Chang Yi Wang
Encyclopedia
Chang Yi Wang is an immunologist and astute organic chemist, best known for establishing a new platform in vaccines technology that employs designer peptides Peptide
as key ingredients to be formulated into vaccines for the prevention and treatment of AIDS
, HIV
, Alzheimer disease, allergy
and other emerging infectious diseases in both humans and animals. She is the founder of United Biomedical, Inc. (UBI) headquartered in Hauppauge NY Hauppauge, New York
and its group of companies in Asia
. Dr. Wang has served as Chief Scientific Officer of UBI since its inception in December, 1985, and as Chairperson and Chief Executive Officer of the UBI Group of companies from 1998-2011. Dr. Wang is the author of over 120 peer-reviewed scientific publications and the inventor of over 100 patents to date. She has given various plenary lectures in the areas of Immunology
, vaccination, immunotherapeutics and infectious diseases Infectious disease
in many international conferences. She also serves on the scientific review committee for "Cooperative Research Partnerships for BioDefense" and “Allergy and Immunobiology” programs funded/administered by US National Institute of Health (NIH). In 2007, the New York Intellectual Property Law Association (NYIPLA) presented Dr. Wang with the US Inventor of the Year Award.
, Taiwan
, the home of Formosa. She attended the prestigious Taipei First Girls' High School
, where she first became aware of the double helix structure of DNA
which served as one of the primary motivators for her continuous lifetime pursuit of biomedical science. She majored in Chemistry at National Taiwan University
where she graduated summa cum laude in 1973. Subsequently, she was the first Asian woman accepted into the graduate program at the Rockefeller University
in the United States
where she received a Ph.D. degree in 1979 with dual specialization in both Biochemistry
and Immunology
. Thereafter, she joined Memorial Sloan Kettering Cancer Center where she became the youngest faculty member, principal investigator and head of the laboratory of molecular immunology, endowed by the Arthur J. and Leslie Levine Fund, at the Memorial Sloan Kettering Cancer Center from 1979 to 1985 prior to becoming an entrepreneur founding United Biomedical, Inc in the United States
and subsequently its subsidiaries in Asia.
Dr. Wang has been a pioneer in following a path with the concept of “Immunology as a secret weapon of medicine,” combined with a powerful motivation to develop medical interventions through the application of basic biomedical sciences. Her first applications and inventions in the field of immunological applications of Synthetic peptide were antibody screening immunoassays employing highly optimized synthetic viral peptide antigens. First was the development of a synthetic peptide based HIV 1 test and later an HIV 1,2 diagnostic test for blood screening, which received U.S. Food and Drug Administration
approvals in 1989 and 1996, respectively. These tests were subsequently approved by WHO
as suitable for worldwide use. Her other inventions in this area include synthetic peptide-based blood screening diagnostics for HTLV I/II, HCV Hepatitis C virus
, which has CE certification and has been sold in the global market through Organon Teknika /Biomerieux
since 1991, and the SARS Coronavirus, as well as diagnostic tests for the differentiation of infected vs. vaccinated animals for Foot and mouth disease. Since 1992, she has been encouraged by the support and guidance of Dr.James D. Watson
, the co-discoverer of the double-helix structure of DNA Double helix structure in the courageous pursuit of many challenging vaccine and immunotherapeutic programs employing designer synthetic peptides Synthetic peptide. Dr. Wang's United Biomedical, Inc. also received Bill and Melinda Gates Foundation Grand Challenges Explorations grant for a new approach to an AIDS vaccine.
peptide epitopes was the first such patent issued in the United States
for HCV Hepatitis C virus
. Partnering with distributor, Organon Teknika/Biomerieux
, UBI’s peptide antigen based HCV blood screening test was a success in Europe
in early 90s. However, patent litigation ensued between Chiron et al and UBI et al regarding Chiron’s broadly claimed HCV Hepatitis C virus
epitope patent. Six Nobel laureates were involved as expert witnesses in the UK court regarding the validity of the broadly claimed Chiron HCV epitope/peptide patent. As a result of years of litigation through Dr. Wang’s valiant effort to put forth extensive technical arguments challenging the validity of Chiron’s HCV Hepatitis C virus
peptide based claims, UBI’s arguments finally prevailed in 2000 in the European Patent court European patent court presided over by the technical board to invalidate all HCV Hepatitis C virus
peptide based claims, which also resulted in a change in the UK patent law regarding section 44 in that “lack of support can be used to attack the breadth of patent claims even after the patent is issued.” This eventual result freed up the valuable future information to be derived from detailed RNA
or DNA
sequences for the benefit of research and follow up inventions using the vast amount of genomic sequences Genomic sequence generated by the biomedical community .
for the therapy and prevention of chronic and infectious diseases Chronic disease , and corresponding diagnostics for monitoring treatment and control of these diseases. The resultant peptide-based biologicals act by directing the immune system
, and have exceptional potential in a wide range of therapeutic Therapeutic areas.
Under her direction, a new platform technology in peptide immunogen design called “UBITh“ for the development of innovative vaccines and immunotherapeutics was established. Site Specific UBITh Amyloid-β Vaccine Amyloid beta
for Alzheimer disease, AIDS, and severe Allergic Disease Allergy
; and for multiple animal health
applications including pet contraception, Allergy
, boar taint removal Boar taint
and vaccine
against infections caused by Porcine circovirus
, Porcine Reproductive and Respiratory Syndrome Virus
and Foot and mouth disease. Validation for the UBITh vaccine technology has been demonstrated by achievement of the long-sought goal to produce a synthetic peptide vaccine Synthetic peptide for Foot and mouth disease.
, and diagnostic tools.
, China. She has one daughter.
for Immunotherapy of Alzheimer's Disease
Alzheimer's disease
. Vaccine, 2007: 25: 3041-3052.
2. Wang, CY, Walfield, Alan M. Site-specific peptide vaccines for immunotherapy and immunization against chronic diseases, cancer, infectious diseases, and for veterinary applications. [Review Article] Vaccine 2005: 23:2049-2056.
3. Hseuh PR, Kao CL, Lee CN, Chen LK, Ho MS, Sia C, Fang XD, Lynn S, et al and Wang, CY. Highly Specific Severe acute respiratory syndrome
Antibody
Test for Serosurveillance. Emerg. Infect. Diseases 2004, 10:1558-1562
4. Wang, C.Y., Lynn, S., Jong, M-H., Lin, Y-L., et al. Appendix 58, Full protection in pigs against FMDV challenge following single dose of synthetic emergency vaccine. In Report of the Session of the Research Group of the Standing Technical Committee of the European Commission for the Control of Foot-and-Mouth Disease. Food and Agricultural Organization, Rome
, pp. 365–375, 2004.
5. Finstad, CL, Wang, CY, Kowalski J, Zhang M, Li ML, Li XM, Xi WG, Bosland MC, Murthy KK, Walfield AM, and Zamb TJ. Synthetic luteinizing Hormone
releasing hormone (LHRH) vaccine for effective androgen deprivation and its application to Prostate Cancer
immunotheray. Vaccine 2004: 22:1300-1313
6. Wang, CY, Walfield AM, Fang X, Hammerberg B, Ye J, Li ML, Shen F, Shen M, Alexander V and MacGlashan DW. Synthetic IgE peptide vaccine for immunotherapy for Allergy
. Vaccine 2003, 21:1580-1590.
7. Wang, CY, Shen M, Tam G, Fang XD, Ye J, Shen F, Walfield AM, Wang JJG, et al. Synthetic AIDS vaccine by targeting HIV receptor. Vaccine 2002, 21: 89-97.
8. Wang, CY, Chang TY, Walfield AM, Ye J, Shen M, Chen SP, Li MC, Lin YL, et al. Effective Synthetic peptide vaccine for Foot and mouth disease in swine. Vaccine. 2002, 20:2603-2610.
9. Wang, CY, Chang TY, Walfield AM, Ye J, Shen M, Zhang ML, Lubroth J, et al. Synthetic Peptide-based Vaccine and Diagnostic System for Effective Control of Foot and mouth disease. Biologicals 2001, 29: 221-228.
10. Wang, CY, Sawyer LSW, Murthy KK, Fang XD, Walfield AM, et al. Postexposure immunoprophylaxis of primary isolates by an antibody
to HIV
receptor complex. Proc. Natl. Acad. Sci. United States
1999; 96:10367-10372
11. Shen F, Chen PD, Walfield AM, Ye J, House J, Brown F, Wang CY. Differentiation of convalescent animals from those vaccinated against Foot and mouth disease by a peptide ELISA. Vaccine, 1999; 17:3039-3049.
12. Singh M, Li XM, Wang H, McGee JP, Zamb T, Koff W, Wang CY, et. al. Controlled release microparticles as a single dose diphtheria toxoid vaccine; immunogenicity in small animal models. Vaccine 1998; 16:346-352.
