Streptomyces coelicolor
Encyclopedia
Streptomyces coelicolor is a soil-dwelling Gram-positive
bacterium that belongs to the genus Streptomyces
.
s, including actinorhodin
, methylenomycin
, undecylprodigiosin, and perimycin
. Certain strains of S. coelicolor can used for heterologous protein expression
.
Gram-positive
Gram-positive bacteria are those that are stained dark blue or violet by Gram staining. This is in contrast to Gram-negative bacteria, which cannot retain the crystal violet stain, instead taking up the counterstain and appearing red or pink...
bacterium that belongs to the genus Streptomyces
Streptomyces
Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae. Over 500 species of Streptomyces bacteria have been described. As with the other Actinobacteria, streptomycetes are gram-positive, and have genomes with high guanine and cytosine content...
.
Usage in biotechnology
Strains of S. coelicolor produce various antibioticAntibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
s, including actinorhodin
Actinorhodin
Actinorhodin is a benzoisochromanequinone antibiotic produced by Streptomyces coelicolor....
, methylenomycin
Methylenomycin A
Methylenomycin A is a cyclopentanoid antibiotic produced by Streptomyces coelicolor A3 that is effective against both Gram-negative and Gram-positive bacteria. Methylenomycins are naturally produced in two variants: A and B....
, undecylprodigiosin, and perimycin
Perimycin
Perimycin is polyene antibiotic produced by Streptomyces coelicolor var. aminophilus. The compound exhibits antifungal properties.-Composition:...
. Certain strains of S. coelicolor can used for heterologous protein expression
Heterologous
In medicine a heterologous transplant means 'between species' or 'from one species to another'.In cell biology and protein biochemistry, heterologous expression means that a protein is experimentally put into a cell that does not normally make that protein...
.