SMG1 (gene)
Encyclopedia
Serine/threonine-protein kinase SMG1 is an enzyme
that in humans is encoded by the SMG1 gene
. SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase
protein family.
with PRKCI
and UPF1
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the SMG1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase
Phosphatidylinositol 3-kinase-related kinase
Phosphatidylinositol 3-kinase-related kinases are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases .- Members :The human PIKK family includes six members:- Structure :...
protein family.
Interactions
SMG1 (gene) has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with PRKCI
PRKCI
Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.-Interactions:PRKCI has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase, Centaurin, alpha 1, Phosphoinositide-dependent kinase-1, FRS2, SMG1 , Sequestosome 1 and PARD3.-Further reading:...
and UPF1
UPF1
Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the UPF1 gene.-Interactions:UPF1 has been shown to interact with UPF2, SMG1, DCP2, DCP1A, UPF3A and UPF3B.-Further reading:...
.