Solute carrier family
Encyclopedia
The solute carrier group of membrane transport proteins include over 300 members organized into 51 families. The SLC gene nomenclature system was originally proposed by the Human Genome Organization (HUGO
) and is the basis for the official HUGO names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB database.
Solutes
that are transported by the various SLC group members are extraordinarily diverse and include both charged and uncharged organic molecules as well as inorganic ions and the gas ammonia
.
As is typical of integral membrane protein
s, SLCs contain a number of hydrophobic transmembrane alpha helices
connected to each other by hydrophilic intra- and extra-cellular loops. Depending on the SLC, these transporters are functional as either monomers or obligate homo- or hetero-oligomers.
system, members within an individual SLC family have greater than 20-25% sequence homology to each other. In contrast, the homology between SLC families is very low to non-existent. Hence, the criteria for inclusion of a family into the SLC group is not evolutionary relatedness to other SLC families but rather functional (i.e., an integral membrane protein that transports a solute).
The SLC group include examples of transport proteins that are:
The SLC series does not include members of transport protein families that have previously been classified by other widely accepted nomenclature systems including:
, but some members are located in mitochondria (the most notable one being SLC family 25) or other intracellular
organelle
s.
where:
For example is the first isoform of subfamily A of SLC family 1.
An exception occurs with SLC family 21 (the organic anion transporting polypeptide transporters), which for historical reasons have names in the format SLCOnXm where n = family number, X = subfamily letter, and m = member number.
While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lowercase letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene).
Human Genome Project
The Human Genome Project is an international scientific research project with a primary goal of determining the sequence of chemical base pairs which make up DNA, and of identifying and mapping the approximately 20,000–25,000 genes of the human genome from both a physical and functional...
) and is the basis for the official HUGO names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB database.
Solutes
Solution
In chemistry, a solution is a homogeneous mixture composed of only one phase. In such a mixture, a solute is dissolved in another substance, known as a solvent. The solvent does the dissolving.- Types of solutions :...
that are transported by the various SLC group members are extraordinarily diverse and include both charged and uncharged organic molecules as well as inorganic ions and the gas ammonia
Ammonia transporter
Ammonia transporters are structurally related membrane transport proteins called Amt proteins , methylammonium/ammonium permeases or RhAG, RhBG, and RhCG Rh family members in mammals. The RhAG, RhBG and RhCG proteins constitute solute carrier family 42...
.
As is typical of integral membrane protein
Integral membrane protein
An integral membrane protein is a protein molecule that is permanently attached to the biological membrane. Proteins that cross the membrane are surrounded by "annular" lipids, which are defined as lipids that are in direct contact with a membrane protein...
s, SLCs contain a number of hydrophobic transmembrane alpha helices
Alpha helix
A common motif in the secondary structure of proteins, the alpha helix is a right-handed coiled or spiral conformation, in which every backbone N-H group donates a hydrogen bond to the backbone C=O group of the amino acid four residues earlier...
connected to each other by hydrophilic intra- and extra-cellular loops. Depending on the SLC, these transporters are functional as either monomers or obligate homo- or hetero-oligomers.
Scope
By convention of the nomenclatureGene nomenclature
Gene nomenclature is the scientific naming of genes, the units of heredity in living organisms. An international committee published recommendations for genetic symbols and nomenclature in 1957. The need to develop formal guidelines for human gene names and symbols was recognized in the 1960s and...
system, members within an individual SLC family have greater than 20-25% sequence homology to each other. In contrast, the homology between SLC families is very low to non-existent. Hence, the criteria for inclusion of a family into the SLC group is not evolutionary relatedness to other SLC families but rather functional (i.e., an integral membrane protein that transports a solute).
The SLC group include examples of transport proteins that are:
- facilitative transporters (allow solutes to flow downhill with their electrochemical gradientsMembrane potentialMembrane potential is the difference in electrical potential between the interior and exterior of a biological cell. All animal cells are surrounded by a plasma membrane composed of a lipid bilayer with a variety of types of proteins embedded in it...
) - secondary active transportSecondary active transportIn secondary active transport or co-transport, uses energy to transport molecules across a membrane; however, in contrast to primary active transport, there is no direct coupling of ATP; instead, the electrochemical potential difference created by pumping ions out of the cell is used...
ers (allow solutes to flow uphill against their electrochemical gradient by coupling to transport of a second solute that flows downhill with its gradient such that the overall free energy change is still favorable)
The SLC series does not include members of transport protein families that have previously been classified by other widely accepted nomenclature systems including:
- primary active transportPrimary active transportPrimary active transport, also called direct active transport, directly uses energy to transport molecules across a membrane.Most of the enzymes that perform this type of active transport are transmembrane ATPases. A primary ATPase universal to all cellular life is the sodium-potassium pump, which...
ers (allow flow uphill against electrochemical gradients) such as ABC (ATPAdenosine triphosphateAdenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...
Binding Cassette) transporters by coupling transport to an energy releasing event such as ATP hydrolysis - ion channelIon channelIon channels are pore-forming proteins that help establish and control the small voltage gradient across the plasma membrane of cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells...
s - aquaporinAquaporinAquaporins are proteins embedded in the cell membrane that regulate the flow of water.Aquaporins are integral membrane proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells....
s (water channels)
Subcellular distribution
Most members of the SLC group are located in the cell membraneCell membrane
The cell membrane or plasma membrane is a biological membrane that separates the interior of all cells from the outside environment. The cell membrane is selectively permeable to ions and organic molecules and controls the movement of substances in and out of cells. It basically protects the cell...
, but some members are located in mitochondria (the most notable one being SLC family 25) or other intracellular
Intracellular
Not to be confused with intercellular, meaning "between cells".In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".It is used in contrast to extracellular...
organelle
Organelle
In cell biology, an organelle is a specialized subunit within a cell that has a specific function, and is usually separately enclosed within its own lipid bilayer....
s.