13. Singh M. Hio C, Qiu H, Li XM, Wang CY, et al. CTL induction using synthetic peptides delivered in emulsions – critical role of the formulation procedure. Vaccine 1997; 15:1773-1778.
14. Li D, Forrest BD, Li Z, Xue P, Hanson CV, Duan S, Cheng H, Li M, Wang CY, et al. International clinical trials of HIV vaccines: II. Phase I trial of an HIV-1 synthetic peptide vaccine evaluating an accelerated immunization schedule in Yunnan
, China
. Asian Pac J Allergy Immunol 1997; 15: 105-113.
15. Phanuphak P. Teeratakulpixarn S, Sarangbin S, Nookhai S, Ubolyam S, Sirivichayakul S, Leesavan A, Forrest BD, Hanson CV, Li ML, Wang, CY, et al. International clinical trials of HIV vaccines: I. Phase I trial of an HIV-1 synthetic peptide vaccine in Bangkok
, Thailand
. Asian Pac J Allerg Immunol 1997; 15:41-48.
16. Singh M, McGee JP, Li XM, Koff W, Zamb T, Wang CY and O’Hagan DT. Biodegradable microparticles with an entrapped branched octameric peptide as a controlled-release HIV-1 vaccine. J Pharmaceut Sci 1997; 86:1229.
17. Singh M, Li XM, McGee JP, Zamb T, Koff W, Wang CY and O’Hagan DT. Controlled release microparticles as a single dose hepatitis B vaccine; evaluation of immunogenicity in mice. Vaccine 1997; 15:475.
18. Singh M, Li XM, Wang HY, McGee JP, Zamb T, Koff W, Wang CY and O’Hagan DT. Immunogenicity and protection in small-animal models with controlled-release tetanus toxois microparticles as a single-dose vaccine. Infect and Immunity 1997; 65:1716.
19. Nixon DF, Hioe C, Chen PD, Bian Z, Kuebler P, Li ML, Qiu H, Li XM, Singh M, Richardson J, McGee P, Zamb T, Koff W, Wang CY and O’Hagan D. Syntehtic peptides entrapped in microparticles can elicit cytotoxic T cell T cell
activity. Vaccine 1996; 14:1523.
20. Hioe CE, Qiu H, Chen PD, Bian Z, Li ML, Li J, Singh M, Kuebler P, McGee P, O’Hagan D, Zamb T, Koff W, Allsopp C, Wang CY, et al. Comparison of adjuvant formulations for cytotoxic T cell T cell
induction using synthetic peptides. Vaccine 1996: 14:412-418.
21. Quiroga JA, van Binsbergen J, Wang CY, Pardo M, Navas S, Trines C, Herrero M and Carreno V. Immunoglobulin M antibody to hepatitis C virus core antigen: Correlations with viral replication, histological activity, and liver disease Liver disease
outcome. Hepatol 1995; 11:1635.
22. Prince AM, Brotman B, Inchauspe G, Pascual D. Nasoff M. Hosein B and Wang CY. Patterns and prevalence of hepatitis type C infection in post-transfusion non-A, non-B hepatitis. J Inf Dis 1993; 167: 1296-1301.
23. Sheu JC, Wang JT, Wang TH, Wang CY, et al. Prevalence of hepatitis C virul infection in a community in [Taiwan]. Detection by synthetic peptide-based assay and polymerase chain reaction. J Hepatol 1993; 17:192.
24. Wang, CY, Looney, P.J., Li, M.L., Walfield, A.M., Ye, J., Hosein, B., Tam, J.P., and Wong-Staal, F. Long-term high-titer neutralizing activity induced by octameric synthetic HIV
-1 antigen. Science 1991; 254:285-288
25. Hosein B, Fang X and Wang CY. Anti-HCV, anti-GOR, and autoimmunity. Lancet 1992, 339:871.
26. Hosein B, Fang CT, Popvsky MA, Ye J, Zhang M and Wang, CY. Improved serodiagnosis of hepaptis C virus
Hepatitis C
infection with synthetic peptide antigen from capsid protein. Proc Natl Acad Sci USA. 1991; 88:3647.
27. Hosein B, Present W, Wang CY, and Fang CT. synthetic peptide-based EIAs to distinguish HTLV-I from HTLV-II infection. Transfusion 1990; 30S: 513.
28. Kao HT, Gregerson PK, Tang JC, Takahashi T, Wang CY and Silver J, Molecular analysis of HLA class genes in two DR6w-related haplotypes, DRw13 DQw1 and DRw14 DQw3. J Immunol 1989; 142: 1743.
29. Sung SSJ, Bjorndahl JM, Wang CY, Kao HT and Fu SM. Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by PMA and anti-CD3 antibody Anti-CD3 monoclonal antibody
. J Exp Med 1988; 167: 937.
30. Sung SSJ, Jung LKL, Walters JA, Chen W, Wang CY, and Fu SM, Production of tumor necrosis factor/cachetin by human B cell lines and tonsillar B cells. J Exp Med 1988; 168: 1539.
31. Wang CY. Synthetic-peptide-based immunodiagnosis of retrovirus infection: current status and future prospects. In “synthetic Peptides in Biotechnology
.”, Edited by A. Mizrahi, Adv. In Biotechnological Processes. 1988; 10:131.
32. Shimazaki C, Wisniewolski D, Scheinberg D, Atzpodien J, Strife A, Gulati S, Fried J,Wismienolski R, Wang CY and Clarkson B. Elimination of myeloma cells from bone marrow by using Monoclonal antibodies
and magnetic immunobeads. Blood 1988: 72:1248.
33. Gottlieb AB, Lifshitz B, Fu SM, Staiano-Coico L, Wang CY and Carter DM. Expression of HLA-DR molecules by Keratinocytes Keratinocyte
and prescence of Langerhans cells in the dermal infiltrate of active psoriatic plaques. J Exp Med 1986; 164: 1013.
34. Gregerson P, Shen M, Song Q, Wang CY, et al. Molecular diversity of HLA-DR4 haplotypes. Proc Natl. Acad Sci USA 1986; 83: 2642.
35. Rinnooy-Kan EA, Wright SD, Welte K and Wang CY. Fc receptors on monocytes cause OKT-3 treated lymphocytes to internalize T3 and secrete IL-2. Cell Immunol 1986; 98: 181.
36. Buskin Y, Posnett DN, Pernis B and Wang CY. A new HLA-linked T cell
membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3. J Exp Med 1986; 164: 458.
37. Posnett D, Wang CY and Friedman Sm. Inherited polymorphism of the human T cell antigen receptor detected by a monoclonal antibody. Proc Natl. Acad Sci USA 1986; 83:7888.
38. Tse DB, Al-Haiden M, Pernis B, Cantor CR and Wang CY. Intracellular accumulation of T cell
receptor complex molecules in a human T leukemia
cell line. Science 1986; 234:748.
39. Wang JG, Steel S, Wisniewolski R and Wang CY. Detection of antibodies to HTLV-III using a synthetic peptide of 21 amino acide residues corresponding to a highly antigenic segment of gp41 envelope protein. Proc Natl Acad Sci USA 1986; 83:6159.
40. Wang CY, Bushin Y, Lane CL, McGrath H and Posnett DN. Stimulation and expansion of a human T cell subpopulation by a monoclonal antibody to T cell receptor T cell receptor
molecule. Hybridoma 1986; 5:179.
41. Schwarting R, Stein H and Wang CY. monoclonal antibody S-HCL1 and S-HCL3 allow the diagnosis of hairy cell leukemia
. Blood 1985; 65:974.
42. Bushkin Y, Chorney MJ, Diamante E, Lane CL, Fu SM and Wang, CY. Biochemical characteriazation of a p43,12 complex: comparison to human and murine class I molecules. Mol Immunol 1985; 22:695.
43. Schwarting R, Welte K, chiorazzi N, Ralph P, Lane CL, Long CW, and Wang, CY. Biochemical characterization and purificatoin of human B cell stimulatory factory (BSF). Eur J Immunol 1985; 15:632.
44. Wang, CY, Bushkin Y, Chen BPD, Platsoucas C and Long CW. Preparation and characterization of monoclonal antibodies
directed against epitopes of Human IFN-y. Hybridoma 1984; 4:321.
45. Bushkin Y, Chorney MJ, Diamante E, Fu SM and Wang, CY. Biochemical characterization of the human T6 antigen; a comparison between T6 and murine TL. Mol. Immunol 1984; 21:821.
46. Posnett DN, Biegler RD, Bushkin Y, Fisher DE, Wang, CY, Mayer LF, Chiorazzi N and Kunkel HG. T cell anti-idiotypic antibodies reveal differences between two human leukemias. J Exp Med 1984; 160:499.
47. Posnett DN, Wang, CY, Chiorazzi N, Crow MK and Kunkel HG. An antigen characteristic of hairy cell leukemia
cells is expressed on certain activated B cells. J immunol 1984; 133:1635.
