4-HO-DET, also known as 4-hydroxy-diethyl-tryptamine, CZ-74, or ethocin, is a hallucinogenic drug

Psychedelics, dissociatives and deliriants

This general group of pharmacological agents can be divided into three broad categories: psychedelics, dissociatives, and deliriants. These classes of psychoactive drugs have in common that they can cause subjective changes in perception, thought, emotion and consciousness...

 and psychedelic compound

Psychedelic drug

A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception. Psychedelics are part of a wider class of psychoactive drugs known as hallucinogens, a class that also includes related substances such as dissociatives and deliriants...

 of moderate duration. 4-HO-DET is a substituted

Substitution

Substitution may refer to:- Sciences :* Substitution , a syntactic transformation on strings of symbols of a formal language* Substitution of variables* Substitution cipher, a method of encryption...

 tryptamine

Tryptamine

Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived...

, structurally related to psilocin

Psilocin

Psilocin , an aromatic compound, sometimes also spelled psilocine, psilocyn, or psilotsin, is a psychedelic mushroom alkaloid. It is found in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin...

 and 4-HO-DIPT

4-HO-DIPT

4-Hydroxy-di-isopropyl-tryptamine is a synthetic hallucinogen. It is a close structural analogue of psilocin and classified as a tryptamine derivative.-Effects:...

.

Analogs

The acetic acid

Acetic acid

Acetic acid is an organic compound with the chemical formula CH3CO2H . It is a colourless liquid that when undiluted is also called glacial acetic acid. Acetic acid is the main component of vinegar , and has a distinctive sour taste and pungent smell...

 ester

Ester

Esters are chemical compounds derived by reacting an oxoacid with a hydroxyl compound such as an alcohol or phenol. Esters are usually derived from an inorganic acid or organic acid in which at least one -OH group is replaced by an -O-alkyl group, and most commonly from carboxylic acids and...

 of 4-HO-DET is known as 4-AcO-DET or ethacetin. The phosphoric acid

Phosphoric acid

Phosphoric acid, also known as orthophosphoric acid or phosphoric acid, is a mineral acid having the chemical formula H3PO4. Orthophosphoric acid molecules can combine with themselves to form a variety of compounds which are also referred to as phosphoric acids, but in a more general way...

 ester of 4-HO-DET is known as 4-phosphoryloxy-DET, CEY-19, or ethocybin

Ethocybin

Ethocybin is a homologue of the mushroom alkaloid psilocybin, and a semi-synthetic psychedelic alkaloid of the tryptamine family...

.

History

4-HO-DET received the lab code CZ-74 in the late 1950s by the inventors of the substance, Albert Hofmann

Albert Hofmann

Albert Hofmann was a Swiss scientist known best for being the first person to synthesize, ingest and learn of the psychedelic effects of lysergic acid diethylamide . He authored more than 100 scientific articles and a number of books, including LSD: My Problem Child...

 and Franz Troxler. The substance was used together with its phosporyloxy-analog CEY-19 in human clinical trials in the 1960s by the German researchers Hanscarl Leuner

Hanscarl Leuner

Hanscarl Leuner was a German psychiatrist.His father was a leatherware factory owner. He studium of medicine at Frankfurt University and Marburg University was interrupted by his military service in World War II.He was a pioneer in using Psychoactive drugs for therapy and developed Guided...

 and G. Baer.

Dosage

10-25mg is the usual oral dosage

Effective dose (pharmacology)

An effective dose in pharmacology is the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it....

 for 4-HO-DET, while the acetate

Acetate

An acetate is a derivative of acetic acid. This term includes salts and esters, as well as the anion found in solution. Most of the approximately 5 billion kilograms of acetic acid produced annually in industry are used in the production of acetates, which usually take the form of polymers. In...

 and phosphate

Phosphate

A phosphate, an inorganic chemical, is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry and biogeochemistry or ecology. Inorganic phosphates are mined to obtain phosphorus for use in...

 esters are said to require a slightly higher dosage.

Effects

Ethocin produces entheogen

Entheogen

An entheogen , in the strict sense, is a psychoactive substance used in a religious, shamanic, or spiritual context. Historically, entheogens were mostly derived from plant sources and have been used in a variety of traditional religious contexts...

ic effects similar to LSD

LSD

Lysergic acid diethylamide, abbreviated LSD or LSD-25, also known as lysergide and colloquially as acid, is a semisynthetic psychedelic drug of the ergoline family, well known for its psychological effects which can include altered thinking processes, closed and open eye visuals, synaesthesia, an...

 and psilocybin

Psilocybin

Psilocybin is a naturally occurring psychedelic prodrug, with mind-altering effects similar to those of LSD and mescaline, after it is converted to psilocin. The effects can include altered thinking processes, perceptual distortions, an altered sense of time, and spiritual experiences, as well as...

. Some users have reported unpleasant anxiety

Anxiety

Anxiety is a psychological and physiological state characterized by somatic, emotional, cognitive, and behavioral components. The root meaning of the word anxiety is 'to vex or trouble'; in either presence or absence of psychological stress, anxiety can create feelings of fear, worry, uneasiness,...

 and stimulation

Stimulation

Stimulation is the action of various agents on nerves, muscles, or a sensory end organ, by which activity is evoked; especially, the nervous impulse produced by various agents on nerves, or a sensory end organ, by which the part connected with the nerve is thrown into a state of activity.The word...

 with this drug, while other accounts label the experience as being much milder than LSD or psilocybin.

External links

• TiHKAL 4-HO-DET information at Erowid
  Erowid
  Erowid, also called The Vaults of Erowid, is an online library of information about psychoactive plants and chemicals and other topics on altered states of consciousness such as meditation and lucid dreaming. It provides information about legal and illegal substances, including their desired and...
  
  
• 4-HO-DET entry in TiHKAL • info
• Ethacetin degradation by Murple