Nomenclature system
Names of individual SLC members have the following format:- SLCnXm
where:
- SLC is the root name (SoLute Carrier)
- n = an integer representing a family (e.g., 1-47)
- X = a single letter (A, B, C, ...) denoting a subfamily
- m = an integer representing an individual family member (isoformProtein isoformA protein isoform is any of several different forms of the same protein. Different forms of a protein may be produced from related genes, or may arise from the same gene by alternative splicing. A large number of isoforms are caused by single-nucleotide polymorphisms or SNPs, small genetic...
).
For example is the first isoform of subfamily A of SLC family 1.
An exception occurs with SLC family 21 (the organic anion transporting polypeptide transporters), which for historical reasons have names in the format SLCOnXm where n = family number, X = subfamily letter, and m = member number.
While the HUGO nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lowercase letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene).
Families
- (1) high-affinity glutamate and neutral amino acid transporterGlutamate transporterExcitatory amino-acid transporters , formerly known as Glutamate transporters, belong to the family of neurotransmitter transporters. They serve to terminate the excitatory neurotransmitter signal by removal of glutamate from the neuronal synapse into Glia cells.In details, the EAATs are...
- (SLC1A1SLC1A1Excitatory amino-acid transporter 3 is a protein that in humans is encoded by the SLC1A1 gene.-Further reading:...
, SLC1A2SLC1A2Excitatory amino-acid transporter 2 also known as solute carrier family 1 member 2 is a protein that in humans is encoded by the SLC1A2 gene...
, SLC1A3Glutamate aspartate transporterSolute carrier family 1 , member 3, also known as SLC1A3,is a protein that, in humans, is encoded by the SLC1A3 gene...
, SLC1A4SLC1A4Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.In melanocytic cells SLC1A4 gene expression may be regulated by MITF.-Further reading:...
, SLC1A5SLC1A5Neutral amino acid transporter B is a protein that in humans is encoded by the SLC1A5 gene.-Further reading:...
, SLC1A6Excitatory amino acid transporter 4Excitatory amino-acid transporter 4 is a protein that in humans is encoded by the SLC1A6 gene.EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride...
, SLC1A7Excitatory amino acid transporter 5Excitatory amino-acid transporter 5 is a protein that in humans is encoded by the SLC1A7 gene.EAAT4 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.-Further reading:...
)
- (SLC1A1
- (2) facilitative GLUT transporter
- (SLC2A1GLUT1Glucose transporter 1 , also known as solute carrier family 2, facilitated glucose transporter member 1 is a protein that in humans is encoded by the SLC2A1 gene...
, SLC2A2GLUT2Glucose transporter 2 also known as solute carrier family 2 , member 2 is a transmembrane carrier protein that enables passive glucose movement across cell membranes. It is the principal transporter for transfer of glucose between liver and blood, and for renal glucose reabsorption...
, SLC2A3GLUT3Glucose transporter 3 , also known as solute carrier family 2, facilitated glucose transporter member 3 is a protein that in humans is encoded by the SLC2A3 gene. GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells...
, SLC2A4GLUT4Glucose transporter type 4, also known as GLUT4, is a protein that in humans is encoded by the GLUT4 gene. GLUT4 is the insulin-regulated glucose transporter found in adipose tissues and striated muscle that is responsible for insulin-regulated glucose translocation into the cell...
, SLC2A5GLUT4Glucose transporter type 4, also known as GLUT4, is a protein that in humans is encoded by the GLUT4 gene. GLUT4 is the insulin-regulated glucose transporter found in adipose tissues and striated muscle that is responsible for insulin-regulated glucose translocation into the cell...
, SLC2A6SLC2A6Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.-Further reading:...
, SLC2A7SLC2A7Solute carrier family 2, facilitated glucose transporter member 7 also known as glucose transporter 7 is a protein that in humans is encoded by the SLC2A7 gene....
, SLC2A8GLUT8GLUT8 also known as SLC2A8 is the eighth member of glucose transporter superfamily.It is characterized by the presence of two leucine residues in its N-terminal intracellular domain, which influences intracellular trafficking.- Discovery :...
, SLC2A9SLC2A9Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia and...
, SLC2A10SLC2A10Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene.-See also:* Glucose transporter* Solute carrier family* Arterial tortuosity syndrome-Further reading:...
, SLC2A11SLC2A11Solute carrier family 2, facilitated glucose transporter member 11 also known as glucose transporter type 10/11 is a protein that in humans is encoded by the SLC2A11 gene....
, SLC2A12SLC2A12Solute carrier family 2, facilitated glucose transporter member 12 is a protein that in humans is encoded by the SLC2A12 gene.-Further reading:...
, SLC2A13SLC2A13Solute carrier family 2 , member 13 is a protein that in humans is encoded by the SLC2A13 gene.-Further reading :...
, SLC2A14SLC2A14Solute carrier family 2 , member 14 is a protein that in humans is encoded by the SLC2A14 gene.Members of the glucose transporter family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells...
)
- (SLC2A1
- (3) heavy subunits of heterodimeric amino acid transporterHeterodimeric amino acid transporterHeterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membranes. Each transporter comprises a two-protein, a light and heavy, subunit....
s- (SLC3A1SLC3A1SLC3A1 is a protein associated with cystinuria.Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene.-Further reading:...
, SLC3A2SLC3A24F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 gene.SLC3A2 comprises the light subunit of the large neutral amino acid transporter that is also known as CD98 .- Function :SLC3A2 is a member of the solute carrier family and encodes a cell surface,...