48. Peng RL, Al-Katib A, Knowles DM, Lu L, Broxmeyer H, Telidjian B, C Hiao JW and Wang, CY. Preparation and characterization of monoclonal antibodies
recognizing two distinct differentiation antigens Pro-Im1, Pro-Im2 on early hematopoeitic cells. Blood 1984; 64:1169.
49. Rinooy Kan EA, Platzer E, Welte K, and Wang, CY. Modulation induction of the T3 antigen by OKT3 is monocyte dependent. J Immunol 1984; 133:2979.
50. Wang, CY, Azzo W, Al-Katib A, Chiorazzi N and Knowles DM. Preparation and characterization of monoclonal antibodies
recognizing three distinct differentiation antigens (BL1, BL2, and BL3) on human B lymphocytes. J Immunol 1984; 1133:684.
51. Wang, CY, Al-Katib A, Lane CL, Koziner B and Fu, SM. Induction of Leu 10 (HLA-DC/DS) antigen expression by human precurso B cell lines. J Exp Med 1983; 158:1757.
52. Rinooy Kan EA, Wang, CY, Wang LC and Evans RL. Non-covalently bonded subunits of 22KD and 28KD are rapidly internalized by T cells reacted with anti-Leu4 [now termed CD3] antibody. J Immunol 1983; 131:536.
53. Biegler RD, Risher DE, Wang, CY, Rinnooy Kan EA and Kunkel HG. Idiotype-like molecules on cells of a human T-cell leukemia leukemia
. J Exp Med 1983; 158:1000.
54. Welte K, Platzer EW, Wang, CY, Rinnooy Kan EA, Moore MAS and Mertelsmann R. OKT8 [now termed CD8] antibody inhibits OKT3 [now termed CD3]-induced IL-2 production and proliferation of KT8+ cells. J Immunol 1983; 131:2356.
55. Knowles DM, Tolidgian B, Maiboe CC, Halper J, Azzo W and Wang, CY. A new human B lymphocyte surface antigen (BL2) detected by a monoclonal antibodies
: Distribution of benign and malignant lymphoid cells. Blood 1983; 62:191.
56. Venuta S, Mertelsmann R, Welte K, Feldman S, Wang, CY and Moore MAS. Production and regulation of Interleukin-2 in human lymphoblastic leukemias studied with T cell monoclonal antibodies
. Blood 1983; 61:781.
57. Miki Y, Kishi H, Muragachi A, Maruyama S, Kishimoto S, Yamamura Y, Wang, CY and Kishimoto T. Induction of IgG production in a human monoclonal B lymphoblastoid cell line by a B cell-specific monoclonal antibody (BL2). J Immunol 1982; 1290: 1921.
58. Welte K, Wang, CY, Mertelsmann R, Venuta S, Feldman S and Moore MAS. Purification of human Interleukin-2 to apparent homogeneity and its molecular heterogeneity. J Exp Med 1982; 156:454.
59. Shin HS, Wang, CY and Choi YS. Activation of autologous reactive helpter T lymphocytes for differentiation of human B lymphocytes. J Immunol 1981: 126:2483.
60. Wang, CY, Good RA, Ammirati P, Dymbort G and Evans RL. Identification of a p69/71 complex [now termed LEU 1 or CD5] expressed on human T cells sharing determinants with B type chronic lymphatic leukemia. J Exp Med 1980; 151: 1539.
61. Halper J, Knowles DM and Wang, CY. 1a antigen expression by human malignant lymphomas: correlation with conventional lymphoid markers. Blood 1980; 55:373.
62. Gottlieb AB, FU SM, YU DTY, Wang, CY, Halper JP and Kunkel HG. The nature of the stimulation of cell in human allogeneic and autologous MLC reaction: Role of isolated IgM-bearing B cells. J Immunol 1979; 123: 1497.
63. Wang, CY, Structural and functional characterization of surface antigen on human B lymphocyte
. Ph.D. Thesis, The Rockefeller University
, 1979.
64. Wang, CY, Fu SM and Kunkel HG. Isolation and immunological 65. Fu SM, Chiorazzi N, Wang, CY, Montazeri CM and Kunkel HG> 1a beacharacterization of a major surface glycoprotein (gp54 [now termed CD40] preferentially expressed on certain human B cells. J Exp Med 1979; 149:1434.
65. Fu SM, Chiorazzi N, Wang, CY, Montazeri CM and Kunkel HG> 1a bearing T cells in man. Their identification and role in the generation of allogeneic helper activity. J Exp Med 1978; 148:1423.
66. Winchester RJ, Wang, CY, Gibofsky A, Kunkel HG, Lloyd K and Old, LJ. Expression of 1a-like antigens on cultured human malignant melanoma cell lines. Proc Natl. Acad Sci. 1978; 75:6235.
67. Winchester RJ, Meyers PA, Broxmeyer HE, Wang, CY, Moore MAS and Kunkel HG. Inhibition of human erythropoietic colony formation in culture by treatment with 1a antisera. J Exp Med 1978; 148:613.
68. Halper JP, Fu SM, Wang, CY, Winchester RJ and Kunkel HG. Patterns of expression of human 1a-like antigens during the terminal stages of B cell development. J Immunol 1978; 119:1520.
69. Hoffman T, Wang, CY, Winchester RJ, Ferarrini M and Kunkel HG. Human lymphocyte bearing 1a-like antigens [now termed HLA-DK or class 1 MHC antigen]: Absence in patients with infantile Hypogammaglobulinemia
. J immunol 1977; 119:1250.
70. Winchester RJ, Ross, GD, Jarowski CI, Wang, CY, Halper J and Broxmeyer HE. Expression of a 1a-like antigen on human granulocytes during early stages of differentiation. Proc Natl Acad Sci 1977; 74:4012.
• Hsin Chu, Taiwan
- Tsis-Hua University Lecture Series: “From double Helix to efficacious vaccines through rational design” April 10, 2010
• Taipei
,Taiwan Forum on Vaccine Industry Development in Taiwan , Taiwan Biotech Association: “A Reflection and New Determination: Site Directed Vaccines and Immunotherapeutics” [Plenary Lecture] July 24, 2008
• Vienna, Austria
International Atomic Energy Agency (IAEA)/Food and Agriculture Organization (FAO) and Office of International des Epizooties (OIE) World Organization for Animal Health: Use Of Standards and References for Serological And Molecular Tests for Transboundary Diseases In Livestock Nov. 21-24, 2006
• Montreal
, Canada
5th World Congress on Vaccines, Immunization & Immunotherapy [Plenary Lecture] Nov. 6-9, 2006
• Dubai
, UAE 7th Global Vaccinology Forum on Disease Immunization and Immunotherapy: Site-Specific Peptide Vaccines for Immunotherapy and Immunization and for Veterinary Applications [Plenary Lecture] March 5–7, 2005
• Tokyo
, Japan
4th World Congress on Vaccines & Immunization: Site-Specific PeptideB Vaccines for Immunotherapy and Immunization Against Chronic Diseases, Cancer, Infectious Diseases Infectious Disease
, and for Veterinary Applications [Plenary Lecture], Sept. 30-Oct. 3, 2004
• Washington Washington (state), D.C. US-Taiwan Business Council, The Brookings Institute, and the Center for Strategic and International Studies Symposium on The Taiwan Taiwan
Presidential Elections: “Political, Economic, & Security Implications” : Reasons to Choose Taiwan May 6, 2004
• Singapore
Biomedical Asia, Partnering Seminar: UBI as a Rising Star of the Biopharmaceutical Industry Nov. 4, 2003
• San Diego, California
. Days of Molecular Medicine Symposium: Immunotherapy of Infectious, Chronic Diseases and Cancer by Site-Specific Peptide Vaccines
March 13–15, 2003
• Cambridge
, Massachusetts
. Knowledge Foundation’s International Conference on HIV Vaccines: Synthetic AIDS Vaccine by Targeting HIV Receptor June 22–23, 2003
• Tainan
, Taiwan
International Symposium on Agricultural Biotechnology, National Cheng Kung University National Cheng Kung University
: Site Specific Synthetic Peptide Antigens and Functional Antigenics: Applications to Animal Health Dec. 13-14, 2002
• Lyon
, France
Foundation Merieux of International Association of Biologicals Standardization: Immunological Application of Synthetic Peptides May 9–11, 2001
• Amsterdam
, Netherlands
IAVI Neutralization Task Force: Immunoprophylaxis, Immunotherapy, and a Synthetic AIDS
Vaccine Targeting HIV Hiv
Receptors April 25, 2001
• London
, England
HIV Therapeutics: Searching for the Next Generation: Immunoprophylaxis, Immunotherapy, and a Synthetic AIDS Aids
Vaccine Targeting HIV Receptors Feb. 28-Mar 1, 2001
• Baltimore
, Maryland
Meeting of the Institute of Human Virology: Postexposure Immunoprophylaxis of Primary Isolate by an Antibody to HIV Receptor Complex Sept. 15, 2000
Peptide
Peptides are short polymers of amino acid monomers linked by peptide bonds. They are distinguished from proteins on the basis of size, typically containing less than 50 monomer units. The shortest peptides are dipeptides, consisting of two amino acids joined by a single peptide bond...
as key ingredients to be formulated into vaccines for the prevention and treatment of AIDS
AIDS
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the human immunodeficiency virus...
