Thyrotrophin-stimulating hormone (also known as TSH or thyrotropin) is a peptide hormone

Peptide hormone

Peptide hormones are a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.Like other proteins, peptide hormones are synthesized in cells from amino acids according to an mRNA template, which is itself synthesized from a DNA template inside the...

 synthesized and secreted by thyrotrope

Thyrotrope

Thyrotropes are endocrine cells in the anterior pituitary which produce thyroid stimulating hormone in response to thyrotropin releasing hormone .Thyrotropes appear basophilic in histological preparations....

 cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid gland.
TSH stimulates the thyroid gland to secrete the hormones thyroxine

Thyroxine

Thyroxine, or 3,5,3',5'-tetraiodothyronine , a form of thyroid hormones, is the major hormone secreted by the follicular cells of the thyroid gland.-Synthesis and regulation:...

 (T₄) and triiodothyronine

Triiodothyronine

Triiodothyronine, C15H12I3NO4, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate....

 (T₃). TSH production is controlled by thyrotropin-releasing hormone

Thyrotropin-releasing hormone

Thyrotropin-releasing hormone , also called thyrotropin-releasing factor , thyroliberin or protirelin, is a tropic tripeptide hormone that stimulates the release of thyroid-stimulating hormone and prolactin by the anterior pituitary...

 (TRH), which is manufactured in the hypothalamus

Hypothalamus

The Hypothalamus is a portion of the brain that contains a number of small nuclei with a variety of functions...

 and transported to the anterior pituitary gland via the hypothalamo-hypophyseal portal system, where it increases TSH production and release.