)
- (SLC3A1
- (4) bicarbonate transporter
- (SLC4A1Band 3Anion Exchanger 1 or Band 3 is a phylogenetically preserved transport protein responsible for mediating the exchange of chloride for bicarbonate across a plasma membrane. Functionally similar members of the AE clade are AE2 and AE3.It is ubiquitous throughout the vertebrates...
, SLC4A2SLC4A2Anion exchange protein 2 is a membrane transport protein that in humans is encoded by the SLC4A2 gene. AE2 is functionally similar to the Band 3 Cl-/HCO3- exchange protein....
, SLC4A3SLC4A3Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl-/HCO3- exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have...
, SLC4A4SLC4A4Electrogenic sodium bicarbonate cotransporter 1 is a membrane transport protein that in humans is encoded by the SLC4A4 gene.-Splice Variants:NBCe1-A aka kNBC1...
, SLC4A5SLC4A5Electrogenic sodium bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene.-Further reading:...
, SLC4A6, SLC4A7SLC4A7Solute carrier family 4, sodium bicarbonate cotransporter, member 7, also known as SLC4A7, is a human gene.-Further reading:...
, SLC4A8SLC4A8Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.-Interactions:SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1 and Cystic fibrosis transmembrane conductance regulator.-Further reading:...
, SLC4A9, SLC4A10, SLC4A11SLC4A11Sodium bicarbonate transporter-like protein 11 is a protein that in humans is encoded by the SLC4A11 gene.-Further reading:...
)
- (SLC4A1
- (5) sodium glucose cotransporterSodium-glucose transport proteinsSodium-dependent glucose cotransporters are a family of glucose transporter found in the intestinal mucosa of the small intestine and the proximal tubule of the nephron . They contribute to renal glucose reabsorption...
- (SLC5A1SLC5A1Sodium/glucose cotransporter 1 is a protein that in humans is encoded by the SLC5A1 gene.- Cloning of the sodium-glucose cotransporter SGLT1 :...
, SLC5A2SLC5A2The sodium/glucose cotransporter 2 is a protein that in humans is encoded by the SLC5A2 gene.- Function :...
, SLC5A3SLC5A3Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.Expression of the myo-inositol transport protein is regulated by osmotic stress.-Further reading:...
, SLC5A4SLC5A4The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 or solute carrier family 5 member 4 is a protein that in humans is encoded by the SLC5A4 gene....
, SLC5A5Sodium-iodide symporterThe sodium/iodide symporter , also known as solute carrier family 5, member 5 is a protein that in humans is encoded by the SLC5A5 gene. The sodium/iodide symporter is a transmembrane glycoprotein with a molecular weight of 87 kDa and 13 transmembrane domains, which transports two sodium cations ...
, SLC5A6SLC5A6Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.-Further reading:...
, SLC5A7, SLC5A8SLC5A8Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.-Further reading:...
, SLC5A9, SLC5A10, SLC5A11, SLC5A12)
- (SLC5A1
- (6) sodiumSodiumSodium is a chemical element with the symbol Na and atomic number 11. It is a soft, silvery-white, highly reactive metal and is a member of the alkali metals; its only stable isotope is 23Na. It is an abundant element that exists in numerous minerals, most commonly as sodium chloride...
- and chlorideChlorideThe chloride ion is formed when the element chlorine, a halogen, picks up one electron to form an anion Cl−. The salts of hydrochloric acid HCl contain chloride ions and can also be called chlorides. The chloride ion, and its salts such as sodium chloride, are very soluble in water...
-dependent sodium:neurotransmitter symporters- (SLC6A1SLC6A1GABA transporter 1 also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.- Function :...
, SLC6A2Norepinephrine transporterThe norepinephrine transporter , also known as solute carrier family 6 member 2 , is a protein that in humans is encoded by the SLC6A2 gene....
, SLC6A3Dopamine transporterThe dopamine transporter is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synapse back into cytosol, from which other transporters sequester DA and NE into vesicles for later storage and release...
, SLC6A4Serotonin transporterThe serotonin transporter is a monoamine transporter protein.This protein is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it...
, SLC6A5SLC6A5Glycine transporter 2 also known as the sodium- and chloride-dependent glycine transporter 2 or solute carrier family 6 member 5 is a protein that in humans is encoded by the SLC6A5 gene....
, SLC6A6SLC6A6Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.-Further reading:...
, SLC6A7, SLC6A8SLC6A8Sodium- and chloride-dependent creatine transporter 1 is a protein that in humans is encoded by the SLC6A8 gene.-External links:*-Further reading:...
, SLC6A9SLC6A9Sodium- and chloride-dependent glycine transporter 1 is a protein that in humans is encoded by the SLC6A9 gene.-Selective inhibitors:Elevation of extracellular synaptic glycine concentration by blockade of GlyT1 has been hypothesized to potentiate NMDA receptor function in vivo and to represent a...
, SLC6A10, SLC6A11, SLC6A12, SLC6A13, SLC6A14SLC6A14Sodium- and chloride-dependent neutral and basic amino acid transporter B is a protein that in humans is encoded by the SLC6A14 gene.-Further reading:...
, SLC6A15SLC6A15Solute carrier family 6 member 15 also known as the sodium-dependent neutral amino acid transporter BAT2 ' is a protein that in humans is encoded by the SLC6A15 gene.- Function :...
, SLC6A16, SLC6A17, SLC6A18SLC6A18Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.- Function :...
, SLC6A19SLC6A19Solute carrier family 6 member 19 also known as the sodium-dependent neutral amino acid transporter BAT1 or system B neutral amino acid transporter AT1 is a protein that in humans is encoded by the SLC6A19 gene.- Function :...
, SLC6A20SLC6A20Solute carrier family 6, member 20 also known as SLC6A20 is a protein which in humans is encoded by the SLC6A20 gene.- Function :...