, HIV
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
, Alzheimer disease, allergy
Allergy
An Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur when a person's immune system reacts to normally harmless substances in the environment. A substance that causes a reaction is called an allergen. These reactions are acquired, predictable, and rapid...
and other emerging infectious diseases in both humans and animals. She is the founder of United Biomedical, Inc. (UBI) headquartered in Hauppauge NY Hauppauge, New York
Hauppauge, New York
Hauppauge is a hamlet and CDP in the Town of Islip and the Town of Smithtown in Suffolk County, New York, United States. The population of the CDP was 20,100 at the time of the 2000 census....
and its group of companies in Asia
Asia
Asia is the world's largest and most populous continent, located primarily in the eastern and northern hemispheres. It covers 8.7% of the Earth's total surface area and with approximately 3.879 billion people, it hosts 60% of the world's current human population...
. Dr. Wang has served as Chief Scientific Officer of UBI since its inception in December, 1985, and as Chairperson and Chief Executive Officer of the UBI Group of companies from 1998-2011. Dr. Wang is the author of over 120 peer-reviewed scientific publications and the inventor of over 100 patents to date. She has given various plenary lectures in the areas of Immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
, vaccination, immunotherapeutics and infectious diseases Infectious disease
Infectious disease
Infectious diseases, also known as communicable diseases, contagious diseases or transmissible diseases comprise clinically evident illness resulting from the infection, presence and growth of pathogenic biological agents in an individual host organism...
in many international conferences. She also serves on the scientific review committee for "Cooperative Research Partnerships for BioDefense" and “Allergy and Immunobiology” programs funded/administered by US National Institute of Health (NIH). In 2007, the New York Intellectual Property Law Association (NYIPLA) presented Dr. Wang with the US Inventor of the Year Award.
Early life and academic education
Dr. Wang was born in TaipeiTaipei
Taipei City is the capital of the Republic of China and the central city of the largest metropolitan area of Taiwan. Situated at the northern tip of the island, Taipei is located on the Tamsui River, and is about 25 km southwest of Keelung, its port on the Pacific Ocean...
, Taiwan
Taiwan
Taiwan , also known, especially in the past, as Formosa , is the largest island of the same-named island group of East Asia in the western Pacific Ocean and located off the southeastern coast of mainland China. The island forms over 99% of the current territory of the Republic of China following...
, the home of Formosa. She attended the prestigious Taipei First Girls' High School
Taipei First Girls' High School
Taipei First Girls' High School is a prestigious Taiwanese high school, located in Zhongzheng District within Taipei City, with only the top 1% of scorers on the Basic Competence Test for Junior High School Students receiving admission.- Overview :The school was founded in 1904 and named as...
, where she first became aware of the double helix structure of DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
which served as one of the primary motivators for her continuous lifetime pursuit of biomedical science. She majored in Chemistry at National Taiwan University
National Taiwan University
National Taiwan University is a national co-educational university located in Taipei, Republic of China . In Taiwan, it is colloquially known as "Táidà" . Its main campus is set upon 1,086,167 square meters in Taipei's Da'an District. In addition, the university has 6 other campuses in Taiwan,...
where she graduated summa cum laude in 1973. Subsequently, she was the first Asian woman accepted into the graduate program at the Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...
in the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
where she received a Ph.D. degree in 1979 with dual specialization in both Biochemistry
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
and Immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
. Thereafter, she joined Memorial Sloan Kettering Cancer Center where she became the youngest faculty member, principal investigator and head of the laboratory of molecular immunology, endowed by the Arthur J. and Leslie Levine Fund, at the Memorial Sloan Kettering Cancer Center from 1979 to 1985 prior to becoming an entrepreneur founding United Biomedical, Inc in the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
and subsequently its subsidiaries in Asia.
Career in immunology and as an entrepreneur in the biomedical industry
Dr. Wang has been a pioneer in following a path with the concept of “Immunology as a secret weapon of medicine,” combined with a powerful motivation to develop medical interventions through the application of basic biomedical sciences. Her first applications and inventions in the field of immunological applications of Synthetic peptide were antibody screening immunoassays employing highly optimized synthetic viral peptide antigens. First was the development of a synthetic peptide based HIV 1 test and later an HIV 1,2 diagnostic test for blood screening, which received U.S. Food and Drug Administration
Food and Drug Administration
The Food and Drug Administration is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments...
approvals in 1989 and 1996, respectively. These tests were subsequently approved by WHO
Who
Who may refer to:* Who , an English-language pronoun* who , a Unix command* Who?, one of the Five Ws in journalism- Art and entertainment :* Who? , a 1958 novel by Algis Budrys...
as suitable for worldwide use. Her other inventions in this area include synthetic peptide-based blood screening diagnostics for HTLV I/II, HCV Hepatitis C virus
Hepatitis C virus
Hepatitis C virus is a small , enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae...
, which has CE certification and has been sold in the global market through Organon Teknika /Biomerieux
BioMérieux
bioMérieux is a multinational biotechnology company founded and headquartered in France and listed on the NYSE Euronext Paris stock exchange. The company specializes in the field of in vitro diagnostics for the medical and industrial sectors...
since 1991, and the SARS Coronavirus, as well as diagnostic tests for the differentiation of infected vs. vaccinated animals for Foot and mouth disease. Since 1992, she has been encouraged by the support and guidance of Dr.James D. Watson
James D. Watson
James Dewey Watson is an American molecular biologist, geneticist, and zoologist, best known as one of the co-discoverers of the structure of DNA in 1953 with Francis Crick...
, the co-discoverer of the double-helix structure of DNA Double helix structure in the courageous pursuit of many challenging vaccine and immunotherapeutic programs employing designer synthetic peptides Synthetic peptide. Dr. Wang's United Biomedical, Inc. also received Bill and Melinda Gates Foundation Grand Challenges Explorations grant for a new approach to an AIDS vaccine.
A pioneer to challenge the broad peptide claims of Chiron’s worldwide HCV patent
Dr. Wang‘s patent for diagnostic HCV Hepatitis C virusHepatitis C virus
Hepatitis C virus is a small , enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae...
peptide epitopes was the first such patent issued in the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
for HCV Hepatitis C virus
Hepatitis C virus
Hepatitis C virus is a small , enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae...
. Partnering with distributor, Organon Teknika/Biomerieux
BioMérieux
bioMérieux is a multinational biotechnology company founded and headquartered in France and listed on the NYSE Euronext Paris stock exchange. The company specializes in the field of in vitro diagnostics for the medical and industrial sectors...
, UBI’s peptide antigen based HCV blood screening test was a success in Europe
Europe
Europe is, by convention, one of the world's seven continents. Comprising the westernmost peninsula of Eurasia, Europe is generally 'divided' from Asia to its east by the watershed divides of the Ural and Caucasus Mountains, the Ural River, the Caspian and Black Seas, and the waterways connecting...
in early 90s. However, patent litigation ensued between Chiron et al and UBI et al regarding Chiron’s broadly claimed HCV Hepatitis C virus
Hepatitis C virus
Hepatitis C virus is a small , enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae...
epitope patent. Six Nobel laureates were involved as expert witnesses in the UK court regarding the validity of the broadly claimed Chiron HCV epitope/peptide patent. As a result of years of litigation through Dr. Wang’s valiant effort to put forth extensive technical arguments challenging the validity of Chiron’s HCV Hepatitis C virus
Hepatitis C virus
Hepatitis C virus is a small , enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae...
peptide based claims, UBI’s arguments finally prevailed in 2000 in the European Patent court European patent court presided over by the technical board to invalidate all HCV Hepatitis C virus
Hepatitis C virus
Hepatitis C virus is a small , enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae...
peptide based claims, which also resulted in a change in the UK patent law regarding section 44 in that “lack of support can be used to attack the breadth of patent claims even after the patent is issued.” This eventual result freed up the valuable future information to be derived from detailed RNA
RNA
Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....
or DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
sequences for the benefit of research and follow up inventions using the vast amount of genomic sequences Genomic sequence generated by the biomedical community .
A pioneer in designer peptide based vaccines and immunotherapeutics as a new class of biologicals
For the past 25 years, Dr. Wang has dedicated herself to the discovery and development of a new class of biologicals comprising Immunotherapeutics and vaccineVaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...
for the therapy and prevention of chronic and infectious diseases Chronic disease , and corresponding diagnostics for monitoring treatment and control of these diseases. The resultant peptide-based biologicals act by directing the immune system
Immune system
An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumor cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own...
