Saizen
Encyclopedia
Saizen is a commercial preparation of synthetic somatropin (growth hormone
, a.k.a. GH). Manufactured by Merck Serono
, Saizen is produced by recombinant DNA
technology from a mammal
ian cell line (mouse C127) that was modified by the addition of the human GH gene
, resulting in an identical 191-amino acid
sequence and structure.
Saizen is injected. It is intended for long-term treatment of youngsters whose growth failure is due to inadequate production of growth hormone. However, as with other forms of HGH, it is subject to other usage, such as for bodybuilding
and athletic performance enhancement. More recently, Saizen has been used in IVF protocols by a few physicians for female patients undergoing infertility
treatment in an attempt to increase the number and quality of oocytes retrieved.
It affects:
Saizen usage should be performed under the regular guidance of a physician who is experienced in the diagnosis and management of growth disorders.
Children with inadequate secretion of growth hormone sometimes experience fasting hypoglycemia
that is improved by treatment with growth hormone. Using Saizen may decrease glucose
tolerance. Because human growth hormone may induce a state of insulin
resistance, patients should be observed for evidence of glucose intolerance. As with human growth hormone, Saizen should be used with caution in patients with diabetes mellitus
or a family history of diabetes mellitus.
(Human chorionic gonadotropin) and pass it off as Generic HGH, and since testing the HGH chemical substance is a very expensive process, the bootleggers know that most, if not all, of their customers wouldn’t even attempt to test them.
HCG (Human chorionic gonadotropin) powder is visually identical to HGH lyophilic powder, and must be reconstituted the same way using bacteriostatic or sterile water. If overused, HCG can be a very dangerous substance. About 42% of North American black market HGH confiscated are fakes.
The majority of fake HGH can be identified by colored top (mostly blue top) vials, with printed ink that can be easily wiped off from the label. The text on the labels is usually in the Spanish language. Another way to test your vial is to rigorously shake it. The actual manufacturers of HGH (rDNA) such as Merck-EMD Serono
and Eli Lilly and Company
, strongly state in their pamphlets, that their reconstituted vials can easily become cloudy if shaken too rigorously. The reason is that HGH is a protein
and Serono and Eli Lilly warn against injecting the cloudy substance. So if your vial does not become cloudy or stays cloudy after a violent shake, then you know you’ve been scammed.
Growth hormone
Growth hormone is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans and other animals. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior...
, a.k.a. GH). Manufactured by Merck Serono
Merck Serono
Merck Serono is a pharmaceutical company headquartered in Geneva, Switzerland. In September 2006, Merck KGaA announced its intent to purchase the majority of Serono shares from Ernesto Bertarelli and the Bertarelli family. The Merck-Serono merger was announced on September 21, 2006...
, Saizen is produced by recombinant DNA
Recombinant DNA
Recombinant DNA molecules are DNA sequences that result from the use of laboratory methods to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in biological organisms...
technology from a mammal
Mammal
Mammals are members of a class of air-breathing vertebrate animals characterised by the possession of endothermy, hair, three middle ear bones, and mammary glands functional in mothers with young...
ian cell line (mouse C127) that was modified by the addition of the human GH gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
, resulting in an identical 191-amino acid
Amino acid
Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...
sequence and structure.
Usage
Saizen is injected. It is intended for long-term treatment of youngsters whose growth failure is due to inadequate production of growth hormone. However, as with other forms of HGH, it is subject to other usage, such as for bodybuilding
Bodybuilding
Bodybuilding is a form of body modification involving intensive muscle hypertrophy. An individual who engages in this activity is referred to as a bodybuilder. In competitive and professional bodybuilding, bodybuilders display their physiques to a panel of judges, who assign points based on their...
and athletic performance enhancement. More recently, Saizen has been used in IVF protocols by a few physicians for female patients undergoing infertility
Infertility
Infertility primarily refers to the biological inability of a person to contribute to conception. Infertility may also refer to the state of a woman who is unable to carry a pregnancy to full term...
treatment in an attempt to increase the number and quality of oocytes retrieved.
It affects:
- Tissue growth
- Skeletal growth
- Cell growth (especially muscle growth)
- Organ growth
- Metabolism
- Protein metabolism
- Carbohydrate metabolism
- Lipid metabolism
- Mineral metabolism
- Connective tissue and bone metabolism
Saizen usage should be performed under the regular guidance of a physician who is experienced in the diagnosis and management of growth disorders.
Children with inadequate secretion of growth hormone sometimes experience fasting hypoglycemia
Hypoglycemia
Hypoglycemia or hypoglycæmia is the medical term for a state produced by a lower than normal level of blood glucose. The term literally means "under-sweet blood"...
that is improved by treatment with growth hormone. Using Saizen may decrease glucose
Glucose
Glucose is a simple sugar and an important carbohydrate in biology. Cells use it as the primary source of energy and a metabolic intermediate...
tolerance. Because human growth hormone may induce a state of insulin
Insulin
Insulin is a hormone central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle....
resistance, patients should be observed for evidence of glucose intolerance. As with human growth hormone, Saizen should be used with caution in patients with diabetes mellitus
Diabetes mellitus
Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced...
or a family history of diabetes mellitus.
Warnings: Black-Market HGH
Those seeking HGH (Human Growth Hormone) therapy without a prescription from licensed physicians must be aware that there are several fake HGH manufacturers floating around the web. Most of these manufacturers actually use a substance called hCGHuman chorionic gonadotropin
Human chorionic gonadotropin or human chorionic gonadotrophin is a glycoprotein hormone produced during pregnancy that is made by the developing embryo after conception and later by the syncytiotrophoblast .. Some tumors make this hormone; measured elevated levels when the patient is not...
(Human chorionic gonadotropin) and pass it off as Generic HGH, and since testing the HGH chemical substance is a very expensive process, the bootleggers know that most, if not all, of their customers wouldn’t even attempt to test them.
HCG (Human chorionic gonadotropin) powder is visually identical to HGH lyophilic powder, and must be reconstituted the same way using bacteriostatic or sterile water. If overused, HCG can be a very dangerous substance. About 42% of North American black market HGH confiscated are fakes.
The majority of fake HGH can be identified by colored top (mostly blue top) vials, with printed ink that can be easily wiped off from the label. The text on the labels is usually in the Spanish language. Another way to test your vial is to rigorously shake it. The actual manufacturers of HGH (rDNA) such as Merck-EMD Serono
Serono
Serono is a biotechnology company headquartered in Geneva, Switzerland. The company was founded as the Serono Pharmacolodgical Institute by Cesare Serono in 1906 in Italy. A key step in its development was the discovery of a method of extracting urinary gonadotropins by Dr Piero Donini allowing...
and Eli Lilly and Company
Eli Lilly and Company
Eli Lilly and Company is a global pharmaceutical company. Eli Lilly's global headquarters is located in Indianapolis, Indiana, in the United States...
, strongly state in their pamphlets, that their reconstituted vials can easily become cloudy if shaken too rigorously. The reason is that HGH is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
and Serono and Eli Lilly warn against injecting the cloudy substance. So if your vial does not become cloudy or stays cloudy after a violent shake, then you know you’ve been scammed.