Tyrima
Encyclopedia
Tyrima is a selective
and reversible inhibitor of MAO-A
(RIMA). It is currently in phase II clinical trial
s for the treatment of depression
.
Binding selectivity
Binding selectivity refers to the differing affinities with which different ligands bind to a substrate forming a complex. A selectivity coefficient is the equilibrium constant for the reaction of displacement by one ligand of another ligand in a complex with the substrate...
and reversible inhibitor of MAO-A
Reversible inhibitor of monoamine oxidase A
Reversible inhibitors of monoamine oxidase A are a class of drugs which selectively and reversibly inhibit the enzyme monoamine oxidase A . They are used clinically in the treatment of depression and dysthymia, though they have not gained widespread market share due to limited efficacy relative to...
(RIMA). It is currently in phase II clinical trial
Clinical trial
Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for health interventions...
s for the treatment of depression
Clinical depression
Major depressive disorder is a mental disorder characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities...
.