Santiago Schnell
Encyclopedia
Santiago Schnell is a member of mathematical biology
and systems biology
community working the field of biochemistry and cellular physiology. He is Associate Professor of Molecular & Integrative Physiology, a U-M Brehm Investigator in the Brehm Center for Type 1 Diabetes Research & Analysis, and a Research Associate Professor of Computational Medicine & Bioinformatics at the University of Michigan
. His methods for modeling reactions inside cells are one of the fast moving frontiers in the field of computer science according to the Institute for Scientific Information.
Dr. Schnell is member of the Board of Directors of the Society for Mathematical Biology
. He serves on the Editorial Boards of Mathematical Biosciences, Computational Biology & Chemistry, Computational and Mathematical Methods in Medicine and IET Systems Biology.
in Venezuela and doctorate in mathematical biology from the University of Oxford
, England, United Kingdom.
.
(USA), Investigación y Ciencia (Spain and Latin-America), Spektrum der Wissenschaft (Germany).
Mathematical biology
Mathematical and theoretical biology is an interdisciplinary scientific research field with a range of applications in biology, medicine and biotechnology...
and systems biology
Systems biology
Systems biology is a term used to describe a number of trends in bioscience research, and a movement which draws on those trends. Proponents describe systems biology as a biology-based inter-disciplinary study field that focuses on complex interactions in biological systems, claiming that it uses...
community working the field of biochemistry and cellular physiology. He is Associate Professor of Molecular & Integrative Physiology, a U-M Brehm Investigator in the Brehm Center for Type 1 Diabetes Research & Analysis, and a Research Associate Professor of Computational Medicine & Bioinformatics at the University of Michigan
University of Michigan
The University of Michigan is a public research university located in Ann Arbor, Michigan in the United States. It is the state's oldest university and the flagship campus of the University of Michigan...
. His methods for modeling reactions inside cells are one of the fast moving frontiers in the field of computer science according to the Institute for Scientific Information.
Dr. Schnell is member of the Board of Directors of the Society for Mathematical Biology
Society for Mathematical Biology
The Society for Mathematical Biology is an international association co-founded in 1972 in USA by Drs.George Karreman, Herbert Daniel Landahl and by Anthony Bartholomay for the furtherance of joint scientific activities between Mathematics and Biology research communities,...
. He serves on the Editorial Boards of Mathematical Biosciences, Computational Biology & Chemistry, Computational and Mathematical Methods in Medicine and IET Systems Biology.
Education
Dr. Schnell received his initial training in biological science from Universidad Simón BolívarUniversidad Simón Bolívar
Simón Bolívar University or USB, is a public institution located in Miranda State, Venezuela with scientific and technological orientation....
in Venezuela and doctorate in mathematical biology from the University of Oxford
University of Oxford
The University of Oxford is a university located in Oxford, United Kingdom. It is the second-oldest surviving university in the world and the oldest in the English-speaking world. Although its exact date of foundation is unclear, there is evidence of teaching as far back as 1096...
, England, United Kingdom.
Professional Work
From 2001-2004, he was Junior Research Fellow at Christ Church (a college of the University of Oxford) and a Research Fellow of the Welcome Trust at the Center for Mathematical Biology in the University of Oxford. He was Assistant Professor of Informatics and Associate Director of the Biocomplexity Institute at Indiana University, Bloomington between 2004-2008. Currently he is an Associate Professor of Molecular & Integrative Physiology, a U-M Brehm Investigator in the Brehm Center for Diabetes Research, and a Research Associate Professor of Computational Medicine & Bioinformatics at the University of MichiganUniversity of Michigan
The University of Michigan is a public research university located in Ann Arbor, Michigan in the United States. It is the state's oldest university and the flagship campus of the University of Michigan...
.
Research
His research has focused on developing methods for modeling reactions inside cells, and how to quantify and model enzyme reactions and metabolic pathways. Dr. Schnell has also extensive experience in developing multiscale models of developmental processes and colorectal cancer. His work has been highlighted in popular science magazines, such as American ScientistAmerican Scientist
American Scientist is the bimonthly science and technology magazine published since 1913 by Sigma Xi. Each issue includes four to five feature articles written by scientists and engineers. These authors review research in all fields of science...
(USA), Investigación y Ciencia (Spain and Latin-America), Spektrum der Wissenschaft (Germany).
Teaching and Outreach
Dr. Schnell received the Faculty Award for Teaching Excellence from the School of Informatics at Indiana University in 2006. As a member the Hispanic community, Dr. Schnell is actively promoting involvement of Hispanic and other minorities in science. He is life member of the Society for the Advancement of Hispanics/Chicanos and Native Americans in Science.Publications
He has published over 60 articles in academic journals, edited several special issues and a book. These scholarly publications includes:- S. Schnell and C. Mendoza (1997). A closed-form solution for time-dependent enzyme kinetic. Journal of theoretical Biology 187, 207-212. DOI: 10.1006/jtbi.1997.0425
- S. Schnell and P. K. Maini (2000). Enzyme kinetics at high enzyme concentration. Bulletin of Mathematical Biology 62, 483-499. DOI: 10.1006/bulm.1999.0163
- S. Schnell, P. K. Maini, D. McInerney, D. J. Gavaghan and P. Houston (2002). Pattern formation models for somitogenesis: a marriage of cellular and molecular biology. Comptes Rendus Biologies 325, 179-189. DOI: 10.1016/S1631-0691(01)01418-4
- S. Schnell and P. K. Maini (2003). A century of enzyme kinetics: Reliability of the KM and vmax estimates. Comments on Theoretical Biology 8, 169-187. DOI: 10.1080/08948550390206768
- S. Schnell and T. E. Turner (2004). Reaction kinetics in intracellular environments with macromolecular crowding: simulations and rate laws. Progress in Biophysics and Molecular Biology 85, 235-260. DOI: 10.1016/j.pbiomolbio.2004.01.012
- E. J. Crampin, S. Schnell and P. McSharry (2004). Mathematical and computational techniques to deduce complex biochemical reaction mechanisms. Progress in Biophysics and Molecular Biology 86, 77-112. DOI: 10.1016/j.pbiomolbio.2004.04.002
- T. E. Turner, S. Schnell and K. Burrage (2004). Stochastic approaches for modelling in vivo reactions. Computational Biology and Chemistry 28, 165-178. (review) DOI: 10.1016/j.compbiolchem.2004.05.001
- B. Ribba, T. Collin and S. Schnell (2006). A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies. Theoretical Biology and Medical Modelling 3, 7. DOI: 10.1186/1742-4682-3-7
- E. H. Flach and S. Schnell (2006). On the use and abuse of the Quasi-Steady-State Approximation. IEE Proceedings Systems Biology 153, 187-191. DOI: 10.1049/ip-syb:20050104
- R. Grima and S. Schnell (2006). A systematic investigation of the rate laws valid in intracellular environments. Biophysical Chemistry 124, 1-10. DOI: 0.1016/j.bpc.2006.04.019
- S. Schnell, R. Grima and P. K. Maini (2007). Multiscale modeling in biology. American Scientist 95, 134-142. DOI: 10.1511/2007.64.1018
- S. Schnell, R. Grima and P. K. Maini (2007). Modelización en biología a través de escalas múltiples. Investigación y Ciencia, Mayo 2007, Número 268, pp. 60–69.
- S. Schnell, P. K. Maini, S. Newman, T. J. Newman (editors) (2008). Multiscale modeling of developmental systems. Series: Current Topics in Developmental Biology. Volume 81. New York: Academic Press. (ISBN 978 0 12 374283 7)