A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor

Cytokine receptor

Cytokine receptors are receptors that bind cytokines.In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been...

 that binds tumor necrosis factors

Tumor necrosis factors

Tumor necrosis factors refers to a group of cytokines family that can cause cell death . The first two members of the family to be identified were:...

 (TNF). The receptor cooperates with an adaptor protein

Adaptor protein

Signal transducing adaptor proteins are proteins which are accessory to main proteins in a signal transduction pathway. These proteins tend to lack any intrinsic enzymatic activity themselves but instead mediate specific protein–protein interactions that drive the formation of protein complexes...

 (such as TRADD

TRADD

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.TRADD is an adaptor protein.- Function :...

, TRAF

TRAF

TNF receptor associated factors also known as TRAFs are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis....

, RIP

RIP

R.I.P. is an abbreviation for rest in peace .R.I.P. or RIP may also refer to:-Biology:*Regulated intramembrane proteolysis, a biochemical process which regulates a semipermeable membrane...

), which is important in determining the outcome of the response (e.g. apoptosis, inflammation).

Because "TNF" is often used to describe TNF alpha, "TNFR" is often used to describe the receptors that bind to TNF alpha - namely, CD120

CD120

CD120 , also known as the tumor necrosis factor receptor . This protein is a member of the tumor necrosis factor receptor superfamily.- Receptor subtypes :...

. However, there are several other members of this family that bind to the other TNFs.

Members

Family members include:

Type	Protein	Aliases	Gene
1 (CD120 CD120 CD120 , also known as the tumor necrosis factor receptor . This protein is a member of the tumor necrosis factor receptor superfamily.- Receptor subtypes :... )	CD120a TNFRSF1A Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor...
	CD120b TNFRSF1B Tumor necrosis factor receptor superfamily member 1B is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. The protein encoded by this gene is a member of the...
3	Lymphotoxin β receptor Lymphotoxin beta receptor Lymphotoxin beta receptor is a receptor for lymphotoxin which in humans is encoded by the LTBR gene.-Function:The protein encoded by this gene is a member of the tumor necrosis factor family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid...	TNFRSF3
4	CD134 CD134 CD134, also known as OX40, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary costimulatory molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on...
5	CD40 CD40 (protein) CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects....	TNFRSF5
6	FAS Fas receptor The FAS receptor also known as apoptosis antigen 1 , cluster of differentiation 95 or tumor necrosis factor receptor superfamily member 6 is a protein that in humans is encoded by the TNFRSF6 gene....	TNFRSF6
	TNFRSF6B TNFRSF6B Tumor necrosis factor receptor superfamily member 6B is a protein that in humans is encoded by the TNFRSF6B gene.-Interactions:TNFRSF6B has been shown to interact with TNFSF14 and Fas ligand.-External links:*...
7	CD27 CD27 CD27 is a tumor necrosis factor receptor.-Interactions:CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.-External links:...	TNFRSF7
8	CD30 CD30 CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the...
9	CD137 CD137 CD137 is a member of the tumor necrosis factor receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 , 4-1BB and induced by lymphocyte activation .-Expression:...
10	TNFRSF10A TNFRSF10A Tumor necrosis factor receptor superfamily member 10A is a protein that in humans is encoded by the TNFRSF10A gene. also known as DR4 or TRAIL-R1-Further reading:...	DR4
	TNFRSF10B TNFRSF10B Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, is a human gene.As know as; DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5-Interactions:...	DR5
	TNFRSF10C TNFRSF10C Tumor necrosis factor receptor superfamily member 10C is a protein that in humans is encoded by the TNFRSF10C gene.-Further reading:...
	TNFRSF10D TNFRSF10D Tumor necrosis factor receptor superfamily member 10D is a protein that in humans is encoded by the TNFRSF10D gene.-Further reading:...
11	RANK RANK Receptor Activator of Nuclear Factor κ B , also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding...
	Osteoprotegerin Osteoprotegerin Osteoprotegerin , also known as osteoclastogenesis inhibitory factor , or tumor necrosis factor receptor superfamily member 11B , is a protein that in humans is encoded by the TNFRSF11B gene...
12	TNFRSF12A TNFRSF12A Tumor necrosis factor receptor superfamily member 12A is a protein that in humans is encoded by the TNFRSF12A gene.-Further reading:...	Fn14
13	TNFRSF13B TNFRSF13B Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system....
	TNFRSF13C TNFRSF13C Tumor necrosis factor receptor superfamily member 13C is a protein that in humans is encoded by the TNFRSF13C gene.-Further reading:...
14	TNFRSF14 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 is a protein that in humans is encoded by the TNFRSF14 gene. It is also known as "herpesvirus entry mediator" .-Interactions:...
16	Nerve growth factor receptor Low Affinity Nerve Growth Factor Receptor The Low-Affinity Nerve Growth Factor Receptor is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate...	TNFRSF16
17	TNFRSF17 TNFRSF17 -Interactions:TNFRSF17 has been shown to interact with the B-cell activating factor TNFSF13B. A conserved domain at the N-terminus, BCMA TALL-1 binding domain, is required for binding to the TNFSF13B.-Further reading:...
18	TNFRSF18 TNFRSF18 Tumor necrosis factor receptor superfamily member 18 also known as activation-inducible TNFR family receptor or glucocorticoid-induced TNFR-related protein is a protein that in humans is encoded by the TNFRSF18 gene....
19	TNFRSF19 TNFRSF19 Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.-Further reading:...
21	TNFRSF21 TNFRSF21 Tumor necrosis factor receptor superfamily, member 21, also known as TNFRSF21, is a protein which in humans is encoded by the TNFRSF21 gene.- Function :...	DR6
25	TNFRSF25 TNFRSF25 Tumor necrosis factor receptor superfamily member 25 is a protein that in humans is encoded by the TNFRSF25 gene.-Further reading:...
27	Ectodysplasin A2 receptor EDA2R Tumor necrosis factor receptor superfamily member 27 is a protein that in humans is encoded by the EDA2R gene.EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of...	TNFRSF27