B-cell lymphoma 3-encoded protein is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the BCL3 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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This gene is a proto-oncogene

Oncogene

An oncogene is a gene that has the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels.An oncogene is a gene found in the chromosomes of tumor cells whose activation is associated with the initial and continuing conversion of normal cells into cancer...

 candidate. It is identified by its translocation into the immunoglobulin alpha-locus

Locus (genetics)

In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...

 in some cases of B-cell leukemia

B-cell leukemia

B-cell leukemia describes several different types of lymphoid leukemia which affect B cells.Types include :* 9823/3 - B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma* 9826/3 - Acute lymphoblastic leukemia, mature B-cell type...

. The protein encoded by this gene contains seven ankyrin repeat

Ankyrin repeat

The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Ankyrin repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins...

s, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator

Coactivator (genetics)

A coactivator is a protein that increases gene expression by binding to an activator which contains a DNA binding domain. The coactivator is unable to bind DNA by itself....

 that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50

NFKB1

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and...

 NF-kappa B.

Interactions

BCL3 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with PIR

PIR (gene)

Pirin is a protein that in humans is encoded by the PIR gene.-Interactions:PIR has been shown to interact with BCL3.-Further reading:...

, NFKB2

NFKB2

Nuclear factor NF-kappa-B p100 subunit is a protein that in humans is encoded by the NFKB2 gene.-Interactions:NFKB2 has been shown to interact with NFKBIE, BCL3, MAP3K8, BTRC, RELA, RELB, NFKB1, REL and TSC22D3.-Further reading:...

, HTATIP

HTATIP

Histone acetyltransferase KAT5 is an enzyme that in humans is encoded by the KAT5 gene.- Function :The protein encoded by this gene belongs to the MYST family of histone acetyl transferases and was originally isolated as an HIV-1 TAT-interactive protein...

, NFKB1

NFKB1

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and...

, BARD1

BARD1

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene.-Interactions:BARD1 has been shown to interact with BRE, UBE2D1, CSTF2, BRCC3, RAD51, BCL3, TACC1, Ewing sarcoma breakpoint region 1, FANCD2, H2AFX, CSTF1, NPM1, BRCA2, BRCA1, P53 and Aurora B...

, EP300

EP300

E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...

, COP9 constitutive photomorphogenic homolog subunit 5

COP9 constitutive photomorphogenic homolog subunit 5

COP9 constitutive photomorphogenic homolog subunit 5 , also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.-Interactions:...

, C-jun

C-jun

c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the...

, Retinoid X receptor alpha

Retinoid X receptor alpha

Retinoid X receptor alpha , also known as NR2B1 is a nuclear receptor that in humans is encoded by the RXRA gene.- Function :...

 and C-Fos

C-Fos

In the field of molecular biology and Genetics, c-Fos is a protein encoded by the FOS gene.-Structure and function:c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at...

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