)
- (SLC6A1
- (7) cationic amino acid transporter/glycoprotein-associated
- cationic amino acid transporters (SLC7A1SLC7A1High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene.-Further reading:...
, SLC7A2SLC7A2Low affinity cationic amino acid transporter 2 is a protein that in humans is encoded by the SLC7A2 gene.-Further reading:...
, SLC7A3SLC7A3Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.-Further reading:...
, SLC7A4SLC7A4Cationic amino acid transporter 4 is a protein that in humans is encoded by the SLC7A4 gene.-Further reading:...
) - glycoprotein-associated/light or catalytic subunits of heterodimeric amino acid transporterHeterodimeric amino acid transporterHeterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membranes. Each transporter comprises a two-protein, a light and heavy, subunit....
s (SLC7A5CD98CD98 is a glycoprotein that is a heterodimer composed of SLC3A2 and SLC7A5 that forms the large neutral amino acid transporter . LAT1 is a heterodimeric membrane transport protein that preferentially transports branched-chain and aromatic amino acids...
, SLC7A6SLC7A6Solute carrier family 7 member 6 also known as cationic amino acid transporter, y+ system or Y+L amino acid transporter 2 is a protein that in humans is encoded by the SLC7A6 gene.-Further reading:...
, SLC7A7SLC7A7Y+L amino acid transporter 1 is a protein that in humans is encoded by the SLC7A7 gene.-See also:* Heterodimeric amino acid transporter* Solute carrier family* Lysinuric protein intolerance-Further reading:-External links:*...
, SLC7A8SLC7A8Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.-Further reading:...
, SLC7A9SLC7A9Solute carrier family 7 , member 9 also known as SLC7A9 is a protein which in humans is encoded by the SLC7A9 gene.- Function :...
, SLC7A10SLC7A10Solute carrier family 7 member 10 also known as Asc-type amino acid transporter 1 or Asc-1 is a protein that in humans is encoded by the SLC7A10 gene....
, SLC7A11SLC7A11Cystine/glutamate transporter is a protein that in humans is encoded by the SLC7A11 gene.-Further reading:...
, SLC7A13, SLC7A14)
- cationic amino acid transporters (SLC7A1
- (8) Na+/Ca2+ exchanger
- (SLC8A1, SLC8A2, SLC8A3)
- (9) Na+/H+ exchanger
- (SLC9A1, SLC9A2SLC9A2Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.-Further reading:...
, SLC9A3, SLC9A4, SLC9A5SLC9A5Sodium–hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.-Further reading:...
, SLC9A6SLC9A6Sodium/hydrogen exchanger 6 is a protein that in humans is encoded by the SLC9A6 gene.-Further reading:...
, SLC9A7, SLC9A8SLC9A8Sodium/hydrogen exchanger 8 is a protein that in humans is encoded by the SLC9A8 gene.-Further reading:...
, SLC9A9, SLC9A10SLC9A10Sodium/hydrogen exchanger 10, also known as solute carrier family 9 member 10, is a protein that in humans is encoded by the SLC9A10 gene.- Function :...
, SLC9A11SLC9A11Sodium/hydrogen exchanger 11, also known as solute carrier family 9, member 11, is a protein that in humans is encoded by the SLC9A11 gene. SLC9A11 is a member of the sodium-hydrogen exchanger family....
)
- (SLC9A1, SLC9A2
- (10) sodium bile salt cotransport
- (SLC10A1SLC10A1Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide or liver bile acid transporter is a protein that in humans is encoded by the SLC10A1 gene....
, SLC10A2SLC10A2Ileal sodium/bile acid cotransporter also known as ileal sodium-dependent bile acid transporter is a protein that in humans is encoded by the SLC10A2 gene.-Further reading:...
, SLC10A3SLC10A3P3 protein is a protein that in humans is encoded by the SLC10A3 gene.-Further reading:...
, SLC10A4, SLC10A5, SLC10A6, SLC10A7SLC10A7Solute carrier family 10 , member 7, also known as SLC10A7, is a protein which in humans is encoded by the SLC10A7 gene.-Further reading:...
)
- (SLC10A1
- (11) proton coupled metal ion transporter
- (SLC11A1SLC11A1Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.-Further reading:...
, SLC11A2)
- (SLC11A1
- (12) electroneutral cation-Cl cotransporter
- (SLC12A1, SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6SLC12A6Solute carrier family 12 member 6 is a protein that in humans is encoded by the SLC12A6 gene.-External links:*-Further reading:...
, SLC12A7SLC12A7Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.-Further reading:...
, SLC12A8SLC12A8Solute carrier family 12 member 8 , also known as cation-chloride cotransporter 9 , is a protein that in humans is encoded by the SLC12A8 gene....
, SLC12A9SLC12A9Solute carrier family 12 member 9 , also known as cation-chloride cotransporter 6 or cation-chloride cotransporter-interacting protein 1 , is a protein that in humans is encoded by the SLC12A9 gene....
)
- (SLC12A1, SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6
- (13) human Na+-sulfate/carboxylate cotransporter
- (SLC13A1, SLC13A2SLC13A2Solute carrier family 13 member 2 is a protein that in humans is encoded by the SLC13A2 gene.-Further reading:...
, SLC13A3SLC13A3Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter is a protein that in humans is encoded by the SLC13A3 gene.-Further reading:...
, SLC13A4, SLC13A5)
- (SLC13A1, SLC13A2
- (14) urea transporterUrea transporterAn urea transporter is a membrane transport protein, transporting urea. Humans and other mammals have two types of urea transport proteins, UT-A and UT-B. The UT-A proteins are important for renal urea handling and are produced by alternative splicing of the SLC14A2 gene...
