT2, SEPT6, and SEPT7 in causes actin
stress fibers to disintegrate and cells to lose polarity
. Septins, SOCS7
, and NCK1
are part of a signaling pathway that couples regulation of the DNA damage response to the cytoskeleton.
with SEPT9
, SEPT6
and SEPT7
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which in humans is encoded by the SEPT2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
SEPT2 can hetero-oligomerize with SEPT6SEPT6
Septin-6 is a protein that in humans is encoded by the SEPT6 gene.-Further reading:...
and SEPT7
SEPT7
Septin-7 is a protein that in humans is encoded by the SEPT7 gene.-Interactions:SEPT7 has been shown to interact with SEPT2 and SEPT9.-Further reading:...
to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. Knockdown
Gene knockdown
Gene knockdown refers to techniques by which the expression of one or more of an organism's genes is reduced, either through genetic modification or by treatment with a reagent such as a short DNA or RNA oligonucleotide with a sequence complementary to either an mRNA transcript or a gene...
of SEPT2, SEPT6, and SEPT7 in causes actin
Actin
Actin is a globular, roughly 42-kDa moonlighting protein found in all eukaryotic cells where it may be present at concentrations of over 100 μM. It is also one of the most highly-conserved proteins, differing by no more than 20% in species as diverse as algae and humans...
stress fibers to disintegrate and cells to lose polarity
Cell polarity
Cell Polarity refers to spatial differences in the shape, structure, and function of cells. Almost all cell types exhibit some sort of polarity, which enables them to carry out specialized functions...
. Septins, SOCS7
SOCS7
Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.-Further reading:...
, and NCK1
NCK1
Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.-Interactions:NCK1 has been shown to interact with DNM1, EIF2B2, KHDRBS1, Lymphocyte cytosolic protein 2, EPH receptor B1, SOCS7, MINK1, MAP4K1, MAP4K4, Abl gene, WIPF1, RRAS, Wiskott-Aldrich syndrome protein,...
are part of a signaling pathway that couples regulation of the DNA damage response to the cytoskeleton.
Interactions
SEPT2 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with SEPT9
SEPT9
Septin-9 is a protein that in humans is encoded by the SEPT9 gene.-Interactions:SEPT9 has been shown to interact with SEPT2 and SEPT7.-Biology:...
, SEPT6
SEPT6
Septin-6 is a protein that in humans is encoded by the SEPT6 gene.-Further reading:...
and SEPT7
SEPT7
Septin-7 is a protein that in humans is encoded by the SEPT7 gene.-Interactions:SEPT7 has been shown to interact with SEPT2 and SEPT9.-Further reading:...
.