BARD1
Encyclopedia
BRCA1-associated RING domain protein 1 is a protein
that in humans is encoded by the BARD1 gene
.
with BRE
, UBE2D1
, CSTF2
, BRCC3
, RAD51
, BCL3
, TACC1
, Ewing sarcoma breakpoint region 1
, FANCD2
, H2AFX
, CSTF1
, NPM1
, BRCA2
, BRCA1
, P53
and Aurora B kinase
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the BARD1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
BARD1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with BRE
BRE (gene)
BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.-Interactions:BRE has been shown to interact with BRCA2, RAD51, BRCC3, BRCA1, C19orf62, P53 and BARD1.-Further reading:...
, UBE2D1
UBE2D1
Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.-Interactions:UBE2D1 has been shown to interact with BARD1, UBE3A and BRCA1.-Further reading:...
, CSTF2
CSTF2
Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.-Interactions:CSTF2 has been shown to interact with CSTF3, SUB1, SYMPK, BARD1 and BRCA1.-Further reading:...
, BRCC3
BRCC3
Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.-Interactions:BRCC3 has been shown to interact with BRE, BRCA2, RAD51, BRCA1, P53 and BARD1.-Further reading:...
, RAD51
RAD51
RAD51 is a human gene. The protein encoded by this gene is a member of the RAD51 protein family which assist in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA and yeast Rad51...
, BCL3
BCL3
B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin...
, TACC1
TACC1
Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.-Interactions:TACC1 has been shown to interact with Aurora A kinase, TDRD7, SNRPG, Aurora B kinase, LSM7, BARD1 and CKAP5.-Further reading:...
, Ewing sarcoma breakpoint region 1
Ewing sarcoma breakpoint region 1
RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene.-Interactions:Ewing sarcoma breakpoint region 1 has been shown to interact with POU4F1, SF1, BARD1, Small nuclear ribonucleoprotein polypeptide C, PTK2B and Zinc finger protein 165.ERG, ATF-1,-External links:* on the...
, FANCD2
FANCD2
Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene. The Fanconi anemia complementation group currently includes FANCA, FANCB, FANCC, FANCD1 , FANCD2 , FANCE, FANCF, FANCG, and FANCL.- Function :Fanconi anemia is a genetically heterogeneous recessive disorder...
, H2AFX
H2AFX
H2AX is one of several genes coding for histone H2A. In humans and other eukaryotes, the DNA is wrapped around histone-groups, consisting of core histones H2A, H2B, H3 and H4. Thus, the H2AX contributes to the histone-formation and therefore the structure of DNA.H2AX becomes phosphorylated on...
, CSTF1
CSTF1
Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.-Further reading:...
, NPM1
NPM1
Nucleophosmin , also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.- Function :...
, BRCA2
BRCA2
BRCA2 is a protein that in humans is encoded by the BRCA2 gene.BRCA2 orthologs have been identified in most mammals for which complete genome data are available....
, BRCA1
BRCA1
BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...
, P53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
and Aurora B kinase
Aurora B kinase
Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere.In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploid cells, a hallmark of cancer....
.