- (SLC14A1SLC14A1Urea transporter, erythrocyte is a protein that in humans is encoded by the SLC14A1 gene.-Function:The SLC14A1 codes for a urea transporter that is expressed in erythrocytes and kidney. SLC14A2 and SLC14A1 constitute solute carrier family 14. UTB proteins constitute the Kidd antigen...
, SLC14A2SLC14A2Urea transporter, kidney also known as urea transporter 2 or solute carrier family 14 member 2 is a protein that in humans is encoded by the SLC14A2 gene.- Function :...
)
- (SLC14A1
- (15) proton oligopeptide cotransporter
- (SLC15A1, SLC15A2SLC15A2Solute carrier family 15 , member 2, also known as SLC15A2, is a human gene.-Further reading:...
, SLC15A3, SLC15A4)
- (SLC15A1, SLC15A2
- (16) monocarboxylate transporter
- (SLC16A1SLC16A1Monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC16A1 gene.-Further reading:...
, SLC16A2SLC16A2Monocarboxylate transporter 8 is a protein that in humans is encoded by the SLC16A2 gene.- Function :MCT8 transports a variety of iodo-thyronines including the thyroid hormones T3 and T4.- Clinical significance :...
, SLC16A3SLC16A3Monocarboxylate transporter 4 is a protein that in humans is encoded by the SLC16A3 gene.-Further reading:...
, SLC16A4SLC16A4Monocarboxylate transporter 5 is a protein that in humans is encoded by the SLC16A4 gene.-Further reading:...
, SLC16A5, SLC16A6, SLC16A7, SLC16A8, SLC16A9SLC16A9The solute carrier family 16, member 9 also known as the monocarboxylate transporter 9 is a protein that in humans is encoded by the SLC16A9 gene.- Clinical relevance :...
, SLC16A10SLC16A10Monocarboxylate transporter 10 , also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 and solute carrier family 16 member 10 , is a protein that in humans is encoded by the SLC16A10 gene...
, SLC16A11, SLC16A12, SLC16A13, SLC16A14)
- (SLC16A1
- (17) vesicular glutamate transporter
- (SLC17A1SLC17A1Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.-Further reading:...
, SLC17A2, SLC17A3, SLC17A4, SLC17A5SLC17A5Solute carrier family 17 , member 5, also known as SLC17A5 or sialin, is a protein which in humans is encoded by the SLC17A5 gene.-Further reading:...
, SLC17A6, SLC17A7SLC17A7Vesicular glutamate transporter 1 is a protein that in humans is encoded by the SLC17A7 gene.-Further reading:...
, SLC17A8SLC17A8Solute carrier family 17 member 8 also known as the vesicular glutamate transporter 3 is a protein that in humans is encoded by the SLC17A8 gene.- Function :This gene encodes a vesicular glutamate transporter...
, SLC17A9)
- (SLC17A1
- (18) vesicular amine transporter
- (SLC18A1VMAT1VMAT1 is a protein that transports the monoamines into intracellular vesicles.In chromaffin cells, it is responsible for transporting newly synthesized epinephrine from the cytosol back into chromaffin granules in preparation for release.For norepinephrine to be acted upon by PNMT in the cytosol,...
, SLC18A2VMAT2The vesicular monoamine transporter 2 also known as solute carrier family 18 member 2 is a protein that in humans is encoded by the SLC18A2 gene...
, SLC18A3Vesicular acetylcholine transporterThe Vesicular acetylcholine transporter is a neurotransmitter transporter which is responsible for loading acetylcholine into secretory organelles in neurons making acetylcholine available for secretion.-Radiolabeled compounds:...
)
- (SLC18A1
- (19) folate/thiamineThiamineThiamine or thiamin or vitamin B1 , named as the "thio-vitamine" is a water-soluble vitamin of the B complex. First named aneurin for the detrimental neurological effects if not present in the diet, it was eventually assigned the generic descriptor name vitamin B1. Its phosphate derivatives are...
transporter- (SLC19A1SLC19A1Solute carrier family 19 , member 1, also known as SLC19A1 or RFC1, is a protein which in humans is encoded by the SLC19A1 gene.- Function :...
, SLC19A2SLC19A2Thiamine transporter 1, also known as thiamine carrier 1 or solute carrier family 19 member 2 is a protein that in humans is encoded by the SLC19A2 gene...
, SLC19A3SLC19A3Thiamine transporter 2 , also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene...
)
- (SLC19A1
- (20) type III Na+-phosphate cotransporter
- (21) organic anion transporting
- subfamily 1 (SLCO1A2SLCO1A2Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.-Further reading:...
, SLCO1B1SLCO1B1Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.-Further reading:...
, SLCO1B3SLCO1B3Solute carrier organic anion transporter family member 1B3 also known as organic anion-transporting polypeptide 1B3 is a protein that in humans is encoded by the SLCO1B3 gene....
, SLCO1B4, SLCO1C1) - subfamily 2 (SLCO2A1, SLCO2B1SLCO2B1Solute carrier organic anion transporter family member 2B1 is a protein that in humans is encoded by the SLCO2B1 gene.-Further reading:...
) - subfamily 3 (SLCO3A1SLCO3A1Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.-Further reading:...
) - subfamily 4 (SLCO4A1SLCO4A1Solute carrier organic anion transporter family member 4A1 is a protein that in humans is encoded by the SLCO4A1 gene.-Further reading:...
, SLCO4C1) - subfamily 5 (SLCO5A1)
- subfamily 6 (SLCO6A1)
- subfamily 1 (SLCO1A2
- (22) organic cation/anion/zwitterion transporter
- (SLC22A1SLC22A1Solute carrier family 22 member 1 is a protein that in humans is encoded by the SLC22A1 gene.-Further reading:...
