Tumor-associated glycoprotein

Tumor-associated glycoprotein

Tumor-associated glycoproteins are glycoproteins found on the surface of many cancer cells. They are mucin-like molecules with a molar mass of over 1000 kDa....

 72 (TAG-72) is a glycoprotein

Glycoprotein

Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...

 found on the surface of many cancer cells, including ovary

Ovary

The ovary is an ovum-producing reproductive organ, often found in pairs as part of the vertebrate female reproductive system. Ovaries in anatomically female individuals are analogous to testes in anatomically male individuals, in that they are both gonads and endocrine glands.-Human anatomy:Ovaries...

, breast

Breast

The breast is the upper ventral region of the torso of a primate, in left and right sides, which in a female contains the mammary gland that secretes milk used to feed infants.Both men and women develop breasts from the same embryological tissues...

, colon

Colon (anatomy)

The colon is the last part of the digestive system in most vertebrates; it extracts water and salt from solid wastes before they are eliminated from the body, and is the site in which flora-aided fermentation of unabsorbed material occurs. Unlike the small intestine, the colon does not play a...

, and pancreatic cells. It is a mucin

Mucin

Mucins are a family of high molecular weight, heavily glycosylated proteins produced by epithelial tissues in most metazoans. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell...

-like molecule with a molar mass of over 1000 kDa

KDA

KDA may refer to:* Karachi Development Authority* Kongsberg Defence & Aerospace* Kotelawala Defence Academy* Kramer Design Associates* Lithium diisopropylamide, KDA is the potassium analogue of lithium diisopropylamideOr kDa may refer to:...

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TAG-72 is a a tumor marker

Tumor marker

A tumor marker is a substance found in the blood, urine, or body tissues that can be elevated in cancer, among other tissue types. There are many different tumor markers, each indicative of a particular disease process, and they are used in oncology to help detect the presence of cancer...

 and can be measured with radioimmunoassay

Radioimmunoassay

Radioimmunoassay is a very sensitive in vitro assay technique used to measure concentrations of antigens by use of antibodies...

s like CA 72-4, which uses indium (¹¹¹In) satumomab pendetide and iodine (¹²⁵I) CC49

Iodine (125I) CC49

Iodine CC49 is an iodine-125 radiolabelled monoclonal antibody for the detection of tumours. It is used in radioimmunoassays like CA 72-4.CC49 has also been tested for the treatment of solid tumours, but without success...

 monoclonal antibody. This assay has a good specificity for gastric cancer, with a correlation to the neoplasia's extension. It is used to identify relapses of the disease and to follow up the treatment.

TAG-72 is also the target of the anti-cancer drugs anatumomab mafenatox

Anatumomab mafenatox

Anatumomab mafenatox is a mouse monoclonal antibody for the treatment non-small cell lung cancer.It is a fusion protein of a Fab fragment with an enterotoxin of Staphylococcus aureus....

 and minretumomab

Minretumomab

Minretumomab is a mouse monoclonal antibody designed for the treatment of cancer....

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