Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3

Sodium-hydrogen antiporter 3

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 or solute carrier family 9 member 3 is a protein that in humans is encoded by the SLC9A3 gene....

. It is encoded by the gene SLC9A3R1. It is also known as ERM

ERM

ERM may refer to: In systems and processes:* European Exchange Rate Mechanism* European Reference Materials* Enterprise relationship management* Enterprise risk management* Entity-relationship model...

 Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed to interact via long-range allostery, involving significant protein dynamics.

Mechanism

Members of the ezrin (VIL2; MIM 123900)-radixin (RDX; MIM 179410)-moesin (MSN; MIM 309845) (ERM) protein family are highly concentrated in the apical aspect of polarized epithelial cells. These cells are studded with microvilli containing bundles of actin filaments, which must attach to the membrane to assemble and maintain the microvilli. The ERM proteins, together with merlin, the NF2 (MIM 607379) gene product, are thought to be linkers between integral membrane and cytoskeletal proteins, and they bind directly to actin in vitro. Actin cytoskeleton reorganization requires the activation of a sodium/hydrogen exchanger (SLC9A3; MIM 182307). SLC9A3R1 is an ERM-binding protein.[supplied by OMIM]

Interactions

Sodium-hydrogen antiporter 3 regulator 1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Beta-catenin

Beta-catenin

Beta-catenin is a protein that in humans is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo...

, GNAQ

GNAQ

Guanine nucleotide-binding protein G subunit alpha is a protein that in humans is encoded by the GNAQ gene.-Interactions:GNAQ has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1, RIC8A, RGS16, Beta adrenergic receptor kinase, RGS4 and Bruton's tyrosine kinase.-Further reading:...

, Kappa Opioid receptor

Kappa Opioid receptor

The κ-opioid receptor is a protein that in humans is encoded by the OPRK1 gene. The κ-opioid receptor is one of five related receptors that bind opium-like compounds in the brain and are responsible for mediating the effects of these compounds...

, SLC4A8

SLC4A8

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.-Interactions:SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1 and Cystic fibrosis transmembrane conductance regulator.-Further reading:...

, Beta-2 adrenergic receptor

Beta-2 adrenergic receptor

The beta-2 adrenergic receptor , also known as ADRB2, is a beta-adrenergic receptor, and also denotes the human gene encoding it.-Gene:The gene is intronless...

, PDZK1

PDZK1

Na/H exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.-Interactions:PDZK1 has been shown to interact with AKAP10, FARP2, Sodium-hydrogen antiporter 3 regulator 1, SLC22A12, SLK, SLC22A4, CLCN3, PDZK1IP1, Cystic fibrosis transmembrane conductance...

, YAP1

YAP1

65 kDa Yes-associated protein is a protein that in humans is encoded by the YAP1 gene.-Interactions:YAP1 has been shown to interact with Mothers against decapentaplegic homolog 7, ERBB4, Sodium-hydrogen antiporter 3 regulator 1, TP53BP2 and P73....

, Cystic fibrosis transmembrane conductance regulator

Cystic fibrosis transmembrane conductance regulator

Cystic fibrosis transmembrane conductance regulator is a protein that in humans is encoded by the CFTR gene.CFTR is a ABC transporter-class ion channel that transports chloride and thiocyanate ions across epithelial cell membranes...

, PAG1

PAG1

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.-Interactions:...

, PDGFRB

PDGFRB

Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.-Interactions:PDGFRB has been shown to interact with PTPN11, NCK1, Grb2, Caveolin 1, PDGFRA, Sodium-hydrogen antiporter 3 regulator 1, RAS p21 protein activator 1, CRK, SHC1 and...

, Parathyroid hormone receptor 1

Parathyroid hormone receptor 1

Parathyroid hormone/parathyroid hormone-related peptide receptor also known as parathyroid hormone 1 receptor is a protein that in humans is encoded by the PTH1R gene...

, EZR and PDGFRA

PDGFRA

Alpha-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRA gene.-Interactions:PDGFRA has been shown to interact with PDGFRB, PLCG1, Sodium-hydrogen antiporter 3 regulator 1, Cbl gene, CRK, Caveolin 1 and PDGFC.-Further reading:...

.

See also

• CFTR
  CFTR
  CFTR is:*Cystic fibrosis transmembrane conductance regulator, a protein involved in the transport of chloride ions across cell membranes or the gene that encodes this protein*CFTR inhibitory factor, a protein virulence factor...
  
  
• Ezrin
• Moesin
  Moesin
  Moesin is a protein that in humans is encoded by the MSN gene.Moesin is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons...
  
  
• Neutron spin echo
  Neutron spin echo
  Neutron spin echo spectroscopy is an inelastic neutron scattering technique invented by Ferenc Mezei in the 1970's, and developed in collaboration with John Hayter.In recognition of his work and in other areas, Mezei was awarded the first in 1999....
  
  
• Radixin
  Radixin
  Radixin is a protein that in humans is encoded by the RDX gene.Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to...
  
  
• Solute carrier family
  Solute carrier family
  The solute carrier group of membrane transport proteins include over 300 members organized into 51 families. The SLC gene nomenclature system was originally proposed by the Human Genome Organization and is the basis for the official HUGO names of the genes that encode these transporters...
  
  

Further reading