, and have exceptional potential in a wide range of therapeutic Therapeutic areas.
Under her direction, a new platform technology in peptide immunogen design called “UBITh“ for the development of innovative vaccines and immunotherapeutics was established. Site Specific UBITh Amyloid-β Vaccine Amyloid beta
Amyloid beta
Amyloid beta is a peptide of 36–43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease...
for Alzheimer disease, AIDS, and severe Allergic Disease Allergy
Allergy
An Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur when a person's immune system reacts to normally harmless substances in the environment. A substance that causes a reaction is called an allergen. These reactions are acquired, predictable, and rapid...
; and for multiple animal health
Animal Health
Animal Health is the UK government's executive agency primarily responsible for ensuring that farmed animals in Great Britain are healthy, disease-free and well looked after....
applications including pet contraception, Allergy
Allergy
An Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur when a person's immune system reacts to normally harmless substances in the environment. A substance that causes a reaction is called an allergen. These reactions are acquired, predictable, and rapid...
, boar taint removal Boar taint
Boar taint
Boar taint is the offensive odour or taste that can be evident during the cooking or eating of pork or pork products derived from non-castrated male pigs once they reach puberty...
and vaccine
Vaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...
against infections caused by Porcine circovirus
Porcine circovirus
Porcine circovirus is a single-stranded DNA virus , that is nonenveloped with an unsegmented circular genome. The viral capsid is icosahedral and approximately 17 nm in diameter. PCV is a member of the virus family Circoviridae....
, Porcine Reproductive and Respiratory Syndrome Virus
Porcine Reproductive and Respiratory Syndrome Virus
Porcine reproductive and respiratory syndrome virus , also known as blue-ear pig disease , is a virus that causes a disease of pigs, called porcine reproductive and respiratory syndrome . This economically important, pandemic disease causes reproductive failure in breeding stock and respiratory...
and Foot and mouth disease. Validation for the UBITh vaccine technology has been demonstrated by achievement of the long-sought goal to produce a synthetic peptide vaccine Synthetic peptide for Foot and mouth disease.
First Asian woman to receive New York Intellectual Property Law Association (NYIPLA) Inventor of the Year Award
The Inventor of the Year award recognizes an individual or group who, through inventive talents, has made worthwhile contributions to society by promoting “the progress of Science and useful Arts.” Dr. Chang Yi Wang was the 2007 award recipient for her work in “UBITh Peptide Immunogens.” The inventions supporting the nomination of Dr. Wang are her synthetic peptide-based immunotherapeutics Synthetic peptide, vaccines VaccineVaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...
, and diagnostic tools.
Personal life
Dr. Wang divides her time between United States, Taiwan and China for her R&D and business development activities in biomedical applications. Her husband Nean Hu devotes his time to UBI’s subsidiaries in ShanghaiShanghai
Shanghai is the largest city by population in China and the largest city proper in the world. It is one of the four province-level municipalities in the People's Republic of China, with a total population of over 23 million as of 2010...
, China. She has one daughter.
Selected scientific publications
1. Wang, CY, Finstad, Connie L., Walfield, Alan M., Sia Charles, Sokoll, Kenneth K., et. al. Site Specific UBITh Amyloid-β Vaccine Amyloid betaAmyloid beta
Amyloid beta is a peptide of 36–43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease...
for Immunotherapy of Alzheimer's Disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
. Vaccine, 2007: 25: 3041-3052.
2. Wang, CY, Walfield, Alan M. Site-specific peptide vaccines for immunotherapy and immunization against chronic diseases, cancer, infectious diseases, and for veterinary applications. [Review Article] Vaccine 2005: 23:2049-2056.
3. Hseuh PR, Kao CL, Lee CN, Chen LK, Ho MS, Sia C, Fang XD, Lynn S, et al and Wang, CY. Highly Specific Severe acute respiratory syndrome
Severe acute respiratory syndrome
Severe Acute Respiratory Syndrome is a respiratory disease in humans which is caused by the SARS coronavirus . Between November 2002 and July 2003 an outbreak of SARS in Hong Kong nearly became a pandemic, with 8,422 cases and 916 deaths worldwide according to the WHO...
Antibody
Antibody
An antibody, also known as an immunoglobulin, is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, termed an antigen...
Test for Serosurveillance. Emerg. Infect. Diseases 2004, 10:1558-1562
4. Wang, C.Y., Lynn, S., Jong, M-H., Lin, Y-L., et al. Appendix 58, Full protection in pigs against FMDV challenge following single dose of synthetic emergency vaccine. In Report of the Session of the Research Group of the Standing Technical Committee of the European Commission for the Control of Foot-and-Mouth Disease. Food and Agricultural Organization, Rome
Rome
Rome is the capital of Italy and the country's largest and most populated city and comune, with over 2.7 million residents in . The city is located in the central-western portion of the Italian Peninsula, on the Tiber River within the Lazio region of Italy.Rome's history spans two and a half...
, pp. 365–375, 2004.
5. Finstad, CL, Wang, CY, Kowalski J, Zhang M, Li ML, Li XM, Xi WG, Bosland MC, Murthy KK, Walfield AM, and Zamb TJ. Synthetic luteinizing Hormone
Hormone
A hormone is a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. In essence, it is a chemical messenger that transports a signal from one...
releasing hormone (LHRH) vaccine for effective androgen deprivation and its application to Prostate Cancer
Prostate cancer
Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers. The cancer cells may metastasize from the prostate to other parts of the body, particularly...
immunotheray. Vaccine 2004: 22:1300-1313
6. Wang, CY, Walfield AM, Fang X, Hammerberg B, Ye J, Li ML, Shen F, Shen M, Alexander V and MacGlashan DW. Synthetic IgE peptide vaccine for immunotherapy for Allergy
Allergy
An Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur when a person's immune system reacts to normally harmless substances in the environment. A substance that causes a reaction is called an allergen. These reactions are acquired, predictable, and rapid...
. Vaccine 2003, 21:1580-1590.
7. Wang, CY, Shen M, Tam G, Fang XD, Ye J, Shen F, Walfield AM, Wang JJG, et al. Synthetic AIDS vaccine by targeting HIV receptor. Vaccine 2002, 21: 89-97.
8. Wang, CY, Chang TY, Walfield AM, Ye J, Shen M, Chen SP, Li MC, Lin YL, et al. Effective Synthetic peptide vaccine for Foot and mouth disease in swine. Vaccine. 2002, 20:2603-2610.
9. Wang, CY, Chang TY, Walfield AM, Ye J, Shen M, Zhang ML, Lubroth J, et al. Synthetic Peptide-based Vaccine and Diagnostic System for Effective Control of Foot and mouth disease. Biologicals 2001, 29: 221-228.
10. Wang, CY, Sawyer LSW, Murthy KK, Fang XD, Walfield AM, et al. Postexposure immunoprophylaxis of primary isolates by an antibody
Antibody
An antibody, also known as an immunoglobulin, is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, termed an antigen...
to HIV
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
receptor complex. Proc. Natl. Acad. Sci. United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
1999; 96:10367-10372
11. Shen F, Chen PD, Walfield AM, Ye J, House J, Brown F, Wang CY. Differentiation of convalescent animals from those vaccinated against Foot and mouth disease by a peptide ELISA. Vaccine, 1999; 17:3039-3049.
12. Singh M, Li XM, Wang H, McGee JP, Zamb T, Koff W, Wang CY, et. al. Controlled release microparticles as a single dose diphtheria toxoid vaccine; immunogenicity in small animal models. Vaccine 1998; 16:346-352.
13. Singh M. Hio C, Qiu H, Li XM, Wang CY, et al. CTL induction using synthetic peptides delivered in emulsions – critical role of the formulation procedure. Vaccine 1997; 15:1773-1778.
14. Li D, Forrest BD, Li Z, Xue P, Hanson CV, Duan S, Cheng H, Li M, Wang CY, et al. International clinical trials of HIV vaccines: II. Phase I trial of an HIV-1 synthetic peptide vaccine evaluating an accelerated immunization schedule in Yunnan
Yunnan
Yunnan is a province of the People's Republic of China, located in the far southwest of the country spanning approximately and with a population of 45.7 million . The capital of the province is Kunming. The province borders Burma, Laos, and Vietnam.Yunnan is situated in a mountainous area, with...
, China
China
Chinese civilization may refer to:* China for more general discussion of the country.* Chinese culture* Greater China, the transnational community of ethnic Chinese.* History of China* Sinosphere, the area historically affected by Chinese culture...
. Asian Pac J Allergy Immunol 1997; 15: 105-113.