, SLC22A2SLC22A2Solute carrier family 22 member 2 is a protein that in humans is encoded by the SLC22A2 gene.-Further reading:...
, SLC22A3SLC22A3Solute carrier family 22 member 3 also known as the organic cation transporter 3 or extraneuronal monoamine transporter is a protein that in humans is encoded by the SLC22A3 gene.-Distribution:...
, SLC22A4SLC22A4Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is an ergothioneine transporter.- Function :The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments...
, SLC22A5SLC22A5SLC22A5 is a membrane transport protein associated with primary carnitine deficiency.-External links:*...
, SLC22A6, SLC22A7SLC22A7Solute carrier family 22 member 7 is a protein that in humans is encoded by the SLC22A7 gene.-Further reading:...
, SLC22A8SLC22A8Solute carrier family 22 member 8 is a protein that in humans is encoded by the SLC22A8 gene.-Further reading:...
, SLC22A9SLC22A9Solute carrier family 22 member 9 is a protein that in humans is encoded by the SLC22A9 gene.-Further reading:...
, SLC22A10SLC22A10Solute carrier family 22 member 10 , also known as organic anion transporter 5 , is a protein that in humans is encoded by the SLC22A10 gene....
, SLC22A11SLC22A11Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.-Further reading:...
, SLC22A12SLC22A12Solute carrier family 22 , member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.-Function:...
, SLC22A13, SLC22A14, SLC22A15, SLC22A16, SLC22A17, SLC22A18SLC22A18Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.-Further reading:...
, SLC22A19, SLC22A20)
- (SLC22A1
- (23) Na+-dependent ascorbic acid transporter
- (24) Na+/(Ca2+-K+) exchanger
- (SLC24A1, SLC24A2, SLC24A3, SLC24A4, SLC24A5SLC24A5Sodium/potassium/calcium exchanger 5 also known as solute carrier family 24 member 5 is a protein that in humans is encoded by the SLC24A5 gene that has a major influence on natural skin colour variation. The NCKX5 protein is a member of the potassium-dependent sodium/calcium exchanger family...
, SLC24A6)
- (SLC24A1, SLC24A2, SLC24A3, SLC24A4, SLC24A5
- (25) mitochondrial carrierMitochondrial carrierMitochondrial carriers are proteins from the solute carrier family which transfers molecules across the membranes of the mitochondria.- Function :...
- (SLC25A1SLC25A1Tricarboxylate transport protein, mitochondrial is a protein that in humans is encoded by the SLC25A1 gene.-Further reading:...
, SLC25A2, SLC25A3SLC25A3Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene.-Further reading:...
, SLC25A4PendrinPendrin also known as sodium-independent chloride/iodide transporter is a protein that in humans is encoded by the SLC26A4 gene .- Function :Pendrin is an ion exchanger found in the cortical collecting duct....
, SLC25A5, SLC25A6SLC25A6ADP/ATP translocase 3 also known as solute carrier family 25 member 6 is a protein that in humans is encoded by the SLC25A6 gene.Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes....
, SLC25A7, SLC25A8, SLC25A9, SLC25A10SLC25A10Mitochondrial dicarboxylate carrier is a protein that in humans is encoded by the SLC25A10 gene.-Further reading:...
, SLC25A11SLC25A11Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene.-Further reading:...
, SLC25A12SLC25A12Calcium-binding mitochondrial carrier protein Aralar1 is a protein that in humans is encoded by the SLC25A12 gene.-Further reading:...
, SLC25A13CitrinCitrin also known as solute carrier family 25, member 13 or SLC25A13 is a protein which in humans is encoded by the SLC25A13 gene.Citrin is associated with type II citrullinemia....
, SLC25A14SLC25A14Brain mitochondrial carrier protein 1 is a protein that in humans is encoded by the SLC25A14 gene.-Further reading:...
, SLC25A15Ornithine translocaseOrnithine translocase is responsible for transporting ornithine from the cytosol into the mitochondria in the urea cycle.-Pathology:A disorder is associated with ornithine translocase deficiency, and a form of hyperammonemia....
, SLC25A16, SLC25A17SLC25A17Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by the SLC25A17 gene.-Further reading:...
, SLC25A18, SLC25A19SLC25A19Mitochondrial thiamine pyrophosphate carrier is a protein that in humans is encoded by the SLC25A19 gene.-External links:* *...
, SLC25A20Carnitine-acylcarnitine translocaseCarnitine-acylcarnitine translocases are responsible for transporting both carnitine and carnitine-fatty acid complexes into and out of the mitochondria, across the inner mitochondrial membrane.-Function:...
, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27SLC25A27Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.-Further reading:...
, SLC25A28, SLC25A29, SLC25A30, SLC25A31SLC25A31ADP/ATP translocase 4 is an enzyme that in humans is encoded by the SLC25A31 gene.-Further reading:...
, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37SLC25A37Mitoferrin-1 is a protein that in humans is encoded by the SLC25A37 gene.-Further reading:...
, SLC25A38SLC25A38SLC25A38 is a human gene....
, SLC25A39SLC25A39Solute carrier family 25 member 39 is a protein that in humans is encoded by the SLC25A39 gene.-Further reading:...
, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46)
- (SLC25A1
- (26) multifunctional anion exchanger
- (SLC26A1, SLC26A2SLC26A2The SLC26A2 protein is a member of the solute carrier family. In humans, this transporter is encoded by the SLC26A2 gene.- Function :The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias...
, SLC26A3SLC26A3Solute carrier family 26, member 3, also known as SLC26A3, or DRA is a human gene.-Further reading:...
, SLC26A4, SLC26A5, SLC26A6SLC26A6Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.-Further reading:...
, SLC26A7SLC26A7Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.-Further reading:...
, SLC26A8SLC26A8Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.-Interactions:SLC26A8 has been shown to interact with RACGAP1.-Further reading:...
