Twist transcription factor
Encyclopedia
Twist transcription factor is a basic-helix-loop-helix
transcription factor
associated with Saethre-Chotzen syndrome
.
with EP300
, TCF3
and PCAF
.
Basic-helix-loop-helix
A basic helix-loop-helix is a protein structural motif that characterizes a family of transcription factors.- Structure :The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino...
transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
associated with Saethre-Chotzen syndrome
Saethre-Chotzen syndrome
Saethre-Chotzen syndrome , also known as acrocephalosyndactyly type 3 and Chotzen syndrome, is a very rare autosomal dominant congenital disorder characterized by acrocephalosyndactyly, craniosynostosis...
.
Interactions
Twist transcription factor has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with EP300
EP300
E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...
, TCF3
TCF3
Transcription factor 3 , also known as TCF3, is a protein that in humans is encoded by the TCF3 gene...
and PCAF
PCAF
P300/CBP-associated factor , also known as K acetyltransferase 2B , is a human gene and trancriptional coactivator associated with p53.-Structure:...
.