15. Phanuphak P. Teeratakulpixarn S, Sarangbin S, Nookhai S, Ubolyam S, Sirivichayakul S, Leesavan A, Forrest BD, Hanson CV, Li ML, Wang, CY, et al. International clinical trials of HIV vaccines: I. Phase I trial of an HIV-1 synthetic peptide vaccine in Bangkok
Bangkok
Bangkok is the capital and largest urban area city in Thailand. It is known in Thai as Krung Thep Maha Nakhon or simply Krung Thep , meaning "city of angels." The full name of Bangkok is Krung Thep Mahanakhon Amon Rattanakosin Mahintharayutthaya Mahadilok Phop Noppharat Ratchathani Burirom...
, Thailand
Thailand
Thailand , officially the Kingdom of Thailand , formerly known as Siam , is a country located at the centre of the Indochina peninsula and Southeast Asia. It is bordered to the north by Burma and Laos, to the east by Laos and Cambodia, to the south by the Gulf of Thailand and Malaysia, and to the...
. Asian Pac J Allerg Immunol 1997; 15:41-48.
16. Singh M, McGee JP, Li XM, Koff W, Zamb T, Wang CY and O’Hagan DT. Biodegradable microparticles with an entrapped branched octameric peptide as a controlled-release HIV-1 vaccine. J Pharmaceut Sci 1997; 86:1229.
17. Singh M, Li XM, McGee JP, Zamb T, Koff W, Wang CY and O’Hagan DT. Controlled release microparticles as a single dose hepatitis B vaccine; evaluation of immunogenicity in mice. Vaccine 1997; 15:475.
18. Singh M, Li XM, Wang HY, McGee JP, Zamb T, Koff W, Wang CY and O’Hagan DT. Immunogenicity and protection in small-animal models with controlled-release tetanus toxois microparticles as a single-dose vaccine. Infect and Immunity 1997; 65:1716.
19. Nixon DF, Hioe C, Chen PD, Bian Z, Kuebler P, Li ML, Qiu H, Li XM, Singh M, Richardson J, McGee P, Zamb T, Koff W, Wang CY and O’Hagan D. Syntehtic peptides entrapped in microparticles can elicit cytotoxic T cell T cell
T cell
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells , by the presence of a T cell receptor on the cell surface. They are...
activity. Vaccine 1996; 14:1523.
20. Hioe CE, Qiu H, Chen PD, Bian Z, Li ML, Li J, Singh M, Kuebler P, McGee P, O’Hagan D, Zamb T, Koff W, Allsopp C, Wang CY, et al. Comparison of adjuvant formulations for cytotoxic T cell T cell
T cell
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells , by the presence of a T cell receptor on the cell surface. They are...
induction using synthetic peptides. Vaccine 1996: 14:412-418.
21. Quiroga JA, van Binsbergen J, Wang CY, Pardo M, Navas S, Trines C, Herrero M and Carreno V. Immunoglobulin M antibody to hepatitis C virus core antigen: Correlations with viral replication, histological activity, and liver disease Liver disease
Liver disease
Liver disease is a broad term describing any single number of diseases affecting the liver.-Diseases:* Hepatitis, inflammation of the liver, caused mainly by various viruses but also by some poisons , autoimmunity or hereditary conditions...
outcome. Hepatol 1995; 11:1635.
22. Prince AM, Brotman B, Inchauspe G, Pascual D. Nasoff M. Hosein B and Wang CY. Patterns and prevalence of hepatitis type C infection in post-transfusion non-A, non-B hepatitis. J Inf Dis 1993; 167: 1296-1301.
23. Sheu JC, Wang JT, Wang TH, Wang CY, et al. Prevalence of hepatitis C virul infection in a community in [Taiwan]. Detection by synthetic peptide-based assay and polymerase chain reaction. J Hepatol 1993; 17:192.
24. Wang, CY, Looney, P.J., Li, M.L., Walfield, A.M., Ye, J., Hosein, B., Tam, J.P., and Wong-Staal, F. Long-term high-titer neutralizing activity induced by octameric synthetic HIV
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
-1 antigen. Science 1991; 254:285-288
25. Hosein B, Fang X and Wang CY. Anti-HCV, anti-GOR, and autoimmunity. Lancet 1992, 339:871.
26. Hosein B, Fang CT, Popvsky MA, Ye J, Zhang M and Wang, CY. Improved serodiagnosis of hepaptis C virus
Hepatitis C
Hepatitis C
Hepatitis C is an infectious disease primarily affecting the liver, caused by the hepatitis C virus . The infection is often asymptomatic, but chronic infection can lead to scarring of the liver and ultimately to cirrhosis, which is generally apparent after many years...
infection with synthetic peptide antigen from capsid protein. Proc Natl Acad Sci USA. 1991; 88:3647.
27. Hosein B, Present W, Wang CY, and Fang CT. synthetic peptide-based EIAs to distinguish HTLV-I from HTLV-II infection. Transfusion 1990; 30S: 513.
28. Kao HT, Gregerson PK, Tang JC, Takahashi T, Wang CY and Silver J, Molecular analysis of HLA class genes in two DR6w-related haplotypes, DRw13 DQw1 and DRw14 DQw3. J Immunol 1989; 142: 1743.
29. Sung SSJ, Bjorndahl JM, Wang CY, Kao HT and Fu SM. Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by PMA and anti-CD3 antibody Anti-CD3 monoclonal antibody
Anti-CD3 monoclonal antibody
An Anti-CD3 monoclonal antibody is one that binds to CD3 on the surface of T cells. They are immunosuppresive drugs.The first to be approved was muromonab-CD3 in 1986, to treat transplant rejection....
. J Exp Med 1988; 167: 937.
30. Sung SSJ, Jung LKL, Walters JA, Chen W, Wang CY, and Fu SM, Production of tumor necrosis factor/cachetin by human B cell lines and tonsillar B cells. J Exp Med 1988; 168: 1539.
31. Wang CY. Synthetic-peptide-based immunodiagnosis of retrovirus infection: current status and future prospects. In “synthetic Peptides in Biotechnology
Biotechnology
Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bioproducts. Biotechnology also utilizes these products for manufacturing purpose...
.”, Edited by A. Mizrahi, Adv. In Biotechnological Processes. 1988; 10:131.
32. Shimazaki C, Wisniewolski D, Scheinberg D, Atzpodien J, Strife A, Gulati S, Fried J,Wismienolski R, Wang CY and Clarkson B. Elimination of myeloma cells from bone marrow by using Monoclonal antibodies
Monoclonal antibodies
Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....
and magnetic immunobeads. Blood 1988: 72:1248.
33. Gottlieb AB, Lifshitz B, Fu SM, Staiano-Coico L, Wang CY and Carter DM. Expression of HLA-DR molecules by Keratinocytes Keratinocyte
Keratinocyte
Keratinocytes are the predominant cell type in the epidermis, the outermost layer of the human skin, constituting 95% of the cells found there. Those keratinocytes found in the basal layer of the skin are sometimes referred to as "basal cells" or "basal keratinocytes"...
and prescence of Langerhans cells in the dermal infiltrate of active psoriatic plaques. J Exp Med 1986; 164: 1013.
34. Gregerson P, Shen M, Song Q, Wang CY, et al. Molecular diversity of HLA-DR4 haplotypes. Proc Natl. Acad Sci USA 1986; 83: 2642.
35. Rinnooy-Kan EA, Wright SD, Welte K and Wang CY. Fc receptors on monocytes cause OKT-3 treated lymphocytes to internalize T3 and secrete IL-2. Cell Immunol 1986; 98: 181.
36. Buskin Y, Posnett DN, Pernis B and Wang CY. A new HLA-linked T cell
T cell
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells , by the presence of a T cell receptor on the cell surface. They are...
membrane molecule, related to the beta chain of the clonotypic receptor, is associated with T3. J Exp Med 1986; 164: 458.
37. Posnett D, Wang CY and Friedman Sm. Inherited polymorphism of the human T cell antigen receptor detected by a monoclonal antibody. Proc Natl. Acad Sci USA 1986; 83:7888.
38. Tse DB, Al-Haiden M, Pernis B, Cantor CR and Wang CY. Intracellular accumulation of T cell
T cell
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells , by the presence of a T cell receptor on the cell surface. They are...
receptor complex molecules in a human T leukemia
Leukemia
Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...
cell line. Science 1986; 234:748.
39. Wang JG, Steel S, Wisniewolski R and Wang CY. Detection of antibodies to HTLV-III using a synthetic peptide of 21 amino acide residues corresponding to a highly antigenic segment of gp41 envelope protein. Proc Natl Acad Sci USA 1986; 83:6159.
40. Wang CY, Bushin Y, Lane CL, McGrath H and Posnett DN. Stimulation and expansion of a human T cell subpopulation by a monoclonal antibody to T cell receptor T cell receptor
T cell receptor
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex molecules...
molecule. Hybridoma 1986; 5:179.
41. Schwarting R, Stein H and Wang CY. monoclonal antibody S-HCL1 and S-HCL3 allow the diagnosis of hairy cell leukemia
Leukemia
Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...
