UQCRFS1
Encyclopedia
Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 which in humans is encoded by the UQCRFS1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

UQCRFS1 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene:
  • MTCYTB (mitochondrial cytochrome b
    Cytochrome b
    Cytochrome b/b6 is the main subunit of transmembrane cytochrome bc1 and b6f complexes. In addition, it commonly refers to a region of mtDNA used for population genetics and phylogenetics.- Function :...

    )


and ten nuclear genes:
  • UQCRC1
    UQCRC1
    Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase , which consists of the products of one mitochondrially encoded gene, MTCYTB and ten nuclear...

    , UQCRC2
    UQCRC2
    Cytochrome b-c1 complex subunit 2, mitochondrial is a protein that in humans is encoded by the UQCRC2 gene.Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase , which consists of the products of one mitochondrially encoded gene, MTCYTB and ten nuclear...

    , Cytochrome C1
    Cytochrome C1
    Cytochrome C1 is formed in the cytosol and targeted to the mitochondrial intermembrane space. It is one of the constituents of complex III, which forms the third proton pump in the mitochondrial electron transport chain....

    , UQCRFS1 (this protein, a type of Rieske protein
    Rieske protein
    Rieske proteins are iron-sulfur protein components of cytochrome bc1 complexes and cytochrome b6f complexes which were first discovered and isolated by John S. Rieske and co-workers in 1964. It is a unique [2Fe-2S] cluster in that one of the two Fe atoms is coordinated by two histidine residues...

    ), UQCRB
    UQCRB
    Ubiquinol-cytochrome c reductase binding protein, also known as UQCRB, is a protein which in humans is encoded by the UQCRB gene.- Function :...

    , ("11kDa protein"), UQCRH
    UQCRH
    Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the...

     (cyt c1 Hinge protein), UCRC
    UCRC
    Ubiquinol-cytochrome c reductase complex , also known as UCRC or UQCR10, is a human gene.Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase , which consists of the products of one mitochondrially encoded gene, MTCYTB and ten nuclear genes: UQCRC1,...

    ("cyt. c1 associated protein"), and ("Rieske-associated protein").


After processing the cleaved leader sequence of the iron-sulfur protein is retained as subunit 9, giving 11 subunits from 10 genes.

Further reading

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