SMN1
Encyclopedia
Survival motor neuron protein is a protein
that in humans is encoded by the SMN1 gene
.
with Gem-associated protein 7
, GEMIN4
, KPNB1
, Survival of motor neuron protein-interacting protein 1
, DDX20
, Coilin
, Small nuclear ribonucleoprotein D1
, Fibrillarin
, HNRNPR
, GEMIN5
, Nucleolar protein, member A1, Bcl-2
, Small nuclear ribonucleoprotein D2
, Far upstream element-binding protein 1
, P53
and DHX9
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SMN1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
SMN1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Gem-associated protein 7
Gem-associated protein 7
Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.-Interactions:Gem-associated protein 7 has been shown to interact with SMN1 and Gem-associated protein 6.-Further reading:...
, GEMIN4
GEMIN4
Component of gems 4 is a protein that in humans is encoded by the GEMIN4 gene.-Interactions:GEMIN4 has been shown to interact with DDX20, EIF2C2, LGALS1 and SMN1.-Further reading:...
, KPNB1
KPNB1
Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.-Interactions:KPNB1 has been shown to interact with NUP98, Karyopherin alpha 1, KPNA3, Karyopherin alpha 2, SMN1, Parathyroid hormone-related protein, Nucleoporin 62, RANBP2, Ran , RANBP1, NUP50, P53, NUP153 and...
, Survival of motor neuron protein-interacting protein 1
Survival of motor neuron protein-interacting protein 1
Survival of motor neuron protein-interacting protein 1 is a protein that in humans is encoded by the SIP1 gene.-Interactions:Survival of motor neuron protein-interacting protein 1 has been shown to interact with DDX20 and SMN1.-Further reading:...
, DDX20
DDX20
Probable ATP-dependent RNA helicase DDX20 is an enzyme that in humans is encoded by the DDX20 gene.-Interactions:DDX20 has been shown to interact with LSM2, Small nuclear ribonucleoprotein polypeptide F, SNRPG, GEMIN4, Survival of motor neuron protein-interacting protein 1, SMN1, Small nuclear...
, Coilin
Coilin
Coilin is a protein that in humans is encoded by the COIL gene.Coilin protein is one of the main molecular components of Cajal bodies . Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small...
, Small nuclear ribonucleoprotein D1
Small nuclear ribonucleoprotein D1
Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.-Interactions:Small nuclear ribonucleoprotein D1 has been shown to interact with DDX20, CLNS1A, CDC5L, Small nuclear ribonucleoprotein D2 and SMN1....
, Fibrillarin
Fibrillarin
Fibrillarin is a component of several ribonucleoproteins including a nucleolar small nuclear ribonucleoprotein and one of the two classes of small nucleolar ribonucleoproteins . SnRNAs function in RNA splicing while snoRNPs function in ribosomal RNA processing.Fibrillarin is associated with U3, U8...
, HNRNPR
HNRNPR
Heterogeneous nuclear ribonucleoprotein R is a protein that in humans is encoded by the HNRNPR gene.-Interactions:HNRNPR has been shown to interact with SMN1 and PRMT1.-Further reading:...
, GEMIN5
GEMIN5
Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.-Interactions:GEMIN5 has been shown to interact with DDX20 and SMN1.-Further reading:...
, Nucleolar protein, member A1, Bcl-2
Bcl-2
Bcl-2 is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in...
, Small nuclear ribonucleoprotein D2
Small nuclear ribonucleoprotein D2
Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene.-Interactions:Small nuclear ribonucleoprotein D2 has been shown to interact with DDX20, Small nuclear ribonucleoprotein D1, Small nuclear ribonucleoprotein polypeptide F, CDC5L and SMN1.-Further reading:...
, Far upstream element-binding protein 1
Far upstream element-binding protein 1
Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.-Interactions:Far upstream element-binding protein 1 has been shown to interact with MAPK14 and SMN1.-Further reading:...
, P53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
and DHX9
DHX9
ATP-dependent RNA helicase A is an enzyme that in humans is encoded by the DHX9 gene.-Interactions:...
.
External Links
- http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sma GeneReviews/NCBI/NIH/UW entry on Spinal Muscular Atrophy including Arthrogryposis Multiplex Congenita-Spinal Muscular Atrophy (AMC-SMA); Spinal Muscular Atrophy I (Werdnig-Hoffmann Disease, SMA1); Spinal Muscular Atrophy II (SMA II); Spinal Muscular Atrophy III (Kugelberg-Welander Disease, SMA III); Spinal Muscular Atrophy IV (SMA IV)]