TetR
Encyclopedia
Tetracycline is a broad family of antibiotics to which bacteria have evolved resistance.
The expression of tc resistance genes is regulated by Tet Repressor Protein, called TetR.
TetR is used in artificially engineered gene regulatory network
s because of its capacity for fine regulation. In the absence of tc, basal expression of TetR is very low, but expression rises sharply in the presence of even a minute quantity of tc through a positive feedback mechanism.
See also Tetracycline controlled transcriptional activation
The expression of tc resistance genes is regulated by Tet Repressor Protein, called TetR.
TetR is used in artificially engineered gene regulatory network
Gene regulatory network
A gene regulatory network or genetic regulatory network is a collection of DNA segments in a cell whichinteract with each other indirectly and with other substances in the cell, thereby governing the rates at which genes in the network are transcribed into mRNA.In general, each mRNA molecule goes...
s because of its capacity for fine regulation. In the absence of tc, basal expression of TetR is very low, but expression rises sharply in the presence of even a minute quantity of tc through a positive feedback mechanism.
See also Tetracycline controlled transcriptional activation