Syringetin is a O-methylated flavonol, a type of flavonoid. It is found in red grape (absent in white grape), in Lysimachia congestiflora

Lysimachia congestiflora

Lysimachia congestiflora is a flowering plant species in the genus Lysimachia.Lysimachia congestiflora yields the O-methylated flavonol syringetin....

and in Vaccinium uliginosum

Vaccinium uliginosum

Vaccinium uliginosum is a flowering plant in the genus Vaccinium.-Distribution:Vaccinium uliginosum is native to cool temperate regions of the Northern Hemisphere, at low altitudes in the Arctic, and at high altitudes south to the Pyrenees, the Alps, and the Caucasus in Europe, the mountains of...

(bog billberries). It is one of the phenolic compounds present in wine

Phenolic compounds in wine

The phenolic compounds - natural phenol and polyphenols - in wine include a large group of several hundred chemical compounds that affect the taste, color and mouthfeel of wine. These compounds include phenolic acids, stilbenes, flavonols, dihydroflavonols, anthocyanins, flavanol monomers and...

.

It induces human osteoblast differentiation through bone morphogenetic protein-2

Bone morphogenetic protein 2

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins.-Function:BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine...

/extracellular signal-regulated kinase

Extracellular signal-regulated kinases

In molecular biology, extracellular-signal-regulated kinases or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells...

 1/2 pathway.

Metabolism

Syringetin is formed from laricitrin

Laricitrin

Laricitrin is a O-methylated flavonol, a type of flavonoid. It is found in red grape and in Vaccinium uliginosum . It is one of the phenolic compounds present in wine.-Metabolism:...

 by the action of the enzyme laricitrin 5'-O-methyltransferase (myricetin O-methyltransferase

Myricetin O-methyltransferase

In enzymology, a myricetin O-methyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are S-adenosyl methionine and myricetin, whereas its two products are S-adenosylhomocysteine and syringetin....

).

Glycosides

• syringetin-3-O-galactoside
• Syringetin-3-O-glucoside
• Syringetin 3-rhamnoside (CAS number 93126-00-2)
• Syringetin-3-O-rutinoside found in Larix sibirica
• Syringetin 3-O-(6″-acetyl)-β-glucopyranoside found in Picea abies (Norway spruce)