DS-1 (drug)
Encyclopedia
DS-1 is a drug from the imidazopyridine
family which is the first drug developed that acts as a GABAA receptor
agonist
selective for the α4
β3
δ
subtype, which is not targeted by other GABA agonists such as the benzodiazepine
s or other nonbenzodiazepine
drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.
Imidazopyridine
The imidazopyridines are a class of drugs defined by their chemical structure. They are generally GABAA receptor agonists, however recently proton pump inhibitors in this class have been developed as well. Despite usually being similar to them in effect, they are not chemically related to...
family which is the first drug developed that acts as a GABAA receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
selective for the α4
GABRA4
Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene....
β3
GABRB3
Gamma-aminobutyric acid receptor subunit beta-3 is a protein that in humans is encoded by the GABRB3 gene....
δ
GABRD
Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene....
subtype, which is not targeted by other GABA agonists such as the benzodiazepine
Benzodiazepine
A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...
s or other nonbenzodiazepine
Nonbenzodiazepine
The nonbenzodiazepines, also called benzodiazepine-like drugs, are a class of psychoactive drugs pharmacologically resembling the benzodiazepines, with similar benefits, side effects and risks, despite having dissimilar or entirely different chemical structures.-Classes:There are currently three...
drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.