ACTA1
Encyclopedia
Actin, alpha skeletal muscle is a protein
that in humans is encoded by the ACTA1 gene
.
with TMSB4X
, MIB2
and PRKCE
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the ACTA1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Skeletal actin gene expression
Skeletal alpha actin expression is induced by stimuli and conditions known to cause muscle formation. Such conditions result in fusion of committed cells (satellite cells) into myotubes, to form muscle fibers. Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation. One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene. SRF may bring a number of other proteins to the promoter of skeletal actin, such as andogen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids.Interactions
Actin, alpha 1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with TMSB4X
TMSB4X
Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene.The protein consists of 44 amino acids molWt 4921.- Function :...
, MIB2
MIB2 (gene)
E3 ubiquitin-protein ligase MIB2 is an enzyme that in humans is encoded by the MIB2 gene.-Interactions:MIB2 has been shown to interact with Actin, alpha 1.-Further reading:...
and PRKCE
PRKCE
Protein kinase C epsilon type is an enzyme that in humans is encoded by the PRKCE gene.- Function :Protein kinase C is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol...
.