Thyroglobulin type-1 repeat is an evolutionary conserved protein domain

Protein domain

A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...

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Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.

Human proteins containing this domain

CD74

CD74

HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 , is a protein that in humans is encoded by the CD74 gene. The invariant chain is a polypeptide involved in the formation and transport of MHC class II protein...

; IGFBP-4; IGFBP1

IGFBP1

Insulin-like growth factor-binding protein 1 also known as placental protein 12 is a protein that in humans is encoded by the IGFBP1 gene.- Function :...

; IGFBP2

IGFBP2

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene.-Further reading:...

; IGFBP3

IGFBP3

Insulin-like growth factor-binding protein 3, also known as IGFBP3, is a protein that, in humans, is encoded by the IGFBP3 gene.- Function :...

; IGFBP4

IGFBP4

Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. It is secreted by all colon...

; IGFBP5

IGFBP5

Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene.-Further reading:...

; IGFBP6

IGFBP6

Insulin-like growth factor-binding protein 6 is a protein that in humans is encoded by the IGFBP6 gene.-Further reading:...

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NID1; NID2

NID2

Nidogen-2 is a protein that in humans is encoded by the NID2 gene.-Further reading:...

; SMOC1; SMOC2

SMOC2

SPARC-related modular calcium-binding protein 2 is a protein that in humans is encoded by the SMOC2 gene.-Further reading:...

; SPOCK1

SPOCK1

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.-Further reading:...

; SPOCK2

SPOCK2

Testican-2 is a protein that in humans is encoded by the SPOCK2 gene.-Further reading:...

; SPOCK3; TACSTD1;
TACSTD2

TACSTD2

Tumor-associated calcium signal transducer 2 is a protein that in humans is encoded by the TACSTD2 gene.This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It...

; TG

Thyroglobulin

Thyroglobulin is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as colloid....

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