Tumor necrosis factor receptor superfamily member 1A is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the TNFRSF1A gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. The protein encoded by this gene is a member of the Tumor necrosis factor receptor

Tumor necrosis factor receptor

A tumor necrosis factor receptor , or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors . The receptor cooperates with an adaptor protein , which is important in determining the outcome of the response A tumor necrosis factor receptor (TNFR), or death receptor, is a...

 superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor

Transcription factor

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...

 NF-κB, mediate apoptosis

Apoptosis

Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...

, and function as a regulator of inflammation

Inflammation

Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process...

. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction

Signal transduction

Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor. In turn, this receptor alters intracellular molecules creating a response...

 mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder

Genetic disorder

A genetic disorder is an illness caused by abnormalities in genes or chromosomes, especially a condition that is present from before birth. Most genetic disorders are quite rare and affect one person in every several thousands or millions....

 called periodic fever syndrome

Periodic fever syndrome

The periodic fever syndromes are a set of disorders, many of which are genetic disorders in which the mechanisms which initiate and control inflammation are disturbed, leading to uncontrolled inflammation throughout the body...

. Impaired receptor clearance is thought to be a mechanism of the disease.Serum levels of TNFRSF1A are elevated in severe mental disorders

Interactions

TNFRSF1A has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with PSMD2

PSMD2

26S proteasome non-ATPase regulatory subunit 2 is an enzyme that in humans is encoded by the PSMD2 gene.-Interactions:PSMD2 has been shown to interact with TNFRSF1A and PSMC1.-Further reading:...

, FADD

FADD

Fas-Associated protein with Death Domain is an adaptor molecule that bridges the Fas-receptor, and other death receptors, to caspase-8 through its death domain to form the death-inducing signaling complex during apoptosis. -Signalling:...

, Tumor necrosis factor-alpha, BAG4

BAG4

BAG family molecular chaperone regulator 4 is a protein that in humans is encoded by the BAG4 gene.-Interactions:BAG4 has been shown to interact with HSPA8, TNFRSF1A and APOBEC1.-Further reading:...

, Janus kinase 2

Janus kinase 2

Janus kinase 2 is a human protein that has been implicated in signaling by members of the type II cytokine receptor family , the GM-CSF receptor family , the gp130 receptor family , and the single chain receptors...

, IKK2

IKK2

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB gene.- Function :...

, Caspase 10

Caspase 10

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.-Interactions:Caspase 10 has been shown to interact with FADD, CFLAR, Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B.-External links:*...

, Janus kinase 1

Janus kinase 1

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain of type I cytokine receptors, to elicit signals from the IL-2 receptor family , the IL-4 receptor family , the gp130 receptor family JAK1 is a human...

, UBE2I

UBE2I

SUMO-conjugating enzyme UBC9 is a protein that in humans is encoded by the UBE2I gene.-Interactions:UBE2I has been shown to interact with WT1, TOP1, RAD51, Activating transcription factor 2, PIAS1, SALL1, FHIT, RANBP2, Protein inhibitor of activated STAT2, DNMT3A, DNMT3B, Small ubiquitin-related...

, TRPC4AP

TRPC4AP

Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.-Interactions:TRPC4AP has been shown to interact with TNFRSF1A.-References:...

, PIP4K2B

PIP4K2B

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.-Interactions:PIP4K2B has been shown to interact with TNFRSF1A.-Further reading:...

, TRAF2

TRAF2

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.-Interactions:TRAF2 has been shown to interact with BCL10, CD30, CFLAR, IKK2, MAP3K7IP2, CD137, Caveolin 1, CD27, TNFRSF13B, TANK-binding kinase 1, TRAF1, CD40, UBE2N, MAP3K14, MAP4K2, CASP8AP2, HIVEP3,...

, RIPK1

RIPK1

Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.-Interactions:RIPK1 has been shown to interact with CA11, RIPK3, RNF11, Baculoviral IAP repeat-containing protein 3, CFLAR, BIRC2, Caspase 8, RNF216, TNFRSF1A, Sequestosome 1, TRAF2,...

, TRADD

TRADD

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.TRADD is an adaptor protein.- Function :...

 and Small ubiquitin-related modifier 1

Small ubiquitin-related modifier 1

Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene.Most cleft genes have a sumoylation component .-Interactions:...

.

Further reading

External links