, SLC26A9, SLC26A10, SLC26A11)
- (SLC26A1, SLC26A2
- (27) fatty acid transport proteins
- (SLC27A1SLC27A1Long-chain fatty acid transport protein 1 is a protein that in humans is encoded by the SLC27A1 gene.-Further reading:...
, SLC27A2SLC27A2Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.-Further reading:...
, SLC27A3SLC27A3Long-chain fatty acid transport protein 3 is a protein that in humans is encoded by the SLC27A3 gene.In melanocytic cells SLC27A3 gene expression may be regulated by MITF.-Further reading:...
, SLC27A4SLC27A4Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene.-Further reading:...
, SLC27A5SLC27A5Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.-Further reading:...
, SLC27A6SLC27A6Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.-Further reading:...
)
- (SLC27A1
- (28) Na+-coupled nucleoside transport
- (SLC28A1SLC28A1Concentrative nucleoside transporter 1 is a protein that in humans is encoded by the SLC28A1 gene.- See also :* Solute carrier family* Concentrative nucleoside transporters* Nucleoside transporters- Further reading :...
, SLC28A2SLC28A2Concentrative nucleoside transporter 2 is a protein that in humans is encoded by the SLC28A2 gene.- See also :* Solute carrier family* Concentrative nucleoside transporters* Nucleoside transporters- Further reading :...
, SLC28A3)
- (SLC28A1
- (29) facilitative nucleoside transporter
- (SLC29A1SLC29A1Equilibrative nucleoside transporter 1 is a protein that in humans is encoded by the SLC29A1 gene.- Interactive pathway map :- See also :* Solute carrier family* Equilibrative nucleoside transporters* Nucleoside transporters...
, SLC29A2SLC29A2Equilibrative nucleoside transporter 2 is a protein that in humans is encoded by the SLC29A2 gene.- See also :* Solute carrier family* Equilibrative nucleoside transporters* Nucleoside transporters- Further reading :...
, SLC29A3, SLC29A4SLC29A4Equilibrative nucleoside transporter 4 is a protein that in humans is encoded by the SLC29A4 gene.-Further reading:...
)
- (SLC29A1
- (30) zinc efflux
- (SLC30A1SLC30A1Solute carrier family 30 , member 1 is a protein which in humans is encoded by the SLC30A1 gene.-Function:SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive...
, SLC30A2, SLC30A3, SLC30A4SLC30A4Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.-Further reading:...
, SLC30A5, SLC30A6, SLC30A7SLC30A7Zinc transporter 7 is a protein that in humans is encoded by the SLC30A7 gene.-Further reading:...
, SLC30A8SLC30A8Solute carrier family 30 , member 8, also known as SLC30A8, is a human gene that codes for a zinc transporter related to insulin secretion in humans. Certain alleles of this gene may increase the risk for developing type 2 diabetes....
, SLC30A9, SLC30A10)
- (SLC30A1
- (31) copperCopperCopper is a chemical element with the symbol Cu and atomic number 29. It is a ductile metal with very high thermal and electrical conductivity. Pure copper is soft and malleable; an exposed surface has a reddish-orange tarnish...
transporter- (SLC31A1SLC31A1High affinity copper uptake protein 1 is a protein that in humans is encoded by the SLC31A1 gene.-Further reading:...
)
- (SLC31A1
- (32) vesicular inhibitory amino acid transporter
- (SLC32A1SLC32A1Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.-Further reading:...
)
- (SLC32A1
- (33) Acetyl-CoAAcetyl-CoAAcetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions. Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle to be oxidized for energy production. In chemical structure, acetyl-CoA is the thioester...
transporter- (SLC33A1)
- (34) type II Na+-phosphate cotransporter
- (SLC34A1Sodium/phosphate cotransporterThe sodium/phosphate cotransporter is a protein found in the proximal tubule of the nephron. It is responsible for reabsorbing phosphate that has been filtered out at the glomerulus.-See also:* Renal physiology* Cotransporter...
, SLC34A2SLC34A2Sodium-dependent phosphate transport protein 2B is a protein that in humans is encoded by the SLC34A2 gene.-Further reading:...
, SLC34A3SLC34A3Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.- Function :SLC34A3 contributes to the maintenance of inorganic phosphate concentration at the kidney.-Clinical Correlation:...
)
- (SLC34A1
- (35) nucleoside-sugar transporter
- subfamily A (SLC35A1SLC35A1CMP-sialic acid transporter is a protein that in humans is encoded by the SLC35A1 gene.-External links:*...
, SLC35A2SLC35A2UDP-galactose translocator is a protein that in humans is encoded by the SLC35A2 gene.-Further reading:...
, SLC35A3, SLC35A4, SLC35A5) - subfamily B (SLC35B1, SLC35B2SLC35B2Adenosine 3'-phospho 5'-phosphosulfate transporter 1 is a protein that in humans is encoded by the SLC35B2 gene.-Further reading:...
, SLC35B3, SLC35B4SLC35B4UDP-xylose and UDP-N-acetylglucosamine transporter is a protein that in humans is encoded by the SLC35B4 gene.-Further reading:...
) - subfamily C (SLC35C1SLC35C1GDP-fucose transporter 1 is a protein that in humans is encoded by the SLC35C1 gene.Defects can be associated with Congenital disorder of glycosylation type IIc.-External links:*...
, SLC35C2SLC35C2Solute carrier family 35 member C2 is a protein that in humans is encoded by the SLC35C2 gene.-Further reading:...
) - subfamily D (SLC35D1, SLC35D2, SLC35D3)
- subfamily E (SLC35E1, SLC35E2, SLC35E3, SLC35E4)
- subfamily A (SLC35A1
- (36) proton-coupled amino acid transporter
- (SLC36A1SLC36A1Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.-Further reading:...