. Blood 1985; 65:974.
42. Bushkin Y, Chorney MJ, Diamante E, Lane CL, Fu SM and Wang, CY. Biochemical characteriazation of a p43,12 complex: comparison to human and murine class I molecules. Mol Immunol 1985; 22:695.
43. Schwarting R, Welte K, chiorazzi N, Ralph P, Lane CL, Long CW, and Wang, CY. Biochemical characterization and purificatoin of human B cell stimulatory factory (BSF). Eur J Immunol 1985; 15:632.
44. Wang, CY, Bushkin Y, Chen BPD, Platsoucas C and Long CW. Preparation and characterization of monoclonal antibodies
Monoclonal antibodies
Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....
directed against epitopes of Human IFN-y. Hybridoma 1984; 4:321.
45. Bushkin Y, Chorney MJ, Diamante E, Fu SM and Wang, CY. Biochemical characterization of the human T6 antigen; a comparison between T6 and murine TL. Mol. Immunol 1984; 21:821.
46. Posnett DN, Biegler RD, Bushkin Y, Fisher DE, Wang, CY, Mayer LF, Chiorazzi N and Kunkel HG. T cell anti-idiotypic antibodies reveal differences between two human leukemias. J Exp Med 1984; 160:499.
47. Posnett DN, Wang, CY, Chiorazzi N, Crow MK and Kunkel HG. An antigen characteristic of hairy cell leukemia
Leukemia
Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...
cells is expressed on certain activated B cells. J immunol 1984; 133:1635.
48. Peng RL, Al-Katib A, Knowles DM, Lu L, Broxmeyer H, Telidjian B, C Hiao JW and Wang, CY. Preparation and characterization of monoclonal antibodies
Monoclonal antibodies
Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....
recognizing two distinct differentiation antigens Pro-Im1, Pro-Im2 on early hematopoeitic cells. Blood 1984; 64:1169.
49. Rinooy Kan EA, Platzer E, Welte K, and Wang, CY. Modulation induction of the T3 antigen by OKT3 is monocyte dependent. J Immunol 1984; 133:2979.
50. Wang, CY, Azzo W, Al-Katib A, Chiorazzi N and Knowles DM. Preparation and characterization of monoclonal antibodies
Monoclonal antibodies
Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....
recognizing three distinct differentiation antigens (BL1, BL2, and BL3) on human B lymphocytes. J Immunol 1984; 1133:684.
51. Wang, CY, Al-Katib A, Lane CL, Koziner B and Fu, SM. Induction of Leu 10 (HLA-DC/DS) antigen expression by human precurso B cell lines. J Exp Med 1983; 158:1757.
52. Rinooy Kan EA, Wang, CY, Wang LC and Evans RL. Non-covalently bonded subunits of 22KD and 28KD are rapidly internalized by T cells reacted with anti-Leu4 [now termed CD3] antibody. J Immunol 1983; 131:536.
53. Biegler RD, Risher DE, Wang, CY, Rinnooy Kan EA and Kunkel HG. Idiotype-like molecules on cells of a human T-cell leukemia leukemia
Leukemia
Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...
. J Exp Med 1983; 158:1000.
54. Welte K, Platzer EW, Wang, CY, Rinnooy Kan EA, Moore MAS and Mertelsmann R. OKT8 [now termed CD8] antibody inhibits OKT3 [now termed CD3]-induced IL-2 production and proliferation of KT8+ cells. J Immunol 1983; 131:2356.
55. Knowles DM, Tolidgian B, Maiboe CC, Halper J, Azzo W and Wang, CY. A new human B lymphocyte surface antigen (BL2) detected by a monoclonal antibodies
Monoclonal antibodies
Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....
: Distribution of benign and malignant lymphoid cells. Blood 1983; 62:191.
56. Venuta S, Mertelsmann R, Welte K, Feldman S, Wang, CY and Moore MAS. Production and regulation of Interleukin-2 in human lymphoblastic leukemias studied with T cell monoclonal antibodies
Monoclonal antibodies
Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....
. Blood 1983; 61:781.
57. Miki Y, Kishi H, Muragachi A, Maruyama S, Kishimoto S, Yamamura Y, Wang, CY and Kishimoto T. Induction of IgG production in a human monoclonal B lymphoblastoid cell line by a B cell-specific monoclonal antibody (BL2). J Immunol 1982; 1290: 1921.
58. Welte K, Wang, CY, Mertelsmann R, Venuta S, Feldman S and Moore MAS. Purification of human Interleukin-2 to apparent homogeneity and its molecular heterogeneity. J Exp Med 1982; 156:454.
59. Shin HS, Wang, CY and Choi YS. Activation of autologous reactive helpter T lymphocytes for differentiation of human B lymphocytes. J Immunol 1981: 126:2483.
60. Wang, CY, Good RA, Ammirati P, Dymbort G and Evans RL. Identification of a p69/71 complex [now termed LEU 1 or CD5] expressed on human T cells sharing determinants with B type chronic lymphatic leukemia. J Exp Med 1980; 151: 1539.
61. Halper J, Knowles DM and Wang, CY. 1a antigen expression by human malignant lymphomas: correlation with conventional lymphoid markers. Blood 1980; 55:373.
62. Gottlieb AB, FU SM, YU DTY, Wang, CY, Halper JP and Kunkel HG. The nature of the stimulation of cell in human allogeneic and autologous MLC reaction: Role of isolated IgM-bearing B cells. J Immunol 1979; 123: 1497.
63. Wang, CY, Structural and functional characterization of surface antigen on human B lymphocyte
Lymphocyte
A lymphocyte is a type of white blood cell in the vertebrate immune system.Under the microscope, lymphocytes can be divided into large lymphocytes and small lymphocytes. Large granular lymphocytes include natural killer cells...
. Ph.D. Thesis, The Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...
, 1979.
64. Wang, CY, Fu SM and Kunkel HG. Isolation and immunological 65. Fu SM, Chiorazzi N, Wang, CY, Montazeri CM and Kunkel HG> 1a beacharacterization of a major surface glycoprotein (gp54 [now termed CD40] preferentially expressed on certain human B cells. J Exp Med 1979; 149:1434.
65. Fu SM, Chiorazzi N, Wang, CY, Montazeri CM and Kunkel HG> 1a bearing T cells in man. Their identification and role in the generation of allogeneic helper activity. J Exp Med 1978; 148:1423.
66. Winchester RJ, Wang, CY, Gibofsky A, Kunkel HG, Lloyd K and Old, LJ. Expression of 1a-like antigens on cultured human malignant melanoma cell lines. Proc Natl. Acad Sci. 1978; 75:6235.
67. Winchester RJ, Meyers PA, Broxmeyer HE, Wang, CY, Moore MAS and Kunkel HG. Inhibition of human erythropoietic colony formation in culture by treatment with 1a antisera. J Exp Med 1978; 148:613.
68. Halper JP, Fu SM, Wang, CY, Winchester RJ and Kunkel HG. Patterns of expression of human 1a-like antigens during the terminal stages of B cell development. J Immunol 1978; 119:1520.
69. Hoffman T, Wang, CY, Winchester RJ, Ferarrini M and Kunkel HG. Human lymphocyte bearing 1a-like antigens [now termed HLA-DK or class 1 MHC antigen]: Absence in patients with infantile Hypogammaglobulinemia
Hypogammaglobulinemia
Hypogammaglobulinemia is a type of immune disorder characterized by a reduction in all types of gamma globulins.Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.-Terminology:...
. J immunol 1977; 119:1250.
70. Winchester RJ, Ross, GD, Jarowski CI, Wang, CY, Halper J and Broxmeyer HE. Expression of a 1a-like antigen on human granulocytes during early stages of differentiation. Proc Natl Acad Sci 1977; 74:4012.
Professional and honorary affiliations
- National Health Institute, United States National Institutes of HealthNational Institutes of HealthThe National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
- National Taiwan UniversityNational Taiwan UniversityNational Taiwan University is a national co-educational university located in Taipei, Republic of China . In Taiwan, it is colloquially known as "Táidà" . Its main campus is set upon 1,086,167 square meters in Taipei's Da'an District. In addition, the university has 6 other campuses in Taiwan,...
(Adjunct Professor) - National Tsing Hua UniversityNational Tsing Hua UniversityNational Tsing Hua University is one of the most prestigious universities in Taiwan. The university has a strong reputation in the studies of science and engineering. Times Higher Education - World University Rankings is107in the world. Engineering and Science are the best in Taiwan...
(Adjunct Professor)
Public speaking
Dr. Chang Yi Wang has been invited to numerous Presentations and Plenary Lectures in recent years including:• Hsin Chu, Taiwan
Taiwan
Taiwan , also known, especially in the past, as Formosa , is the largest island of the same-named island group of East Asia in the western Pacific Ocean and located off the southeastern coast of mainland China. The island forms over 99% of the current territory of the Republic of China following...
