Siplizumab
Encyclopedia
Siplizumab is a novel monoclonal antibody with a human IgG1, kappa directed to CD2
. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T
and NK cells, and is currently being tested as a possible treatment for psoriasis
and in the prevention of graft-versus-host disease
.
CD2
CD2 is a cell adhesion molecule found on the surface of T cells and natural killer cells.It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor....
. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T
T cell
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells , by the presence of a T cell receptor on the cell surface. They are...
and NK cells, and is currently being tested as a possible treatment for psoriasis
Psoriasis
Psoriasis is an autoimmune disease that appears on the skin. It occurs when the immune system mistakes the skin cells as a pathogen, and sends out faulty signals that speed up the growth cycle of skin cells. Psoriasis is not contagious. However, psoriasis has been linked to an increased risk of...
and in the prevention of graft-versus-host disease
Graft-versus-host disease
Graft-versus-host disease is a common complication after a stem cell transplant or bone marrow transplant from another person . Immune cells in the donated marrow or stem cells recognize the recipient as "foreign". The transplanted immune cells then attack the host's body cells...
.