, SLC36A2SLC36A2Solute carrier family 36, member 2 also known as SLC36A2 is a protein which in humans is encoded by the SLC36A2 gene.- Function :...
, SLC36A3, SLC36A4)
- (SLC36A1
- (37) sugar-phosphate/phosphate exchanger
- (SLC37A1, SLC37A2, SLC37A3, SLC37A4SLC37A4Glucose-6-phosphate translocase is an enzyme that in humans is encoded by the SLC37A4 gene.-Further reading:...
)
- (SLC37A1, SLC37A2, SLC37A3, SLC37A4
- (38) System A & N, sodium-coupled neutral amino acid transporter
- (SLC38A1SLC38A1Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.-Further reading:...
, SLC38A2SLC38A2Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene.-Further reading:...
, SLC38A3SLC38A3Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the SLC38A3 gene.-Further reading:...
, SLC38A4, SLC38A5, SLC38A6, SLC38A10SLC38A10Sodium-coupled neutral amino acid transporter 10 also known as solute carrier family 38, member 10 is a protein that in humans is encoded by the SLC38A10 gene....
)
- (SLC38A1
- (39) metal ion transporter
- (SLC39A1SLC39A1Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.-Further reading:...
, SLC39A2SLC39A2Zinc transporter ZIP2 is a protein that in humans is encoded by the SLC39A2 gene.-Further reading:...
, SLC39A3SLC39A3Zinc transporter ZIP3 is a protein that in humans is encoded by the SLC39A3 gene.-Further reading:...
, SLC39A4SLC39A4SLC39A4 is a transmembrane protein associated with acrodermatitis enteropathica.-External links:*...
, SLC39A5, SLC39A6SLC39A6Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.-Further reading:...
, SLC39A7SLC39A7Zinc transporter SLC39A7 is a protein that in humans is encoded by the SLC39A7 gene.-Further reading:...
, SLC39A8, SLC39A9, SLC39A10SLC39A10Zinc transporter ZIP10 also known as solute carrier family 39 member 10 is a protein that in humans is encoded by the SLC39A10 gene. ZIP10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters....
, SLC39A11, SLC39A12, SLC39A13, SLC39A14)
- (SLC39A1
- (40) basolateral iron transporter
- (SLC40A1FerroportinFerroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of it. It is found on the surface of cells that store or transport iron, including:*Enterocytes in the duodenum*Hepatocytes...
)
- (SLC40A1
- (41) MgtE-like magnesium transporter
- (SLC41A1, SLC41A2, SLC41A3SLC41A3Solute carrier family 41, member 3 is a protein that in humans is encoded by the SLC41A3 gene....
)
- (SLC41A1, SLC41A2, SLC41A3
- (42) Ammonia transporterAmmonia transporterAmmonia transporters are structurally related membrane transport proteins called Amt proteins , methylammonium/ammonium permeases or RhAG, RhBG, and RhCG Rh family members in mammals. The RhAG, RhBG and RhCG proteins constitute solute carrier family 42...
- (RhAGRHAGRh-associated glycoprotein is an ammonia transporter protein that in humans is encoded by the RHAG gene. RHAG has also recently been designated CD241 . Mutations in the RHAG gene can cause stomatocytosis....
, RhBGRHBGRh family, B glycoprotein, also known as RHBG, is an ammonia transporter protein which in humans is encoded by the RHBG gene.- Function :...
, RhCGRHCGRh family, C glycoprotein, also known as RHCG, is a protein which in humans is encoded by the RHCG gene.- Function :RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney. The structure of the RHCG protein indicates that it has a hydrophobic ammonia-conducting channel thus...
)
- (RhAG
- (43) Na+-independent, system-L like amino acid transporter
- (SLC43A1SLC43A1Large neutral amino acids transporter small subunit 3 is a protein that in humans is encoded by the SLC43A1 gene.-Further reading:...
, SLC43A2, SLC43A3)
- (SLC43A1
- (44) Choline-like transporter
- (SLC44A1SLC44A1Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene.-External links:...
, SLC44A2SLC44A2Choline transporter-like protein 2 is a protein that in humans is encoded by the SLC44A2 gene.-Further reading:...
, SLC44A3, SLC44A4SLC44A4Choline transporter-like protein 4 is a protein that in humans is encoded by the SLC44A4 gene.-Further reading:...
, SLC44A5)
- (SLC44A1
- (45) Putative sugar transporter
- (SLC45A1, SLC45A2SLC45A2Membrane-associated transporter protein also known as solute carrier family 45 member 2 or melanoma antigen AIM1 is a protein that in humans is encoded by the SLC45A2 gene.-Function:...
, SLC54A3, SLC45A4)
- (SLC45A1, SLC45A2
- (46) Folate transporter
- (SLC46A1SLC46A1Solute carrier family 46 , member 1 also known as proton-coupled folate transporter , is a protein which in humans is encoded by the SLC46A1 gene.-Further reading:-External links:*...
, SLC46A2)
- (SLC46A1
- (47) multidrug and toxin extrusionMulti antimicrobial extrusion proteinMulti antimicrobial extrusion protein also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters.- Function :...
- (SLC47A1SLC47A1Multidrug and toxin extrusion protein 1 , also known as solute carrier family 47, member 1, is a protein that in humans is encoded by the SLC47A1 gene...
, SLC47A2SLC47A2Solute carrier family 47, member 2, also known as SLC47A2, is a protein which in humans is encoded by the SLC47A2 gene.- Function :...
)
- (SLC47A1
- (48) Heme transporter
- (49) Transporters of the major facilitator superfamily
- (50) Sugar efflux transporters of the SWEET family
- (51) Transporters of steroid-derived molecules