- Tsis-Hua University Lecture Series: “From double Helix to efficacious vaccines through rational design” April 10, 2010
• Taipei
Taipei
Taipei City is the capital of the Republic of China and the central city of the largest metropolitan area of Taiwan. Situated at the northern tip of the island, Taipei is located on the Tamsui River, and is about 25 km southwest of Keelung, its port on the Pacific Ocean...
,Taiwan Forum on Vaccine Industry Development in Taiwan , Taiwan Biotech Association: “A Reflection and New Determination: Site Directed Vaccines and Immunotherapeutics” [Plenary Lecture] July 24, 2008
• Vienna, Austria
Austria
Austria , officially the Republic of Austria , is a landlocked country of roughly 8.4 million people in Central Europe. It is bordered by the Czech Republic and Germany to the north, Slovakia and Hungary to the east, Slovenia and Italy to the south, and Switzerland and Liechtenstein to the...
International Atomic Energy Agency (IAEA)/Food and Agriculture Organization (FAO) and Office of International des Epizooties (OIE) World Organization for Animal Health: Use Of Standards and References for Serological And Molecular Tests for Transboundary Diseases In Livestock Nov. 21-24, 2006
• Montreal
Montreal
Montreal is a city in Canada. It is the largest city in the province of Quebec, the second-largest city in Canada and the seventh largest in North America...
, Canada
Canada
Canada is a North American country consisting of ten provinces and three territories. Located in the northern part of the continent, it extends from the Atlantic Ocean in the east to the Pacific Ocean in the west, and northward into the Arctic Ocean...
5th World Congress on Vaccines, Immunization & Immunotherapy [Plenary Lecture] Nov. 6-9, 2006
• Dubai
Dubai
Dubai is a city and emirate in the United Arab Emirates . The emirate is located south of the Persian Gulf on the Arabian Peninsula and has the largest population with the second-largest land territory by area of all the emirates, after Abu Dhabi...
, UAE 7th Global Vaccinology Forum on Disease Immunization and Immunotherapy: Site-Specific Peptide Vaccines for Immunotherapy and Immunization and for Veterinary Applications [Plenary Lecture] March 5–7, 2005
• Tokyo
Tokyo
, ; officially , is one of the 47 prefectures of Japan. Tokyo is the capital of Japan, the center of the Greater Tokyo Area, and the largest metropolitan area of Japan. It is the seat of the Japanese government and the Imperial Palace, and the home of the Japanese Imperial Family...
, Japan
Japan
Japan is an island nation in East Asia. Located in the Pacific Ocean, it lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south...
4th World Congress on Vaccines & Immunization: Site-Specific PeptideB Vaccines for Immunotherapy and Immunization Against Chronic Diseases, Cancer, Infectious Diseases Infectious Disease
Infectious disease
Infectious diseases, also known as communicable diseases, contagious diseases or transmissible diseases comprise clinically evident illness resulting from the infection, presence and growth of pathogenic biological agents in an individual host organism...
, and for Veterinary Applications [Plenary Lecture], Sept. 30-Oct. 3, 2004
• Washington Washington (state), D.C. US-Taiwan Business Council, The Brookings Institute, and the Center for Strategic and International Studies Symposium on The Taiwan Taiwan
Taiwan
Taiwan , also known, especially in the past, as Formosa , is the largest island of the same-named island group of East Asia in the western Pacific Ocean and located off the southeastern coast of mainland China. The island forms over 99% of the current territory of the Republic of China following...
Presidential Elections: “Political, Economic, & Security Implications” : Reasons to Choose Taiwan May 6, 2004
• Singapore
Singapore
Singapore , officially the Republic of Singapore, is a Southeast Asian city-state off the southern tip of the Malay Peninsula, north of the equator. An island country made up of 63 islands, it is separated from Malaysia by the Straits of Johor to its north and from Indonesia's Riau Islands by the...
Biomedical Asia, Partnering Seminar: UBI as a Rising Star of the Biopharmaceutical Industry Nov. 4, 2003
• San Diego, California
California
California is a state located on the West Coast of the United States. It is by far the most populous U.S. state, and the third-largest by land area...
. Days of Molecular Medicine Symposium: Immunotherapy of Infectious, Chronic Diseases and Cancer by Site-Specific Peptide Vaccines
March 13–15, 2003
• Cambridge
Cambridge
The city of Cambridge is a university town and the administrative centre of the county of Cambridgeshire, England. It lies in East Anglia about north of London. Cambridge is at the heart of the high-technology centre known as Silicon Fen – a play on Silicon Valley and the fens surrounding the...
, Massachusetts
Massachusetts
The Commonwealth of Massachusetts is a state in the New England region of the northeastern United States of America. It is bordered by Rhode Island and Connecticut to the south, New York to the west, and Vermont and New Hampshire to the north; at its east lies the Atlantic Ocean. As of the 2010...
. Knowledge Foundation’s International Conference on HIV Vaccines: Synthetic AIDS Vaccine by Targeting HIV Receptor June 22–23, 2003
• Tainan
Tainan
Tainan City is a city in southern Taiwan. It is the fifth largest after New Taipei, Kaohsiung, Taichung, and Taipei. It was formerly a provincial city, and in 2010, the provincial city merged with the adjacent Tainan County to form a single special municipality. Tainan faces the Taiwan Strait in...
, Taiwan
Taiwan
Taiwan , also known, especially in the past, as Formosa , is the largest island of the same-named island group of East Asia in the western Pacific Ocean and located off the southeastern coast of mainland China. The island forms over 99% of the current territory of the Republic of China following...
International Symposium on Agricultural Biotechnology, National Cheng Kung University National Cheng Kung University
National Cheng Kung University
National Cheng Kung University is a national university in Tainan City, Taiwan. Its abbreviation is NCKU. In Chinese, its name is shortened to 成大...
: Site Specific Synthetic Peptide Antigens and Functional Antigenics: Applications to Animal Health Dec. 13-14, 2002
• Lyon
Lyon
Lyon , is a city in east-central France in the Rhône-Alpes region, situated between Paris and Marseille. Lyon is located at from Paris, from Marseille, from Geneva, from Turin, and from Barcelona. The residents of the city are called Lyonnais....
, France
France
The French Republic , The French Republic , The French Republic , (commonly known as France , is a unitary semi-presidential republic in Western Europe with several overseas territories and islands located on other continents and in the Indian, Pacific, and Atlantic oceans. Metropolitan France...
Foundation Merieux of International Association of Biologicals Standardization: Immunological Application of Synthetic Peptides May 9–11, 2001
• Amsterdam
Amsterdam
Amsterdam is the largest city and the capital of the Netherlands. The current position of Amsterdam as capital city of the Kingdom of the Netherlands is governed by the constitution of August 24, 1815 and its successors. Amsterdam has a population of 783,364 within city limits, an urban population...
, Netherlands
Netherlands
The Netherlands is a constituent country of the Kingdom of the Netherlands, located mainly in North-West Europe and with several islands in the Caribbean. Mainland Netherlands borders the North Sea to the north and west, Belgium to the south, and Germany to the east, and shares maritime borders...
IAVI Neutralization Task Force: Immunoprophylaxis, Immunotherapy, and a Synthetic AIDS
AIDS
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the human immunodeficiency virus...
Vaccine Targeting HIV Hiv
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
Receptors April 25, 2001
• London
London
London is the capital city of :England and the :United Kingdom, the largest metropolitan area in the United Kingdom, and the largest urban zone in the European Union by most measures. Located on the River Thames, London has been a major settlement for two millennia, its history going back to its...
, England
England
England is a country that is part of the United Kingdom. It shares land borders with Scotland to the north and Wales to the west; the Irish Sea is to the north west, the Celtic Sea to the south west, with the North Sea to the east and the English Channel to the south separating it from continental...
HIV Therapeutics: Searching for the Next Generation: Immunoprophylaxis, Immunotherapy, and a Synthetic AIDS Aids
AIDS
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the human immunodeficiency virus...
Vaccine Targeting HIV Receptors Feb. 28-Mar 1, 2001
• Baltimore
Baltimore
Baltimore is the largest independent city in the United States and the largest city and cultural center of the US state of Maryland. The city is located in central Maryland along the tidal portion of the Patapsco River, an arm of the Chesapeake Bay. Baltimore is sometimes referred to as Baltimore...
, Maryland
Maryland
Maryland is a U.S. state located in the Mid Atlantic region of the United States, bordering Virginia, West Virginia, and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware to its east...
Meeting of the Institute of Human Virology: Postexposure Immunoprophylaxis of Primary Isolate by an Antibody to HIV Receptor Complex Sept. 15, 2000
External links
- Official site
- UBI Asia official site
- UBI-Asia on The Free Library, United Biomedical, Inc. and Development Fund, Executive Yuan of the Republic of China Establish UBI-Asia as a Biopharmaceutical Joint Venture.